[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"women\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:women":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,25,0,[8,43,70,107,133,157,181,208,233,254,296,325,354,380,413,445,479,502,521,549,576,605,633,655,681],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100644665","early-phase-1-beta3-adrenergic-receptors-and-cardiovascular-function-in-aging-women-100644665",false,"NCT07674680","Beta3-adrenergic Receptors and Cardiovascular Function in Aging Women","Inclusion Criteria:\n\nHealthy women Assigned female at birth 18-70 years of age Body mass index \\\u003C18 or ≥30 kg\u002Fm2\n\nExclusion Criteria:\n\nAssigned male at birth Pregnancy Breastfeeding History of hormone replacement therapy, chemical menopause, or oophor-ectomy Polycystic ovarian syndrome or Primary ovarian insufficiency Current smoking\u002FNicotine use Blood pressure ≥140\u002F90 mmHg Increased risk of bleeding, pro-coagulant disorders, clotting disorders, anticoagulation therapy Nerve\u002Fneurologic disease Cardiovascular, hepatic, renal, respiratory disease Hypersensitivity to nitroglycerin Diabetes Communication barriers",true,"FEMALE","18 Years","70 Years",{"count":20,"type":21},60,"ESTIMATED","INTERVENTIONAL",[24],"EARLY_PHASE1","We hypothesize vascular beta3 adrenergic receptors are present and functional in aging women and can be targeted to attenuate sympathetic vasoconstriction and enhance vascular function in aging women.",[27,28,29],"Women","Aging","Menopause","NOT_YET_RECRUITING","2026-06-23",{"date":33,"type":34},"2026-06-29","ACTUAL",{"date":36,"type":21},"2026-07",{"date":38,"type":21},"2029-05",{"name":40,"class":41},"University of Missouri-Columbia","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":47,"acronym":48,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":50,"targetDuration":4,"studyType":22,"phases":51,"briefSummary":53,"conditions":54,"keywords":58,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":42},"100642067","the-effect-of-virtual-reality-based-intervention-on-anxiety-stress-and-pain-in-women-undergoing-colposcopy-a-randomized-controlled-trial-100642067","NCT07650422","The Effect of Virtual Reality-Based Intervention on Anxiety, Stress, and Pain in Women Undergoing Colposcopy: A Randomized Controlled Trial","Colposcopy","Inclusion Criteria:\n\nBe 18 years of age or older, Have colposcopy scheduled due to a cervical cytology result of LSIL, HSIL, ASC-US, or HPV positivity, Be able to read and understand Turkish, Provide voluntary written informed consent -\n\nExclusion Criteria:\n\nDiagnosis of a mental disorder Severe visual impairment, claustrophobia, cognitive impairment History of severe motion sickness (cybersickness) associated with virtual reality use Use of anxiolytic\u002Fanalgesic medication prior to the procedure Individuals with severe cognitive impairment or communication difficulties\n\n\\-",{"count":20,"type":21},[52],"NA","Due to its invasive nature, the colposcopy procedure can cause high levels of anxiety, stress, pain, and nausea in women. The uncertainty surrounding the condition to be diagnosed, combined with the discomfort caused by the procedure itself, creates significant psychological stress in women and can negatively impact their compliance with diagnosis and treatment. Therefore, it is believed that applying Virtual Reality (VR) technology-one of the distraction techniques-as a non-pharmacological method for women undergoing colposcopy could be effective in reducing pain and anxiety by diverting their cognitive attention away from the procedure's negative stimuli. Although there are many studies in the literature using VR technology, no study has been found that examines the effect of VR-based interventions on anxiety, stress, and pain levels in women undergoing colposcopy. Therefore, this study will be one of the first randomized controlled trials to examine the multidimensional effects of virtual reality (anxiety, stress, pain) in women undergoing colposcopy. The findings will contribute to the widespread adoption of non-pharmacological nursing interventions in clinical practice. The aim of this study is to comprehensively evaluate the effect of a virtual reality (VR)-based intervention on anxiety, stress, and pain levels in women undergoing colposcopy and to determine its efficacy compared to standard care.",[55,56,57,48,27],"Virtual Reality-Based Intervention","Anxiety","Stress",[27,48,55,56,57,59],"Pain","RECRUITING","2026-06-10",{"date":63,"type":34},"2026-06-16",{"date":65,"type":34},"2026-02-01",{"date":67,"type":21},"2026-10-01",{"name":69,"class":41},"Osmaniye Korkut Ata University",{"id":71,"slug":72,"hasResults":11,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":4,"eligibilityCriteria":76,"healthyVolunteers":15,"sex":77,"minAge":17,"maxAge":4,"enrollmentInfo":78,"targetDuration":4,"studyType":80,"phases":4,"briefSummary":81,"conditions":82,"keywords":86,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":42},"100635380","womens-reproductive-choices-and-mental-health-during-pregnancy-and-after-birth-in-wartime-ukraine-100635380","NCT07551934","Women's Reproductive Choices and Mental Health During Pregnancy and After Birth in Wartime Ukraine","Integrative Model of Factors Influencing Reproductive Behavior and Perinatal Mental Health of Women Amidst War","Inclusion Criteria:\n\n* able and willing to provide informed consent;\n* aged 18 years or older.\n\nExclusion Criteria:\n\n* younger than 18 years;\n* unable to provide informed consent;\n* do not have sufficient language proficiency to complete the study procedures;\n* at the time of recruitment, they have an acute medical or psychological condition that would make participation unsafe, inappropriate, or unduly burdensome (e.g., obstetric emergencies, immediate postoperative or critical care status, or severe acute distress requiring urgent clinical care);\n* participation or the handling of personal data could reasonably pose a risk to the safety of the participant or their family.","ALL",{"count":79,"type":21},328,"OBSERVATIONAL","The goal of this observational study is to learn how war affects reproductive decisions and perinatal mental health in Ukrainian women.\n\nThe main questions it aims to answer are: (1) how are wartime stress and trauma related to women's decisions about pregnancy and childbirth?; (2) what mental health symptoms and psychological difficulties are experienced during the perinatal period under wartime conditions? (3) which demographic, obstetric, and psychological factors are linked to poorer mental health and childbirth experiences?\n\nResearchers will survey at least 300 women.\n\nParticipants will: (1) complete questionnaires about their mental health and psychological well-being; (2) answer questions about their reproductive choices, pregnancy, and\u002For childbirth experiences; (3) report on the impact of war, social support, maternal care, and postpartum trauma; (4) provide demographic and obstetric information.\n\nThe findings will be used to develop an evidence-based model of the factors influencing reproductive behavior and perinatal mental health during war.",[83,84,27,85],"Perinatal Mental Health","Reproductive Behavior","Cohort Studies",[87,88,89,90,91,92,93,94,95,96,97],"perinatal psychology","mental health","reproductive behavior","psychological trauma","PTSD","CB-PTSD","postpartum depression","pregnancy","sexual health","Ukraine","war-affected population","2026-05-04",{"date":100,"type":34},"2026-05-08",{"date":102,"type":21},"2026-06",{"date":104,"type":21},"2028-11",{"name":106,"class":41},"Taras Shevchenko National University of Kyiv",{"id":108,"slug":109,"hasResults":11,"nctId":110,"briefTitle":111,"officialTitle":112,"acronym":4,"eligibilityCriteria":113,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":114,"enrollmentInfo":115,"targetDuration":4,"studyType":22,"phases":117,"briefSummary":118,"conditions":119,"keywords":120,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":124,"lastUpdatePostDateStruct":125,"startDateStruct":127,"completionDateStruct":129,"leadSponsor":131,"locationsCount":4},"100558644","genital-self-mage-and-satisfaction-with-genital-appearance-100558644","NCT06553807","Genital Self İmage and Satisfaction With Genital Appearance","The Effect of Education Given to Women With Low Genital Self Image on Satisfaction With Genital Appearance and Quality of Sexual Life","Inclusion Criteria:\n\n* 18-49 years old,\n* Sexually active for at least 1 year,\n* Not having language and communication problems,\n* Literate.\n\nExclusion Criteria:\n\n* Pregnancy within the last year,\n* She had a previous gynaecological operation,\n* Experiencing early menopause,\n* Diagnosed with gynaecological cancer or undergoing cancer treatment,","49 Years",{"count":116,"type":21},80,[52],"The concept of genital self-image first emerged alongside genital identity. Womens perceptions of their genital self encompass their feelings and subjective thoughts about their sexual organs. One of the most significant problems resulting from a negative genital self-image is sexual health. It has been reported that genital self-perception and self-image are related to sexual health. Another study that examined the effects of viewing various vulvar photographs on womens genital attitudes found that women had relatively positive genital self-images before viewing the photographs, but their perceptions became even more positive after viewing them. This study aims to examine the impact of education on genital appearance satisfaction and sexual quality of life in women with low genital self-image. It is hypothesized that women with low genital self-image who receive education will have more knowledge about genital anatomy, which will positively influence their genital appearance, genital self-image, and consequently improve their sexual quality of life.\n\nThe study is a randomized controlled experimental research. The research will be conducted women aged 18-49 years with low genital self-image who are registered at a Family Health Center (FHC). Data collection tools in the study will include a socio-demographic data form prepared by the researchers, the Genital Self-Image Scale, the Genital Appearance Satisfaction Scale, and the Sexual Quality of Life Scale. The SPSS 24.0 software package is planned to be used for data analysis. Descriptive statistics such as mean, standard deviation, number, and percentage will be used in the analysis of the quantitative data. The normality of the data distribution will be assessed, and parametric or non-parametric tests will be applied based on the distribution. Additionally, regression analyses will be used to evaluate the effect, and a significance level of 0.05 will be accepted for the entire study.",[27],[121,122,27,123],"Genital self-image","Satisfaction with genital appearance","Quality of sexual life","2026-03-23",{"date":126,"type":34},"2026-03-27",{"date":128,"type":21},"2026-05-30",{"date":130,"type":21},"2026-10-20",{"name":132,"class":41},"Inonu University",{"id":134,"slug":135,"hasResults":11,"nctId":136,"briefTitle":137,"officialTitle":138,"acronym":139,"eligibilityCriteria":140,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":141,"targetDuration":4,"studyType":22,"phases":143,"briefSummary":144,"conditions":145,"keywords":4,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":149,"lastUpdatePostDateStruct":150,"startDateStruct":151,"completionDateStruct":153,"leadSponsor":155,"locationsCount":42},"100570116","a-multi-level-trauma-informed-approach-to-increase-hiv-pre-exposure-prophylaxis-initiation-among-black-women-100570116","NCT06703060","A Multi-Level Trauma-Informed Approach to Increase HIV Pre-exposure Prophylaxis Initiation Among Black Women","Trauma-Informed HIV Prevention for Black Women in Baltimore","MATCH","Inclusion Criteria:\n\n* self-identified Black cisgender woman;\n* self-reported HIV-negative status, and\n* ≥18 years.\n* reports unprotected vaginal or anal sex in the past 6 months with a male sexual partner,\n* have at least one substantial HIV risk factor in the past 6 months according to the 2021 Centers for Disease Control (CDC) PrEP Eligibility Guidelines (i.e., HIV-positive sexual partner, recent bacterial Sexually Transmitted Disease (STD), 2+ sex partners, history of inconsistent or no condom use, commercial sex work, and residing in high HIV prevalence area or network), and\n* never taken PrEP\n\nExclusion Criteria:\n\n* non-English speaking and\n* currently living with HIV",{"count":142,"type":21},300,[52],"U.S. epidemiological data indicates that Black women are a high-risk HIV disparity group, yet initiation of novel prevention strategies like pre-exposure prophylaxis (PrEP) among this group is stagnant. Socio-structural challenges like intimate partner violence and gendered racism can constrain PrEP access among Black women, but few implementation studies have mitigated these challenges to improve PrEP initiation. The proposed research aims to implement and assess the effectiveness, implementation, and sustainability of a multilevel intervention to increase PrEP initiation among Black women with and without intimate partner violence in Baltimore.",[146,147,27,148],"HIV Prevention","PrEP","Intimate Partner Violence (IPV)","2026-03-19",{"date":124,"type":34},{"date":152,"type":34},"2025-02-28",{"date":154,"type":21},"2028-02",{"name":156,"class":41},"Johns Hopkins Bloomberg School of Public Health",{"id":158,"slug":159,"hasResults":11,"nctId":160,"briefTitle":161,"officialTitle":162,"acronym":4,"eligibilityCriteria":163,"healthyVolunteers":11,"sex":16,"minAge":164,"maxAge":165,"enrollmentInfo":166,"targetDuration":4,"studyType":22,"phases":168,"briefSummary":169,"conditions":170,"keywords":4,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":173,"lastUpdatePostDateStruct":174,"startDateStruct":176,"completionDateStruct":177,"leadSponsor":179,"locationsCount":42},"100620081","transcutaneous-tibial-nerve-stimulation-on-women-with-primary-dysmenorrhea-100620081","NCT07352982","Transcutaneous Tibial Nerve Stimulation on Women With Primary Dysmenorrhea","Effect of Transcutaneous Tibial Nerve Stimulation on Women With Primary Dysmenorrhea","Inclusion Criteria:\n\n* Age ranges from 20-25 years old.\n* Body mass index (BMI) doesn't exceed 30 kg\u002Fm2.\n* Patients referred from a Gynecologist with a diagnosis of Primary Dysmenorrhea (PD).\n* Patients have regular menstrual cycles.\n* Patients suffer from pain located in the suprapubic area, abdomen, lower lumbar area, perineum, and\u002For medial aspect of the thighs during at least half of their annual menstrual cycles and\u002For in the last 3 cycles.\n\nExclusion Criteria:\n\n* Patients diagnosed with gynecological pathology.\n* Patients taking oral contraceptives or had an intrauterine device implanted.\n* Patients had bad obstetric situations or diseases that could interfere with participation.\n* Patients have certain disorders including uncorrected coagulopathies, severe comorbid disorder, cancer in the last 5 years or at present, presence of erosions on the inner aspect of the ankle, severe mental disorders, or neuropathies affecting the lower limb.\n* Patients who are smoking or taking oral sedatives.\n* Patients had undergone surgery or childbirth in the last 6 months.\n* Patients who are pregnant.","20 Years","25 Years",{"count":167,"type":21},32,[52],"This study aims to investigate the effects of transcutaneous tibial nerve stimulation (TTNS) on women with primary dysmenorrhea (PD).",[171,27,172],"Transcutaneous Tibial Nerve Stimulation","Primary Dysmenorrhea","2026-01-19",{"date":175,"type":34},"2026-01-21",{"date":173,"type":34},{"date":178,"type":21},"2026-07-01",{"name":180,"class":41},"Kafrelsheikh University",{"id":182,"slug":183,"hasResults":11,"nctId":184,"briefTitle":185,"officialTitle":186,"acronym":187,"eligibilityCriteria":188,"healthyVolunteers":11,"sex":77,"minAge":17,"maxAge":4,"enrollmentInfo":189,"targetDuration":4,"studyType":80,"phases":4,"briefSummary":190,"conditions":191,"keywords":194,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":198,"lastUpdatePostDateStruct":199,"startDateStruct":201,"completionDateStruct":203,"leadSponsor":205,"locationsCount":207},"100617338","norwegian-spontaneous-coronary-artery-dissection-study-100617338","NCT07317323","Norwegian Spontaneous Coronary Artery Dissection Study","Norwegian Spontaneous Coronary Artery Dissection Study (NOR-SCAD Study)","NOR-SCAD","Inclusion Criteria:\n\n* Spontaneous coronary artery dissection\n\nExclusion Criteria:\n\n* Severe kidney failure\n* Severe allergic reaction to contrast",{"count":142,"type":21},"The Norwegian Spontaneous Coronary Artery Dissection Study (NOR-SCAD) is a national, multicenter prospective observational study conducted at major hospitals in Norway. The study investigates risk factors and complications of spontaneous coronary artery dissection (SCAD). Patients aged 18 years or older who are hospitalized with SCAD are recruited during the index hospitalization. Each participant will be followed for 52 weeks with scheduled visits at 8 and 12 weeks and a final phone call at 52 weeks. Evaluations include coronary CT angiography (CTA), cardiac assessments, genetic analyses, blood sampling, structured questionnaires, and a cardiopulmonary exercise test (CPET).",[192,193,27],"SCAD","Myocardial Infarction (MI)",[195,187,196,197],"SCAD NORGE","Spontan Koronar arteriedisseksjon studie","Norwegian Spontaneous Coronary artery dissection study","2025-12-18",{"date":200,"type":34},"2026-01-05",{"date":202,"type":34},"2025-04-01",{"date":204,"type":21},"2035-12-31",{"name":206,"class":41},"Oslo University Hospital",3,{"id":209,"slug":210,"hasResults":11,"nctId":211,"briefTitle":212,"officialTitle":212,"acronym":213,"eligibilityCriteria":214,"healthyVolunteers":15,"sex":16,"minAge":215,"maxAge":164,"enrollmentInfo":216,"targetDuration":4,"studyType":22,"phases":218,"briefSummary":219,"conditions":220,"keywords":221,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":224,"lastUpdatePostDateStruct":225,"startDateStruct":227,"completionDateStruct":229,"leadSponsor":231,"locationsCount":42},"100614010","effect-of-manual-lymphatic-drainage-on-muscle-fatigue-in-female-11-a-side-football-players-100614010","NCT07274033","Effect of Manual Lymphatic Drainage on Muscle Fatigue in Female 11-a-side Football Players","EDLMF11","Inclusion Criteria:\n\n* Female athletes actively participating in 11-a-side football, either federated or official team members.\n* Age ≥ 16 years to 20 years old.\n* Regular training (≥ 3 sessions per week) or active competition\n* No food intake within 3 hours prior to evaluation (to standardize the influence of digestion on performance).\n* No acute lower limb injury in the past 3 months.\n* Availability to attend all three study visits.\n* Signed informed consent; for participants under 18, parental consent is also required.\n\nExclusion Criteria:\n\n* History of deep vein thrombosis\n* Decompensated heart failure\n* Active lower limb infection\n* Pregnancy\n* Recent lower limb surgery (\\\u003C 3 months), or any medical contraindication to receiving manual lymphatic drainage (MLD).\n* Failure to comply with the fasting requirement prior to performance testing.","16 Years",{"count":217,"type":21},11,[52],"This clinical trial investigates the effectiveness of manual lymphatic drainage (MLD) in accelerating recovery following induced fatigue in female football players. The study integrates objective performance measurements using linear encoders with anthropometric assessments and psychophysiological evaluations. It aims to quantify the impact of MLD on neuromuscular recovery, muscle edema, and perceived fatigue, considering sex-specific physiological factors and the influence of sleep and psychological stress. The findings will contribute to developing non-invasive, individualized recovery strategies to enhance performance and reduce injury risk in women's football.",[27],[222,223,27],"Manual Lymphatic Drainage","Football","2025-12-09",{"date":226,"type":34},"2025-12-10",{"date":228,"type":34},"2025-11-17",{"date":230,"type":21},"2026-07-30",{"name":232,"class":41},"Camilo Jose Cela University",{"id":234,"slug":235,"hasResults":11,"nctId":236,"briefTitle":237,"officialTitle":237,"acronym":4,"eligibilityCriteria":238,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":239,"targetDuration":4,"studyType":22,"phases":241,"briefSummary":242,"conditions":243,"keywords":4,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":246,"lastUpdatePostDateStruct":247,"startDateStruct":249,"completionDateStruct":251,"leadSponsor":253,"locationsCount":42},"100556122","early-phase-1-early-neurovascular-adaptations-in-aging-women-100556122","NCT06520982","Early Neurovascular Adaptations in Aging Women","Inclusion Criteria:\n\n* Assigned female at birth (AFAB)\n* 18-70 years of age\n\nExclusion Criteria:\n\n* Assigned male at birth (AMAB)\n* Pregnancy, breastfeeding\n* Body mass index ≥30 kg\u002Fm2\n* Taking medications known to affect metabolic, autonomic, and\u002For respiratory function\n* Oral hormonal contraception in last 6 month\n* History of hormone replacement therapy\n* History of hyster- or oophor-ectomy\n* Current smoking\u002FNicotine use\n* Increased risk of bleeding, pro-coagulant disorders, clotting disorders, anticoagulation therapy\n* Chronic disease\n* Blood pressure ≥140\u002F90 mmHg\n* Communication barriers",{"count":240,"type":21},64,[24],"Our goal is to enhance our understanding of early vascular adaptations in aging women with an emphasis on the sympathetic nervous system.",[27,244,28,245],"Sympathetic Nervous System","Blood Flow","2025-11-20",{"date":248,"type":34},"2025-11-26",{"date":250,"type":34},"2024-09-20",{"date":252,"type":21},"2028-06-30",{"name":40,"class":41},{"id":255,"slug":256,"hasResults":11,"nctId":257,"briefTitle":258,"officialTitle":259,"acronym":260,"eligibilityCriteria":261,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":262,"targetDuration":4,"studyType":22,"phases":264,"briefSummary":265,"conditions":266,"keywords":275,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":287,"lastUpdatePostDateStruct":288,"startDateStruct":290,"completionDateStruct":292,"leadSponsor":294,"locationsCount":42},"100610142","postpartum-education-via-artificial-intelligence-for-recovery-and-loneliness-a-randomized-controlled-trial-100610142","NCT07223736","Postpartum Education Via Artificial Intelligence for Recovery and Loneliness: A Randomized Controlled Trial","Postpartum Education Via Artificial Intelligence for Recovery and Loneliness (PEARL): A Randomized Controlled Trial","PEARL","Inclusion Criteria:\n\n1. Has the capacity to provide informed consent\n2. Stated willingness to comply with all study procedures and availability for the duration of the study\n3. Postpartum persons, aged \\>18 years old\n4. Primiparous\n5. Vaginal or cesarean delivery\n6. English Speaking\n7. Internet access and proficiency of internet access\n8. Access to a smartphone\n9. Postpartum 2-6 weeks\n\nExclusion Criteria:\n\n1. Multiparous\n2. Major neonatal anomaly\n3. Delivery \\\u003C 34 weeks gestational age\n4. Intrauterine fetal demise (IUFD)\n5. Enrollment in any interfering studies\n6. Unanticipated NICU admission\n7. Discharge home without live baby\n8. Surrogates\u002Fgestational carrier\n9. Birthing individuals with baby placed for adoption\n10. Currently pregnant\n11. Psychiatric history requiring psychiatric hospitalization prior to delivery\n12. Other psychiatric conditions needing immediate attention and intervention as determined by study team and\u002For treatment team",{"count":263,"type":21},130,[52],"The goal of this clinical trial is to learn whether a postpartum chatbot powered by generative artificial intelligence (genAI) can help new mothers get better pelvic floor health information and feel less lonely after childbirth.\n\nThe main questions this study aims to answer are:\n\n* Does using the chatbot improve postpartum pelvic floor health knowledge?\n* Does using the chatbot help reduce feelings of loneliness during the postpartum period?\n* Does using the chatbot impact pelvic floor symptoms?\n\nResearchers will compare standard postpartum care to standard care plus the chatbot.\n\nParticipants will:\n\nBe assigned by chance (like flipping a coin) to standard postpartum care with or without access to the chatbot.\n\nIf in the chatbot group, participants will receive education and support via the chatbot over a 4-week period.\n\nBoth groups will complete questionnaires to measure their pelvic floor knowledge, pelvic floor symptoms, feelings of loneliness, depression, infant bonding, perceived social support, adverse childhood experiences, and peri-traumatic distress.\n\nThe chatbot was created by urogynecology experts in collaboration with UC San Diego computer science and biomedical informatics researchers. The chatbot is designed to give new mothers personalized, evidence-based information and support in real time.",[267,268,269,270,271,272,27,273,274],"Pelvic Floor Disorder","Loneliness","Postpartum","Mental Health","Depression","Peritraumatic Distress","Artificial Intelligence (AI)","Chatbot",[276,277,278,88,279,280,281,282,283,284,285,286],"loneliness","postpartum","pelvic floor disorder","depression","peritraumatic distress","artificial intelligence","AI","chatbot","LLM","women","large language model","2025-10-31",{"date":289,"type":34},"2025-11-03",{"date":291,"type":21},"2025-11-10",{"date":293,"type":21},"2026-11-01",{"name":295,"class":41},"University of California, San Diego",{"id":297,"slug":298,"hasResults":11,"nctId":299,"briefTitle":300,"officialTitle":300,"acronym":301,"eligibilityCriteria":302,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":303,"enrollmentInfo":304,"targetDuration":4,"studyType":22,"phases":306,"briefSummary":307,"conditions":308,"keywords":311,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":316,"lastUpdatePostDateStruct":317,"startDateStruct":319,"completionDateStruct":321,"leadSponsor":323,"locationsCount":42},"100554889","evaluation-of-anterior-tibial-knee-translation-in-healthy-women-with-and-without-hormone-therapy-100554889","NCT06504953","Evaluation of Anterior Tibial Knee Translation in Healthy Women With and Without Hormone Therapy","LAX","Inclusion Criteria:\n\n* Female between 18 and 40 years of age;\n* No history of surgery on the 2 lower limbs;\n* No change in contraceptive method in the last 6 months;\n* Signature of informed consent ;\n* Social security affiliation;\n* D14 of her menstrual cycle (+\u002F-1 day) (the first day of the cycle (D1) being considered as the first day of menstruation), except for those on unregulated micro-progestogen contraception.\n\nExclusion Criteria:\n\n* Pregnancy or breastfeeding (check with urine pregnancy test);\n* Menopause;\n* Surgery: tubal ligation, oophorectomy, adnexectomy, hysterectomy;\n* History of inflammatory joint disease, systemic or localized to the knee;\n* History of microcrystalline or infectious pathology localized to the knee;\n* History of fracture, severe sprain or dislocation of the knee joint;\n* History of osteoarticular or congenital diseases that may lead to ACL laxity (e.g. Marfan syndrome, trisomy 21, Ehlers-Danlos syndrome, etc.);\n* Signs of hyperlaxity (Beighton test \\> 4);\n* BMI \\> 25 ;\n* Daily alcohol consumption above the thresholds recommended by Public Health in France (more than 2 glasses per day);\n* Intense or unusual physical exercise during the last 72 hours before the inclusion visit;\n* Inability to understand the protocol;\n* Women under guardianship, curatorship or deprived of liberty.","40 Years",{"count":305,"type":21},90,[52],"Women are recognized as being at greater risk of ACL injury, with a risk 6 times higher than that of men. Hyperlaxity is a risk factor for ACL injury, but the pathophysiological basis for this is poorly studied. Hormonal impregnation and certain periods of the menstrual cycle (ovulatory phase) are risk factors for ACL injury. It therefore seems interesting to study the influence of hormonal impregnation on ligament laxity. To date, to our knowledge, no study has investigated such a relationship.",[27,309,310],"Tibial Translation","Hormone",[312,313,314,315],"hormonale","anterior tibial translation","knee","anterior cruciate ligament","2025-10-01",{"date":318,"type":34},"2025-10-02",{"date":320,"type":34},"2024-08-01",{"date":322,"type":21},"2026-08",{"name":324,"class":41},"Centre Hospitalier Universitaire de Nice",{"id":326,"slug":327,"hasResults":11,"nctId":328,"briefTitle":329,"officialTitle":330,"acronym":4,"eligibilityCriteria":331,"healthyVolunteers":15,"sex":16,"minAge":332,"maxAge":333,"enrollmentInfo":334,"targetDuration":4,"studyType":22,"phases":336,"briefSummary":338,"conditions":339,"keywords":342,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":345,"lastUpdatePostDateStruct":346,"startDateStruct":348,"completionDateStruct":350,"leadSponsor":352,"locationsCount":42},"100525941","phase-2-acute-equol-supplementation-and-vascular-function-in-women-with-and-without-ckd-100525941","NCT06128278","Acute Equol Supplementation and Vascular Function in Women With and Without CKD","Acute Equol Supplementation and Vascular Function in Postmenopausal Women With and Without CKD","Inclusion Criteria:\n\n1. Postmenopausal (50-69 y) women\n2. Women with CKD including stage 3-4 (eGFR 15-59 ml\u002Fmin\u002F1.73m2) determined by the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) 2021 equation\n3. Women without CKD (eGFR \\>60 ml\u002Fmin\u002F1.73m2) must be healthy (free from hypertension, kidney disease, CVD, diabetes, and other chronic disease as assessed by self-report, medical history, and screening labs).\n\nExclusion Criteria:\n\n1. Use of HRT or has used HRT for \\\u003C6 months prior to enrollment\n2. Advanced CKD requiring dialysis\n3. History of kidney transplant\n4. Use of immunosuppressant medications (unless taking a stable dosage for a quiescent disease)\n5. Current tobacco or nicotine use or history of use in the last 12 months\n6. Antioxidant and\u002For omega-3 fatty acid use within the 2 weeks prior to testing\n7. Marijuana use within 2 weeks prior to testing\n8. Consumption of soy and soy-based products 3 days prior to testing\n9. Uncontrolled hypertension in CKD group (BP\\>140\u002F90 mmHg)\n10. Atrial fibrillation\n11. Active infection or antibiotic therapy\n12. Hospitalization in the last month","50 Years","69 Years",{"count":335,"type":21},38,[337],"PHASE2","The risk of cardiovascular disease (CVD) is significantly elevated in patients with chronic kidney disease (CKD). Notably, women with CKD commonly experience menstrual disturbances induced by CKD, which may contribute to impaired vascular function and elevated CVD risk. However, most of the literature in nephrology focuses on male patients, and studies on women's vascular health are limited. Establishing effective therapies for improving vascular function and reducing CVD risk in women with CKD is a high research priority of the NIH.\n\nEquol contributes to improvement in vascular function, mediated in part by its anti-oxidative and anti-inflammatory properties. However, there is no information on the effect of equol on vascular function in women with CKD. The proposed project aims to determine the acute effect (1-hour, 2-hours, and 3-hours post ingestion) of oral equol supplementation on vascular function in postmenopausal women with and without CKD.",[340,341,27],"Chronic Kidney Diseases","Vascular Function",[343,344,341,27],"S-equol","Chronic Kidney Disease","2025-09-23",{"date":347,"type":34},"2025-09-30",{"date":349,"type":34},"2023-03-07",{"date":351,"type":21},"2026-12-31",{"name":353,"class":41},"University of Colorado, Denver",{"id":355,"slug":356,"hasResults":11,"nctId":357,"briefTitle":358,"officialTitle":359,"acronym":360,"eligibilityCriteria":361,"healthyVolunteers":11,"sex":16,"minAge":303,"maxAge":4,"enrollmentInfo":362,"targetDuration":4,"studyType":22,"phases":364,"briefSummary":365,"conditions":366,"keywords":367,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":371,"lastUpdatePostDateStruct":372,"startDateStruct":374,"completionDateStruct":376,"leadSponsor":378,"locationsCount":42},"100603120","feasibility-of-different-types-of-exercise-training-in-perimenopausal-females-100603120","NCT07132385","Feasibility of Different Types of Exercise Training in Perimenopausal Females","Perimenopause: Window for Exercise and Resilience Pilot Study","POWER","Inclusion Criteria:\n\n* Biological females in early and late perimenopause. Menopausal stage will be defined according to the Stages of Reproductive Aging Workshop +10 (STRAW+10). According to STRAW+10, perimenopause is characterized by menstrual cycle irregularity, specifically defined as having bleeding in the previous 12 months but at least a 7-day difference from usual menstrual cycle length\n* Experiencing menopause symptoms (e.g., hot flashes, night sweats, joint stiffness)\n* Aged 40 years or older\n* Multiple risk factors for cardiometabolic disease, namely being sedentary (\\\u003C30 min of moderate-vigorous physical activity\u002Fweek), having a BMI ≥25 kg\u002Fm2, and a waist circumference indicative of abdominal obesity, specific to BMI (e.g., BMI 25-29.9: WC: 90cm; BMI 30-34.9: WC: 105cm; BMI 35-35.9: WC:115cm).\n\nExclusion Criteria:\n\n* History of reproductive surgeries including oophorectomy, hysterectomy, ablation or gender-affirming.\n* Diagnosis of cardiovascular disease, type 2 diabetes, non-alcoholic fatty liver disease, cancer (except for non-melanoma skin cancer), respiratory disease (e.g., Chronic Obstructive Pulmonary Disease or severe or uncontrolled asthma), uncontrolled hyper- or hypogonadism (change in medication or dosage in last 6 months and with major symptoms), and\u002For Polycystic Ovary Syndrome\n* Major signs or symptoms (regardless of known diagnosis) of cardiovascular diseases, diabetes, or renal disease\n* The use of medication that could impact blood glucose\n* Pregnant or post-partum \\\u003C12 months, lactating or breast feeding within 3 months of the start of study\n* Recreational smoking (e.g., tobacco, smoking)\n* Actively engaging in a low-carbohydrate diet (e.g., ketogenic, Atkins)\n* Using transdermal hormones, taking exogenous hormones, or receiving exogenous hormones from other means (e.g., intrauterine device)\n* Significant weight loss (i.e., \\>5 kg) in past 3 months or currently taking weight loss medications",{"count":363,"type":21},30,[52],"Throughout the menopause transition, women experience many symptoms (i.e., hot flashes, night sweats) that can significantly reduce their quality of life. Moreover, their risk of heart disease increases substantially. The years before menopause called \"perimenopause\" present a critical window of intervention to alleviate menopause symptoms and improve health outcomes. Our team is therefore interested in comparing the potential benefits of different approaches including following the Health Canada guidelines (i.e., accumulating 150 min of moderate-to-vigorous aerobic physical activity weekly); performing high-intensity interval training (HIIT), which involves alternating periods of intense exercise with periods of rest; or stretching in perimenopause. As a first step towards this goal, this study will assess how easy and enjoyable the interventions are to follow over a 6-week period. The information gained from this study will be used to perform a larger study with enough participants to assess the health and quality of life impacts of adopting these different strategies in perimenopause.",[27],[368,369,370],"menopause","perimenopause","exercise","2025-09-02",{"date":373,"type":34},"2025-09-09",{"date":375,"type":34},"2025-09-01",{"date":377,"type":21},"2026-06-30",{"name":379,"class":41},"University of Toronto",{"id":381,"slug":382,"hasResults":11,"nctId":383,"briefTitle":384,"officialTitle":385,"acronym":4,"eligibilityCriteria":386,"healthyVolunteers":15,"sex":77,"minAge":17,"maxAge":387,"enrollmentInfo":388,"targetDuration":4,"studyType":22,"phases":390,"briefSummary":392,"conditions":393,"keywords":398,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":404,"lastUpdatePostDateStruct":405,"startDateStruct":407,"completionDateStruct":409,"leadSponsor":411,"locationsCount":42},"100602050","phase-4-highcycle-study-acetazolamide-high-altitude-and-plasma-volume-100602050","NCT07118462","HighCycle Study: Acetazolamide, High Altitude and Plasma Volume","HighCycle Study: Effect of Acetazolamide on Plasma Volume During Acute Exposure to High Altitude in Women and Men","Inclusion Criteria:\n\n* Healthy, non-smoking men and women, age 18-44 years, without any disease and need of regular medication (including oral contraceptives).\n* BMI \\>18 kg\u002Fm2 and \\\u003C30 kg\u002Fm2.\n* Born, raised and currently living at altitudes \\\u003C1000 m.\n* Written informed consent.\n* Premenopausal women with an eumenorrheic cycle.\n\nExclusion Criteria:\n\n* Other types of contraceptvies (contraceptives (hormonal intrauterine device, vaginal ring, subcutaneous injections or implants, among others).\n* Pregnancy or nursing\n* Anaemic (haemoglobin concentration \\\u003C10g\u002Fdl).\n* Any altitude trip \\\u003C4 weks before the study.\n* Allergy to acetazolamide and other sulfonamides.","44 Years",{"count":389,"type":21},270,[391],"PHASE4","Each year, millions of people living at low altitude (\\\u003C 1,000 m) travel to high altitude (≥ 2,500 m) for work, tourism, or sports activities. These individuals are exposed to hypobaric hypoxia, which can trigger acute mountain sickness (AMS)-the most common form of altitude-related illness. Therefore, understanding the physiological responses to hypoxia that allow acclimatization, as well as the pathophysiology of acute mountain sickness, is of primary importance.\n\nThe hematological response to high-altitude exposure initially includes a reduction in plasma volume (PV), leading to an early increase in hemoglobin concentration within the first 24 hours. In contrast, an increase in hemoglobin mass requires several weeks at high altitude. Recent well-controlled physiological studies conducted in hypobaric chambers have demonstrated that this hypoxia-induced PV contraction results from fluid redistribution from the intravascular to the extravascular compartment, rather than from water loss due to increased diuresis.\n\nProphylaxis of AMS is primarily based on the administration of 250 mg\u002Fday of acetazolamide (ACZ), a carbonic anhydrase inhibitor with a mild diuretic effect. Acetazolamide induces metabolic acidosis, which stimulates ventilation and thereby improves oxygenation. The effect of prophylactic ACZ use during high-altitude exposure on PV in lowlanders remains unknown: it is unclear whether ACZ leads to a greater reduction in PV due to its diuretic effect, or to a smaller hypoxia-induced PV contraction as a result of improved oxygenation induced by increased ventilation.",[394,395,396,397,27],"High Altitude Effects","High Altitude Hypoxia","Acute Mountain Sickness (AMS)","Plasma Volume",[399,400,401,402,403,285],"acetazolamide","plasma volume","acute mountain sickness","high altitude","hypoxia","2025-08-11",{"date":406,"type":34},"2025-08-12",{"date":408,"type":34},"2024-07-15",{"date":410,"type":21},"2025-12-31",{"name":412,"class":41},"Centre d'Expertise sur l'Altitude EXALT",{"id":414,"slug":415,"hasResults":11,"nctId":416,"briefTitle":417,"officialTitle":418,"acronym":419,"eligibilityCriteria":420,"healthyVolunteers":15,"sex":16,"minAge":421,"maxAge":303,"enrollmentInfo":422,"targetDuration":4,"studyType":22,"phases":424,"briefSummary":425,"conditions":426,"keywords":434,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":436,"lastUpdatePostDateStruct":437,"startDateStruct":439,"completionDateStruct":441,"leadSponsor":443,"locationsCount":42},"100569196","how-a-single-workout-affects-gut-bugs-in-women-with-different-fitness-levels-and-body-types-100569196","NCT06691100","How a Single Workout Affects Gut Bugs in Women With Different Fitness Levels and Body Types","The Acute Effects of an Endurance Exercise Bout the Gut Microbiome and Gut-derived Metabolome in Women's Distinct Fitness and Body Mass Indexes","FITGut-W","Inclusion Criteria:\n\n* Biological sex: female\n* BMI 19 to 24.99 kg\u002Fm2 or BMI 30-40 kg\u002Fm2\n* Exercisers: Exercise at least 4 times per week for 60 minutes (a total of 240 minutes per week) on a programmed exercise training either on endurance sports (e.g., running, cycling, triathlon), strength (e.g., powerlifting), or team sports (e.g., rugby, football, soccer)\n* Non-Exercisers: Sedentary individuals who have not reached the PA guidelines (150 minutes of moderate-intensity physical activity a week, 75 minutes of vigorous-intensity physical activity, or an equivalent combination of moderate and vigorous-intensity physical activity).\n\nExclusion Criteria:\n\n* Biological sex: male\n* BMI \\\u003C 19 kg\u002Fm2 or \\> 40 kg\u002Fm2\n* Currently pregnant, \\\u003C 2 years postpartum, lactating\n* Currently taking any herbal, fiber, or prebiotic supplement\n* Current or 1-month before the study, taking oral or vaginal antibiotics\n* Diagnosed with any gastrointestinal, endocrine, digestive, cancer, or cardiovascular disease.","21 Years",{"count":423,"type":21},40,[52],"This study aims to elucidate the differences in the gut microbiome functional activity and metabolome in adult premenopausal women with distinctive fitness levels and BMIs (with obesity, w\u002Fo obesity). The specific aims are as follows:\n\n* Aim 1: To examine the effects of acute aerobic exercise at 60-70% heart rate reserve (HRRmax) for 30 minutes bout on changes in the abundance of SCFA-producing bacteria and their functional downstream metabolic activity.\n* Aim 2: To examine the effects of acute aerobic exercise at 60-70% HRRmax 30-minute bout on changes in GM-released SCFA concentrations in stool and plasmatic metabolome.",[427,428,429,27,430,431,432,433],"Weight Management","Obesity","Exercise","Gut Microbiome","Metabolome","Health","Gut Microbiota",[433,435,429,427,428],"Womens Health","2025-07-22",{"date":438,"type":34},"2025-07-24",{"date":440,"type":34},"2024-10-16",{"date":442,"type":21},"2027-10-16",{"name":444,"class":41},"George Washington University",{"id":446,"slug":447,"hasResults":11,"nctId":448,"briefTitle":449,"officialTitle":450,"acronym":451,"eligibilityCriteria":452,"healthyVolunteers":11,"sex":77,"minAge":17,"maxAge":4,"enrollmentInfo":453,"targetDuration":4,"studyType":22,"phases":455,"briefSummary":456,"conditions":457,"keywords":462,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":470,"lastUpdatePostDateStruct":471,"startDateStruct":473,"completionDateStruct":475,"leadSponsor":477,"locationsCount":42},"100595885","patient-centered-personalized-cardiac-rehabilitation-in-post-acute-coronary-syndrome-break-trial-100595885","NCT07038265","Patient-centered Personalized Cardiac Rehabilitation in Post Acute Coronary Syndrome (BREAK-trial)","Patient-centered Cardiac rehaBilitation pRogramE in Post Acute Coronary Syndrome:Identification of Key Barriers and Evaluation of Personalized Intervention (BREAK-trial)","BREAK","Inclusion Criteria:\n\n1. Patient aged ≥ 18 years\n2. Patients discharged within the last 30 days after an admission for ACS or in the discharge planning process for an admission for ACS.\n3. The patient is able to fully communicate with the research team and comply with all study procedures.\n4. The patient voluntarily signs and dates the informed consent form approved by the ethics committee\n\nExclusion Criteria:\n\n1. Age \\\u003C18 years\n2. Participation in another clinical trial\n3. Moderate or severe cognitive impairment in the absence of a competent caregiver\n4. Absence of social support\n5. Institutionalized patient\n6. Life expectancy \\\u003C1 year\n7. Candidates for end-of-life care\n8. Severe psychiatric illness\n9. Planned cardiac surgery including transplant or circulatory support implant\n10. Death before hospital discharge in patients included in the hospital discharge planning phase\n11. Carrier of heart transplant.\n12. Patient unable or refusing to give written informed consent to participate\n13. Patients who, in the opinion of the investigator, are unsuitable candidates for the study",{"count":454,"type":21},202,[52],"The primary objective of this study is to compare an integrated, multidisciplinar patient-centered CRP (Cardiac Rehabilitation Program) (intervention group) especially focused on covering the needs for the female and fragile population to the usual care conventional CRP (control group)",[458,459,460,27,461],"Acute Coronary Syndromes (ACS)","Cardiac Rehabilitation","Frailty","Women's Health",[463,464,465,466,467,468,469],"frailty","sarcopenia","cardiac rehabilitation","gender perspective","acute coronary syndrome","coronary artery disease","patient-centered care","2025-06-17",{"date":472,"type":34},"2025-06-26",{"date":474,"type":34},"2025-05-26",{"date":476,"type":21},"2027-11",{"name":478,"class":41},"Institut d'Investigació Biomèdica de Bellvitge",{"id":480,"slug":481,"hasResults":11,"nctId":482,"briefTitle":483,"officialTitle":484,"acronym":4,"eligibilityCriteria":485,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":486,"enrollmentInfo":487,"targetDuration":4,"studyType":22,"phases":488,"briefSummary":489,"conditions":490,"keywords":4,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":494,"lastUpdatePostDateStruct":495,"startDateStruct":497,"completionDateStruct":499,"leadSponsor":500,"locationsCount":42},"100589698","preoperative-pelvic-floor-muscle-training-in-female-urinary-incontinence-100589698","NCT06957795","Preoperative Pelvic Floor Muscle Training in Female Urinary Incontinence","Investigation of the Preoperative Effectiveness of Intensive Pelvic Floor Muscle Training in Women With Urinary Incontinence: a Randomized Controlled Trial.","Inclusion criteria for the study:\n\n* Being a woman between the ages of 18-65\n* Being diagnosed with SUI or SUI-predominant mixed type urinary incontinence by an obstetrician-gynecologist\n* Having active pelvic floor muscle contraction\n* No genital anatomical abnormality\n* Being able to understand and follow verbal and written instructions\n* The patient was referred to physiotherapy at least 6 weeks before the planned surgery date\n* Patients performed 75% or more of the given exercises (categorized as adequate compliance)\n\nExclusion criteria for the study:\n\n* Not volunteering to participate\n* Being pregnant\n* Having had previous pelvic floor surgery\n* Having received previous pelvic floor physiotherapy\n* Having a vaginal or urinary infection\n* Being unable to tolerate pelvic floor muscle function measurement\n* Having a neuromuscular or neurological disease that may affect muscle function","65 Years",{"count":20,"type":21},[52],"Pelvic floor muscles (PFM) play a crucial role in supporting pelvic organs and maintaining continence. Weakness in these muscles can lead to dysfunctions such as pelvic organ prolapse, urinary incontinence (UI), and sexual or anorectal disorders. UI, defined as the involuntary loss of urine, is common globally and classified as stress, urge, or mixed incontinence. Stress urinary incontinence (SUI) - the most prevalent type among women - occurs during activities that increase intra-abdominal pressure. Risk factors include female sex, aging, obesity, smoking, chronic constipation, previous gynecological surgeries, and childbirth. Treatment options for SUI include conservative and surgical methods. Pelvic floor training (PFT), first described by Arnold Kegel in 1948, is a conservative approach that strengthens PFM and alleviates symptoms. Although surgery is often used for SUI, with over 200 procedures described, this study aims to evaluate the preoperative effectiveness of intensive PFT in women with SUI. It will assess changes in muscle function and symptoms before surgery, guiding pelvic rehabilitation strategies to potentially reduce surgical burden and improve outcomes.",[27,491,492,493],"Urinary Incontinence (UI)","Pelvic Floor Muscle Training","Preoperative Period","2025-05-05",{"date":496,"type":34},"2025-05-08",{"date":498,"type":34},"2025-01-01",{"date":375,"type":21},{"name":501,"class":41},"Gulhane School of Medicine",{"id":503,"slug":504,"hasResults":11,"nctId":505,"briefTitle":506,"officialTitle":507,"acronym":4,"eligibilityCriteria":508,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":509,"targetDuration":4,"studyType":80,"phases":4,"briefSummary":511,"conditions":512,"keywords":4,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":514,"lastUpdatePostDateStruct":515,"startDateStruct":517,"completionDateStruct":518,"leadSponsor":520,"locationsCount":42},"100582709","examination-of-the-effect-of-nocturia-on-pelvic-floor-symptoms-sleep-parameters-and-quality-of-life-in-women-with-urinary-incontinence-100582709","NCT06866834","Examination of the Effect of Nocturia on Pelvic Floor Symptoms, Sleep Parameters and Quality of Life in Women with Urinary Incontinence","Examination of the Effect of Nocturia on Pelvic Floor Symptoms, Chronotype, Sleepiness, Sleep Quality, Fatigue and Quality of Life in Women with Urinary Incontinence","Inclusion Criteria:\n\nInclusion Criteria for the Group with Nocturia:\n\n* Being 18 years of age or older\n* Being female\n* Have been diagnosed with urinary incontinence\n* Wake up during the main sleep period to relieve the need to urinate, with the intention of returning to sleep or falling asleep again after each urination\n\nInclusion Criteria for the Group without Nocturia:\n\n* Being 18 years of age or older\n* Being female\n* Have been diagnosed with urinary incontinence\n\nExclusion Criteria:\n\nExclusion Criteria for the Group with Nocturia:\n\n* Diagnosis of a sleep disorder\n* Diagnosis of any neurological disease\n* Chronic kidney disease\n* Diagnosis of diabetes\n* Use of sleep medications\n* Use of antidepressants\n* Use of diuretic medications\n* Use of any medication for urinary incontinence\n* Hormone replacement therapy\n* Pregnancy or having given birth within the last six months\n* Having had a urinary tract infection in the last three months\n* Presence of prolapse greater than stage 2\n* History of orthopedic trauma to the pelvic region\n* Pelvic surgery within the last six months\n* History of cancer\n\nExclusion Criteria for the Group without Nocturia:\n\n* Waking up during the main sleep period to relieve the need to urinate, with the intention of returning to sleep or falling asleep again after each urination\n* Diagnosis of a sleep disorder\n* Diagnosis of any neurological disease\n* Chronic kidney disease\n* Diagnosis of diabetes\n* Use of sleep medications\n* Use of antidepressants\n* Use of diuretic medications\n* Use of any medication for urinary incontinence\n* Hormone replacement therapy\n* Pregnancy or having given birth within the last six months\n* Having had a urinary tract infection in the last three months\n* Presence of prolapse greater than stage 2\n* History of orthopedic trauma to the pelvic region\n* Pelvic surgery within the last six months\n* History of cancer",{"count":510,"type":21},102,"Urinary incontinence (UI), a common issue, is the involuntary leakage of urine that negatively affects individuals socially, physically, and psychologically, leading to a decreased quality of life. Nocturia, which is often seen alongside UI, has similar adverse effects. Nocturia refers to the number of urinations during the main sleep period, and it should be accompanied by the intention to fall back asleep after waking up. Nocturia can arise from factors such as sleep disorders and circadian rhythm disturbances. The circadian rhythm regulates the body's biological functions, and this rhythm varies from person to person, creating chronotypes. There is a strong relationship between sleep and nocturia because nocturia leads to deep sleep loss, an increased risk of metabolic diseases, decreased sleep quality and sleep efficiency, and an increase in the number of awakenings after sleep onset. It is necessary to distinguish whether nocturia, which has a comprehensive impact, affects pelvic floor symptoms, chronotype, sleep quality, fatigue, sleepiness, and quality of life in women with UI. Therefore, the aim of this study is to examine the effect of nocturia on pelvic floor symptoms, chronotype, sleepiness, sleep quality, fatigue, and quality of life in women with UI.",[27,491,513],"Nocturia","2025-03-04",{"date":516,"type":34},"2025-03-10",{"date":498,"type":34},{"date":519,"type":21},"2025-06-01",{"name":501,"class":41},{"id":522,"slug":523,"hasResults":11,"nctId":524,"briefTitle":525,"officialTitle":526,"acronym":527,"eligibilityCriteria":528,"healthyVolunteers":15,"sex":16,"minAge":303,"maxAge":529,"enrollmentInfo":530,"targetDuration":4,"studyType":22,"phases":531,"briefSummary":532,"conditions":533,"keywords":538,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":540,"lastUpdatePostDateStruct":541,"startDateStruct":543,"completionDateStruct":545,"leadSponsor":547,"locationsCount":4},"100575170","web-app-based-lifestyle-physical-activity-promotion-program-wpapp-for-middle-aged-latinas-100575170","NCT06768801","Web-app Based Lifestyle Physical Activity Promotion Program (WPAPP) for Middle Aged Latinas","Pilot RCT of the Web-app Based Lifestyle Physical Activity Promotion Program (WPAPP) for Middle Aged Latinas","WPAPP-Latina","Inclusion Criteria: women aged 40-60 who self-identify as Latina or Hispanic women, are able to read and write in English or Spanish, live in the United States, and can use the app and complete online data collection using a smart phone, tablet, or computer.\n\n\\-\n\nExclusion Criteria: pregnancy within 3 months of starting the study, having or being of high risk for cardiovascular or musculoskeletal illnesses or injuries\n\n\\-","60 Years",{"count":423,"type":21},[52],"The purpose of the proposed project is to conduct a pilot randomized controlled trial (RCT) of the Web-App based Lifestyle Physical Activity Promotion Program (WPAPP) for middle-aged Latinas. The WPAPP is a web application (app) to promote lifestyle physical activity that was developed and tested with Korean American middle aged women. It shows promise for effectiveness with Latinas. The specific aims are:\n\n1. To test the feasibility and satisfaction of the WPAPP modified for Latinas.\n2. To examine preliminary effectiveness of the WPAPP-Latina on increasing physical activity and decreasing depressive symptoms.",[534,27,535,536,537],"Middle Aged","Depressive Symptoms","Physical Activity","Hispanic or Latino",[539],"Web-based App","2025-01-06",{"date":542,"type":34},"2025-01-10",{"date":544,"type":21},"2025-03",{"date":546,"type":21},"2025-09",{"name":548,"class":41},"University of Texas at Austin",{"id":550,"slug":551,"hasResults":11,"nctId":552,"briefTitle":553,"officialTitle":553,"acronym":4,"eligibilityCriteria":554,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":555,"enrollmentInfo":556,"targetDuration":4,"studyType":22,"phases":558,"briefSummary":559,"conditions":560,"keywords":562,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":567,"lastUpdatePostDateStruct":568,"startDateStruct":570,"completionDateStruct":572,"leadSponsor":574,"locationsCount":4},"100573007","effects-of-ve-focus-expressive-touch-on-pain-anxiety-breastfeeding-and-mobilization-in-women-delivering-by-cesarean-section-100573007","NCT06740669","Effects of VE, Focus, Expressive Touch on Pain, Anxiety, Breastfeeding and Mobilization in Women Delivering by Cesarean Section","Inclusion Criteria:\n\n\\- Women who do not have any psychiatric illness,\n\n* Those who do not have any vision, hearing or perception problems,\n* Those who do not have any communication problems (can speak Turkish),\n* Those who accept to participate in the study verbally and in writing were included in the study.\n* Those who are between the ages of 18-35,\n* Those who have had a singleton birth,\n* Those who have had the operation with regional anesthesia (spinal or epidural anesthesia),\n\nExclusion Criteria:\n\n* Exclusion Criteria from the Study\n\n  * Receiving controlled analgesia after cesarean section\n  * Having a psychiatric diagnosis such as anxiety and depression\n  * Those who develop postpartum complications\n  * Women who want to leave the study at any stage of the study will be excluded from the study","35 Years",{"count":557,"type":21},208,[52],"Cesarean section is one of the most common surgical interventions in many countries. It is seen that 21.1% of women worldwide, 57.5% in Turkey, give birth by cesarean section. 99.6% of women have pain in the first 24 hours after cesarean section and oral analgesia is not sufficient for pain. It is seen that pain has an effect on recovery and breastfeeding after CS.This study will be conducted to determine the effects of non-pharmacological methods, virtual reality glasses, focusing and expressive touch on pain, anxiety, breastfeeding and mobilization in women giving birth by cesarean section. The ınvestigators aim to contribute to the midwifery and nursing care literature with the findings and results of the study.",[27,561],"Postnatal Care",[563,564,565,59,56,566],"Virtual reality,","Focus","Expressive touch","Breastfeeding","2024-12-17",{"date":569,"type":34},"2024-12-18",{"date":571,"type":21},"2024-12-20",{"date":573,"type":21},"2025-05-30",{"name":575,"class":41},"Burdur Mehmet Akif Ersoy University",{"id":577,"slug":578,"hasResults":11,"nctId":579,"briefTitle":580,"officialTitle":580,"acronym":581,"eligibilityCriteria":582,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":583,"targetDuration":4,"studyType":22,"phases":585,"briefSummary":586,"conditions":587,"keywords":591,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":595,"lastUpdatePostDateStruct":596,"startDateStruct":598,"completionDateStruct":600,"leadSponsor":602,"locationsCount":604},"100510952","study-of-the-prevalence-of-sexual-dysfunction-in-women-after-rectal-cancer-surgery-and-analysis-of-the-impact-of-a-sexologist-intervention-100510952","NCT05933122","Study of the Prevalence of Sexual Dysfunction in Women After Rectal Cancer Surgery and Analysis of the Impact of a Sexologist Intervention","RectSexQol","Inclusion Criteria:\n\n* Women\n* Diagnosis of stage I-III rectal adenocarcinoma or rectosigmoid junction with anastomosis less than 15 cm from the anal margin\n* Surgical management, preceded or not by Radio-chemotherapy, with restoration of continuity\n* Age : over 18\n* Proficiency in French or English\n\nExclusion Criteria:\n\n* Current pregnancy\n* Significant cognitive\u002Fpsychiatric disorders\n* Guardianship",{"count":584,"type":21},144,[52],"RectSexQoL is a study aiming at determining the prevalence of female sexual dysfunction after rectal cancer surgery. It has the goal as well to analyse the impact of an intervention given by a sexologist to such patients.",[588,27,589,590],"Rectal Tumor","Sexuality","Life Quality",[592,285,593,594],"rectal cancer","sexuality","quality of life","2024-11-27",{"date":597,"type":34},"2024-12-02",{"date":599,"type":34},"2024-04-03",{"date":601,"type":21},"2027-10",{"name":603,"class":41},"University Hospital, Limoges",6,{"id":606,"slug":607,"hasResults":11,"nctId":608,"briefTitle":609,"officialTitle":610,"acronym":611,"eligibilityCriteria":612,"healthyVolunteers":11,"sex":16,"minAge":529,"maxAge":4,"enrollmentInfo":613,"targetDuration":4,"studyType":22,"phases":614,"briefSummary":615,"conditions":616,"keywords":619,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":624,"lastUpdatePostDateStruct":625,"startDateStruct":627,"completionDateStruct":629,"leadSponsor":631,"locationsCount":42},"100566465","effects-of-an-exercise-program-in-women-over-60-yr-with-hfpef-and-sarcopenia-on-functional-capacity-and-quality-of-life-100566465","NCT06655532","Effects of an Exercise Program in Women Over 60 yr. With HFpEF and Sarcopenia on Functional Capacity and Quality of Life","Effects of a Concurrent Training-based Exercise Program in Women Over 60 Years With Heart Failure With Preserved Ejection Fraction and Sarcopenia on Functional Capacity, Quality of Life and Cognitive Function","TRAIN-SARC","Inclusion Criteria:\n\n* Patients diagnosed with heart failure with preserved ejection fraction according to 2021 ESC guidelines for Heart Failure, with N-terminal pro-B-type natriuretic peptide (NT-proBNP) \\>125 pg\u002FmL, inthe last month.\n* Stable symptomatic heart failure patients (New York Heart Association functional class II-III) during the last month.\n* Age ≥ 60 years old.\n* The participant is willing to give informed consent to participate in the study.\n* SARC-F score ≥4 points.\n\nExclusion Criteria:\n\n* Inability to perform a valid baseline cardiopulmonary exercise test.\n* Cardiac pacemaker.\n* Significant primary moderate-to-severe valve disease.\n* Effort angina or signs of ischemia during CPET.\n* Primary cardiomyopathies.\n* Cardiac transplantation.\n* Any other comorbidity with a life expectancy of less than one year.",{"count":423,"type":21},[52],"This prospective study will randomize (1:1) women with heart failure with preserved ejection fraction (HFpEF) and sarcopenia to receive standard management alone or a combined 12-week supervised exercise program (combining aerobic and strength exercise) carried out in a single centre.\n\nAfter randomization, patients will be clinically evaluated. The primary endpoint (peakVO2) will be assessed by cardiopulmonary exercise testing (CPET) at 12 weeks. Women over 60 with HFpEF, functional class NYHA class II-III, and sarcopenia criteria will be enrolled. A sample size estimation \\[alfa: 0.05, power: 80%, a 20% loss rate, and at least a delta change of mean peakVO2: +1.9 mL\u002Fkg\u002Fmin (SD±2)\\] of 40 patients (20 per arm) would be necessary to test our hypothesis.",[617,618,27],"Heart Failure With Preserved Ejection Fraction (HFpEF)","Sarcopenia",[620,618,621,622,623,27],"Heart Failure with Preserved Ejection Fraction","Cardiovascular Diseases","Heart Diseases","Heart Failure","2024-10-23",{"date":626,"type":34},"2024-10-26",{"date":628,"type":21},"2024-11-04",{"date":630,"type":21},"2026-01-30",{"name":632,"class":41},"Fundación para la Investigación del Hospital Clínico de Valencia",{"id":634,"slug":635,"hasResults":11,"nctId":636,"briefTitle":637,"officialTitle":637,"acronym":4,"eligibilityCriteria":638,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":639,"targetDuration":4,"studyType":80,"phases":4,"briefSummary":640,"conditions":641,"keywords":4,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":646,"lastUpdatePostDateStruct":647,"startDateStruct":649,"completionDateStruct":651,"leadSponsor":652,"locationsCount":654},"100537321","protein-molecular-characteristics-and-prognosis-of-cervical-neuroendocrine-tumors-100537321","NCT06276309","Protein Molecular Characteristics and Prognosis of Cervical Neuroendocrine Tumors","Inclusion Criteria:\n\n1. Patients diagnosed with cervical neuroendocrine carcinoma by histopathology\n2. Clinical data were complete\n\nExclusion Criteria:\n\n1. Patients who are not being treated in our hospital\n2. Patients with lack of follow-up data, unable to obtain survival information\n3. Patients call to refuse to participate in this project\n4. The quality of paraffin specimens can not meet the requirements of proteome concentration determination",{"count":142,"type":21},"The clinical diagnosis and treatment data of 300 cases of cervical neuroendocrine tumors were collected, including age, preoperative biopsy pathology results, postoperative histopathological results, TCT results, and colposcopy biopsy pathology results. At the same time, paraffin tissue specimens (remaining specimens after pathological diagnosis) from 100 cases of cervical neuroendocrine tumors from multiple centers across the country were collected to establish a cervical neuroendocrine tumor data follow-up database. Protein concentration and omics analysis were performed on the data results, to evaluate the molecular characteristics and prognosis of cervical neuroendocrine tumor proteins, and to preliminarily explore its clinical application value.",[642,643,27,644,645],"Neuroendocrine Neoplasm","China","Cervical Cancer","Cervical Lesion","2024-09-12",{"date":648,"type":34},"2024-09-19",{"date":650,"type":34},"2024-02-01",{"date":152,"type":21},{"name":653,"class":41},"Fujian Maternity and Child Health Hospital",9,{"id":656,"slug":657,"hasResults":11,"nctId":658,"briefTitle":659,"officialTitle":660,"acronym":4,"eligibilityCriteria":661,"healthyVolunteers":15,"sex":16,"minAge":486,"maxAge":4,"enrollmentInfo":662,"targetDuration":4,"studyType":22,"phases":664,"briefSummary":665,"conditions":666,"keywords":670,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":673,"lastUpdatePostDateStruct":674,"startDateStruct":676,"completionDateStruct":677,"leadSponsor":679,"locationsCount":4},"100554947","the-effect-of-motivational-interviewing-based-health-behavior-training-in-chronically-ill-migrant-women-100554947","NCT06505707","The Effect of Motivational Interviewing-Based Health Behavior Training in Chronically Ill Migrant Women","The Effect of Health Seeking Behavior Training Based on Motivational Interviewing Techniques on Health Seeking Behavior, Illness Self-Management and Anxiety in Immigrant Elderly Women With Chronic Disease: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Migrant older women aged 65 years and older with chronic diseases,\n* Immigrant women who have been living in Turkey for at least six months and who may or may not have acquired citizenship,\n* Women who have no communication problems and who volunteered to be included in the study\n\nExclusion Criteria:\n\n* Women with dementia, Alzheimer's disease and diagnosed mental illness with a mini-mental test score below 24",{"count":663,"type":21},36,[52],"This randomized controlled experimental study will be conducted to investigate the effect of health seeking behavior training based on motivational interviewing techniques on health seeking behaviors, illness self-management and anxiety in migrant elderly women with chronic illness.\n\nHypotheses of the Study H11: Health-seeking behaviors training based on motivational interviewing techniques with migrant elderly women with chronic diseases will improve individuals' correct health-seeking behaviors.\n\nH12: Health seeking behaviors training based on motivational interviewing techniques with migrant elderly women with chronic diseases will increase individuals' disease self-management.\n\nH13: Health-seeking behaviors training based on motivational interviewing techniques with migrant elderly women with chronic diseases will reduce the anxiety level of individuals.\n\nIn the study, there will be an intervention group in which health-seeking behavior training based on motivational interviewing techniques will be applied and a control group in which no intervention will be applied.\n\nThe \"Migrant Elderly Women with Chronic Diseases\" in the intervention group, who will receive Health Seeking Behavior Training based on Motivational Interviewing Techniques, will be divided into four groups (the researcher conducting the intervention will interview the individuals in the 4 groups individually for 4 days). The interviews will be conducted 4 days a week (Monday, Tuesday, Thursday and Friday) and the Health Seeking Behavior Training Based on Motivational Interviewing Techniques, which lasts 4 weeks and each session is approximately 30-35 minutes, will be applied face-to-face.",[667,668,669,27],"Motivational Interviewing","Health Care Seeking Behavior","Migrants",[671,672,56],"Elderly","Self Efficacy","2024-07-11",{"date":675,"type":34},"2024-07-17",{"date":408,"type":21},{"date":678,"type":21},"2024-12-15",{"name":680,"class":41},"Kahramanmaraş İstiklal University",{"id":682,"slug":683,"hasResults":11,"nctId":684,"briefTitle":685,"officialTitle":685,"acronym":686,"eligibilityCriteria":687,"healthyVolunteers":11,"sex":16,"minAge":303,"maxAge":529,"enrollmentInfo":688,"targetDuration":4,"studyType":80,"phases":4,"briefSummary":690,"conditions":691,"keywords":4,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":694,"lastUpdatePostDateStruct":695,"startDateStruct":697,"completionDateStruct":698,"leadSponsor":700,"locationsCount":42},"100552115","analyzing-gait-parameters-among-women-with-and-without-stress-urinary-incontinence-100552115","NCT06468891","Analyzing Gait Parameters Among Women With and Without Stress Urinary Incontinence","GPWSUI","Inclusion Criteria:\n\n* Age between 40-60 years old.\n* Women with BMI ≥30.\n* Women are free from any other gynecological disorders or symptoms that may affect the results of the study.\n* All participants who will be enrolled in the study sign the informed consent form.\n* All participants will be of multiparas.\n* All participants will be diagnosed with a mild degree of stress urinary incontinence.\n\nExclusion Criteria:\n\n* Pregnancy\n* Neurological Disorders: such as Parkinson's disease , multiple sclerosis, or any neurological dysfunction that may affect the gait parameters\n* Musculoskeletal disorders: such as severe osteoarthritis or lower limb amputations\n* Significant cognitive impairment: or dementia\n* Previous pelvic surgery as pelvic organ prolapse repair or anti-incontinence procedures.\n* Other significant medical conditions that could affect gait include severe cardiovascular disease or severe respiratory conditions.\n* Walking pain.",{"count":689,"type":21},124,"This study will contribute to the existing body of knowledge on stress urinary incontinence and its impact on gait. The findings may have implications for the development of targeted interventions and rehabilitation strategies to improve mobility and quality of life in women with stress urinary incontinence",[692,693,27],"Gait","Stress Urinary Incontinence","2024-06-16",{"date":696,"type":34},"2024-06-21",{"date":694,"type":34},{"date":699,"type":21},"2024-08-30",{"name":701,"class":41},"Cairo University"]