[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"work-of-breathing\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:work-of-breathing":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,47,64,83],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100629087","the-role-of-environmental-temperatures-in-respiratory-control-100629087",false,"NCT07470086","The Role of Environmental Temperatures in Respiratory Control","Optimizing Mind-Body Interactions in Respiratory Control During Operationally Relevant Environmental Stressors","Inclusion Criteria:\n\n* Between the ages of 18-40 years old.\n* English speaking and reading.\n* Self-reported weekly activity of at least 120 minutes\u002Fweek of high intensity exercise for the previous 2 years.\n* Normal pulmonary function assessed by a resting forced expiratory volume in 1 second over forced vital capacity (FEV1\u002FFVC) \\> 75% of predicted.\n* Normal cognitive function assessed using the Montreal cognitive function test \\[18\\].\n* Body mass index (BMI) ≤ 35 kg\u002Fm2.\n* Females with a regular menstrual cycle that ranges from 21-35 days (eumenorrhea)\n\nExclusion Criteria:\n\n* History of smoking or recreational smoking, cardiovascular disease, renal disease, pulmonary disease (including asthma or exercise-induced asthma), neurological disease, and metabolic disease.\n* Are pregnant or could possibly be pregnant by self-report.\n* Are color blind.\n* Known allergy or hypersensitivity latex.\n* Take selective serotonin reuptake inhibitors, stimulant medication, antibiotics, and chronically consume pain medication (Aleve, Tylenol, etc.).\n* Resting blood pressure of \\> 130mmHg systolic or 90 mmHg diastolic and\u002For resting pulse rate of \\> 100 bpm.\n* Females with irregular menstrual cycles (oligomenorrhea) that ranges from 36-90 days, and females with the absence of a menstrual cycle (amenorrhea).\n* Taking birth control for the sole purpose of period cessation (eg., Mirena IUD)",true,"ALL","18 Years","40 Years",{"count":21,"type":22},15,"ESTIMATED","INTERVENTIONAL",[25],"NA","Warfighters are frequently exposed to environments and life-support systems that increase breathing resistance and the work of breathing (WOB), such as aircraft on-board oxygen generation systems and underwater breathing apparatuses. Elevated WOB increases the perception of breathing difficulty (dyspnea) and has been associated with impaired cognitive performance, including slower reaction time and reduced accuracy during attention-demanding tasks. These effects are particularly concerning in operational settings that require rapid decision-making and precise motor responses.\n\nDespite growing recognition of this issue, critical gaps remain regarding strategies to mitigate the perceptual and cognitive consequences of elevated inspiratory resistance, especially under realistic operational stressors. The objective of this study is to determine whether exposing individuals to thermal stress alters breathing perception and cognitive performance during inspiratory resistance. Participants will perform inspiratory resistance breathing under thermoneutral, heat, and cold conditions to determine whether thermal stress amplifies WOB, breathing perception, and cognitive impairment.",[28],"Work of Breathing",[30,31,32,33],"Inspiratory Resistance","Dyspnea Perception","Cognitive Performance","Thermal Stress","NOT_YET_RECRUITING","2026-03-10",{"date":37,"type":38},"2026-03-13","ACTUAL",{"date":40,"type":22},"2028-10-01",{"date":42,"type":22},"2029-12-31",{"name":44,"class":45},"Indiana University","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":52,"targetDuration":4,"studyType":23,"phases":53,"briefSummary":54,"conditions":55,"keywords":56,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":58,"startDateStruct":59,"completionDateStruct":61,"leadSponsor":63,"locationsCount":46},"100629088","the-role-of-breathing-perception-in-respiratory-control-100629088","NCT07470099","The Role of Breathing Perception in Respiratory Control",{"count":21,"type":22},[25],"Warfighters are frequently exposed to environments and life-support systems that increase breathing resistance and the work of breathing (WOB), such as aircraft on-board oxygen generation systems and underwater breathing apparatuses. Elevated WOB then increases the perception of breathing difficulty (dyspnea) and has been associated with impaired cognitive performance, including slower reaction time and reduced accuracy during attention-demanding tasks. These effects are particularly concerning in operational settings that require rapid decision-making and precise motor responses.\n\nDespite growing recognition of this issue, critical gaps remain regarding strategies to mitigate the perceptual and cognitive consequences of elevated inspiratory resistance, especially under realistic operational stressors. The objective of this experiment is to determine whether modifying the sensory perception of breathing alters breathing perception and cognitive performance during inspiratory resistance. Auditory feedback of ventilation will be manipulated (normal, reduced, or amplified) to assess whether altering breathing-related sensory input affects breathing perception and cognitive performance without changing mechanical load.",[28],[31,32,57],"Auditory Distraction",{"date":37,"type":38},{"date":60,"type":22},"2027-06-01",{"date":62,"type":22},"2028-09-30",{"name":44,"class":45},{"id":65,"slug":66,"hasResults":11,"nctId":67,"briefTitle":68,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":69,"targetDuration":4,"studyType":23,"phases":70,"briefSummary":72,"conditions":73,"keywords":74,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":76,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":46},"100625544","phase-4-the-role-of-heliox-in-respiratory-control-100625544","NCT07424014","The Role of Heliox in Respiratory Control",{"count":21,"type":22},[71],"PHASE4","Warfighters are frequently exposed to environments and life-support systems that increase breathing resistance and the work of breathing (WOB), such as aircraft on-board oxygen generation systems and underwater breathing apparatuses. Elevated WOB increases the perception of breathing difficulty (dyspnea) and has been associated with impaired cognitive performance, including slower reaction time and reduced accuracy during attention-demanding tasks. These effects are particularly concerning in operational settings that require rapid decision-making and precise motor responses.\n\nDespite growing recognition of this issue, critical gaps remain regarding strategies to mitigate the perceptual and cognitive consequences of elevated inspiratory resistance, especially under realistic operational stressors. The objective of this study is to determine whether reducing mechanical WOB alters breathing perception and cognitive performance during inspiratory resistance. Participants will breathe either normal-density air or a low-density helium-oxygen gas mixture (heliox) to determine whether reducing mechanical WOB lowers perceived breathing effort and improves cognitive function.",[28],[30,31,32],"RECRUITING",{"date":77,"type":38},"2026-03-12",{"date":79,"type":38},"2026-02-03",{"date":81,"type":22},"2027-05-31",{"name":44,"class":45},{"id":84,"slug":85,"hasResults":11,"nctId":86,"briefTitle":87,"officialTitle":88,"acronym":89,"eligibilityCriteria":90,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":91,"targetDuration":4,"studyType":23,"phases":93,"briefSummary":94,"conditions":95,"keywords":100,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":102,"lastUpdatePostDateStruct":103,"startDateStruct":105,"completionDateStruct":107,"leadSponsor":109,"locationsCount":46},"100492233","electrical-activity-of-the-diaphragm-and-respiratory-mechanics-during-nava-100492233","NCT05689476","Electrical Activity of the Diaphragm and Respiratory Mechanics During NAVA","Evaluation of the Relationship Between Electrical Activity of the Diaphragm and Respiratory Mechanics During Neurally Adjusted Ventilatory Assist in Lung Transplant Patients and in Patients Affected by Acute Respiratory Failure.","NAVAMECH","Inclusion Criteria:\n\n* Age \\> 18 y.o.\n* Admission to ICU for post-operative monitoring after LTx or acute respiratory failure needing invasive mechanical ventilation\n* Presence of spontaneous breathing activity\n* Sedation titrated to a target RASS between 0 and -2\n* Written informed consent obtained\n\nExclusion Criteria:\n\n* Contraindication to nasogastric tube insertion (gastroesophageal surgery in the previous 3 months, gastroesophageal bleeding in the previous 30 days, history of esophageal varices, facial trauma)\n* Increased risk of bleeding with nasogastric tube insertion, due to severe coagulation disorders and severe thrombocytopenia ( i.e., INR \\> 2 and platelets count \\\u003C 70.000\u002Fmm3)\n* Severe hemodynamic instability (noradenaline \\> 0.3 μg\u002Fkg\u002Fmin and\u002For use of vasopressin)\n* Postoperative extracorporeal respiratory support (ECMO)\n* Pre-operative reconditioning of the transplanted lungs by means of ex-vivo lung perfusion (EVLP)\n* Lung retransplantation\n* Failure to obtain a stable EAdi signal",{"count":92,"type":22},40,[25],"Protective ventilatory strategy should be applied to reduce ventilator-induced lung injury (VILI) after Lung Transplantation (LTx) or in case of acute respiratory failure requiring invasive mechanical ventilation. Neurally Adjusted Ventilatory Assist (NAVA) is an assisted ventilation mode in which respiratory support is coordinated by the electrical activity of the diaphragm (EAdi). Aim of the study is to assess the physiological relationship between neural respiratory drive, as assessed by EAdi, and tidal volume, driving pressure, and mechanical power, at different levels of ventilatory assist, in the absence of pulmonary vagal afferent feedback or during acute respiratory failure. Additional parameters will be collected: Pmus, Pocc, transpulmonary pressure etc.",[28,96,97,98,99],"Lung Transplantation","Neurally Adjusted Ventilatory Assist","Ventilator-Induced Lung Injury","Acute Respiratory Failure (ARF)",[101,98,97],"Lung Injury","2025-07-01",{"date":104,"type":38},"2025-07-08",{"date":106,"type":38},"2022-12-27",{"date":108,"type":22},"2025-12-27",{"name":110,"class":45},"University of Padova"]