[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"wound-breakdown\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:wound-breakdown":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":4},"100624386","co2lift-and-t-junction-breakdown-rates-evaluation-after-breast-reduction-surgery-pilot-trial-100624386",false,"NCT07408960","CO2Lift and T-Junction Breakdown Rates Evaluation After Breast Reduction Surgery Pilot Trial","Evaluating the Effect of CO2Lift Pro® Carboxy Gel on T-Junction Breakdown Rates After Breast Reduction Surgery: A Feasibility Study","CO2-BREAST","Inclusion Criteria:\n\n* Female patients aged 18 to 85 years\n* Undergoing bilateral reduction mammoplasty using an inverted-T (Wise pattern) technique\n* American Society of Anesthesiologists (ASA) physical status classification I-III\n* Able and willing to provide informed consent\n* Willing and able to comply with study procedures and follow-up visits\n\nExclusion Criteria:\n\n* Prior radiation therapy to either breast\n* Prior breast reduction surgery to either breast\n* Known allergy or sensitivity to CO2Lift®, Vaseline®, or any of the ingredients\n* Pregnant or breastfeeding\n* History of immunosuppressive therapy\n* History of keloid formation\n* Active local or systemic infection at the time of surgery\n* Current smoker or history of substance abuse (including alcohol or illicit drugs)\n* Use of asymmetrical breast reduction techniques\n* Anticipated inability to complete follow-up or loss to follow-up","FEMALE","18 Years","85 Years",{"count":21,"type":22},10,"ESTIMATED","INTERVENTIONAL",[25],"NA","The goal of this pilot study is to determine the feasibility of a larger randomized controlled trial evaluating CO₂Lift® Pro Carboxy Gel to reduce wound breakdown after bilateral breast reduction in adult female patients undergoing elective bilateral breast reduction surgery. The main question it aims to answer is: Is it feasible to recruit, retain, and treat patients while maintaining blinding and monitoring safety?\n\nExploratory questions include: (1) Does CO₂Lift® reduce the incidence of wound breakdown compared with placebo? (2) Is CO₂Lift® safe and well-tolerated in the postoperative period?\n\nResearchers will compare CO₂Lift® applied to one breast to placebo (Vaseline®) applied to the contralateral breast to see if CO₂Lift® can improve wound healing and tissue oxygenation.\n\nParticipants will:\n\n* Undergo bilateral breast reduction surgery.\n* Receive CO₂Lift® on one breast and placebo on the other, starting immediately after surgery and daily in clinic from postoperative days 1 to 6.\n* Attend weekly postoperative follow-up visits for 12 weeks for wound assessment and monitoring of adverse events.\n* Have standardized photographs and near-infrared spectroscopy measurements taken to evaluate tissue oxygenation and healing.",[28,29,30,31],"Wound Breakdown","Breast Reduction","Surgical Wound","Breast Surgery","NOT_YET_RECRUITING","2026-02-10",{"date":35,"type":36},"2026-02-13","ACTUAL",{"date":38,"type":22},"2026-04-01",{"date":40,"type":22},"2027-12-31",{"name":42,"class":43},"University of Calgary","OTHER"]