[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"wound-complication\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:wound-complication":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,8,0,[8,45,83,111,140,171,197,228],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100542009","phase-3-incisional-negative-pressure-wound-therapy-to-reduce-infection-and-complications-in-high-risk-fractures-100542009",false,"NCT06337292","Incisional Negative Pressure Wound Therapy to Reduce Infection and Complications in High-Risk Fractures","Incisional Negative Pressure Wound Therapy to Reduce Infection and Complications in High-Risk Fractures: A Multicenter Randomized Controlled Trial","iVAC","Inclusion Criteria:\n\n1. All open or closed tibial plateau or pilon fractures treated operatively with internal fixation at high risk for complication. Any open Gustilo Type I, II or IIIA tibial shaft fracture treated definitively with internal or external fixation with or without ipsilateral leg compartment syndrome if at least one wound is primarily closed.\n2. We define high-risk fractures as those that are either:\n\n   * Closed fracture initially treated with an external fixator (with or without limited internal fixation) and treated definitive more than 3 days later after swelling has resolved;\n   * Any open type I, II or IIIA fracture, regardless of timing of definitive treatment;\n   * Any tibial plateau fracture associated with ipsilateral leg compartment syndrome fasciotomy wounds that has at least one wound primarily closed\n3. Requiring incision for fixation or debridement of 3 cm or greater.\n4. Patients 18 years of age or older\n\nExclusion Criteria:\n\n1. The study injury is already infected at time of study enrollment.\n2. Patient is unable to receive incisional NPWT for any reason.\n3. Patients who have already had definitive fixation prior to enrollment in the study.\n4. Severe problems with maintaining follow-up (e.g., patients who are homeless at the time of injury or those who are intellectually challenged without adequate family support or who are prisoners).\n5. The study injury is a Gustilo Type IIIB or IIIC open fracture.","ALL","18 Years",{"count":20,"type":21},352,"ESTIMATED","INTERVENTIONAL",[24],"PHASE3","This is a multi-center, pragmatic, parallel arm randomized controlled trial (RCT) of 352 patients with high-risk open or closed tibial plateau fracture, high-risk open or closed tibial pilon fracture, or open tibial shaft fracture with incision \\>3cm. Eligible participants will be randomized to receive either incisional negative pressure wound therapy (NPWT) or a non-suction standard-of-care wound dressing for their definitive wound management. The primary outcome will be a composite outcome to evaluate clinical status 3 months after randomization.",[27,28,29,30,31],"Fracture of Tibia","Wound Heal","Infected Wound","Wound Complication","Wound Dehiscence","RECRUITING","2026-05-07",{"date":35,"type":36},"2026-05-12","ACTUAL",{"date":38,"type":36},"2025-01-01",{"date":40,"type":21},"2028-12-31",{"name":42,"class":43},"Major Extremity Trauma Research Consortium","OTHER",6,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":52,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":53,"targetDuration":4,"studyType":22,"phases":55,"briefSummary":57,"conditions":58,"keywords":61,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":82},"100636175","using-woundpilot-to-support-wound-care-decisions-in-patients-with-chronic-wounds-100636175","NCT07562269","Using WoundPilot to Support Wound Care Decisions in Patients With Chronic Wounds","Evaluation of the Effect of WoundPilot on the Accuracy and Consistency of Clinical Decision-Making in Chronic Wound Care: A Randomized Parallel Vignette Study Among Primary Care Nurses","Inclusion Criteria:\n\n* Primary care nurses involved in wound care decision-making\n* Nurses working in home care or nursing home settings\n* Nurses who assess and\u002For adapt wound management in clinical practice\n* Nurses with a qualification corresponding to European Qualification Framework (EQF) level 5 or 6\n* Willing and able to provide informed consent\n\nExclusion Criteria:\n\n* Nurses not involved in wound care decision-making\n* Nurses not working in a primary care setting\n* Inability to understand the study procedures or complete the assessment tasks\n* Refusal or inability to provide informed consent",true,{"count":54,"type":21},40,[56],"NA","This study evaluates whether a digital decision support tool, called WoundPilot, can help primary care nurses make more accurate and consistent decisions when caring for patients with chronic wounds.\n\nIn daily practice, treatment decisions for chronic wounds can vary between clinicians, even when they assess the same patient. This variation may lead to delays in appropriate care, inconsistent treatment choices, or unnecessary referrals. WoundPilot was developed to guide clinicians through a structured wound assessment and link this assessment to clear treatment recommendations.\n\nIn this study, primary care nurses will assess a series of clinical cases either with or without the support of WoundPilot. Their decisions will be compared with an expert reference standard to determine whether the use of WoundPilot improves the accuracy of decisions and reduces differences between nurses.\n\nThe results of this study will help determine whether WoundPilot can support more consistent and evidence-based wound care in clinical practice.",[30,59,60],"Wound Care","Wound and Injuries",[62,63,64,65,66,67,68,69,70,71],"chronic wound","wound care","clinical decision-making","decision support system","WoundPilot","Primary Care Nursing","Wound Assessment","decision-making","clinical reasoning","hard-to-heal wound","NOT_YET_RECRUITING","2026-04-24",{"date":75,"type":36},"2026-05-01",{"date":77,"type":21},"2026-06-01",{"date":79,"type":21},"2026-09",{"name":81,"class":43},"University Ghent",1,{"id":84,"slug":85,"hasResults":11,"nctId":86,"briefTitle":87,"officialTitle":88,"acronym":89,"eligibilityCriteria":90,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":91,"targetDuration":4,"studyType":22,"phases":93,"briefSummary":94,"conditions":95,"keywords":97,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":110},"100299259","inpwt-on-wound-complications--clinical-outcomes-after-lower-extremity-sarcoma-surgery-preop-radiation-therapy-patients-100299259","NCT03175718","INPWT on Wound Complications & Clinical Outcomes After Lower Extremity Sarcoma Surgery Preop Radiation Therapy Patients","The Effect of INPWT on Wound Complications and Clinical Outcomes Following Lower Extremity Sarcoma Surgery in Patients Treated With Preoperative Radiation Therapy: A Multicentre Randomized Controlled Trial","VAC","Inclusion Criteria:\n\n* Patients 18 years of age and older and are able to provide written consent.\n* Patients with lower extremity soft tissue sarcoma confirmed by tissue pathology.Each patient must have local cross sectional imaging (CT or MRI) and a staging CT chest.\n* Patients eligible for treatment with preoperative radiation therapy followed by limb salvage surgery.\n* Patients for which a primary closure must be attained at the time of surgery.\n* Patient must be available for postoperative follow-up at the treating center.\n\nExclusion Criteria:\n\n* Patients who are less than 18 years of age.\n* Patients with a benign disease or with prior radiation to the anatomic region in the remote past (not associated with current treatment radiation plans).\n* Patients who underwent surgical amputation\n* Patients in which primary closure was not achieved (including free flaps and split thickness skin grafts).\n* Patients with a life expectancy less than 120 days.\n* Patients who have an allergy or sensitivity to adhesive dressings.",{"count":92,"type":21},291,[56],"Project Summary - Aggressive soft tissue cancers are commonly treated with radiation followed by surgery. These wounds have a very high rate of wound complications and infection (30%), resulting in more surgeries, longer hospital stays and complex nursing care. Previous research shows that negative pressure (vacuum) dressings applied to the incision at the end of surgery can reduce these complications. The Investigator and his team across Canada will perform a clinical trial comparing standard dressings to these vacuum dressings. The results of this study have the potential to immediately improve the quality of life of soft tissue cancer patients. It can also decrease the amount of time required in hospital and reduce the cost to the Canadian healthcare system.",[96,30],"Soft-tissue Sarcoma",[98,99,100],"Sarcoma","Wound","Therapy","2026-02-26",{"date":103,"type":36},"2026-03-02",{"date":105,"type":36},"2022-02-01",{"date":107,"type":21},"2028-01-28",{"name":109,"class":43},"Dr. J. Werier",2,{"id":112,"slug":113,"hasResults":11,"nctId":114,"briefTitle":115,"officialTitle":116,"acronym":117,"eligibilityCriteria":118,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":119,"targetDuration":4,"studyType":22,"phases":121,"briefSummary":123,"conditions":124,"keywords":127,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":131,"lastUpdatePostDateStruct":132,"startDateStruct":134,"completionDateStruct":136,"leadSponsor":138,"locationsCount":82},"100597995","phase-4-negative-pressure-wound-therapy-in-renal-transplant-100597995","NCT07065734","NEgative prEssure Wound Therapy in Renal Transplant","NEgative prEssure Wound Therapy in Renal Transplant - NEWER Trial","NEWER","Inclusion Criteria:\n\n* All patients submitted to kidney transplant\n\nExclusion Criteria:\n\n* Pediatric patients, those requiring surgical reinterventions within the first 90 days postoperative, patients allergic to NPWT components, orthotopic transplant",{"count":120,"type":21},150,[122],"PHASE4","This is a prospective study involving patients undergoing open renal transplant. Renal transplant recipients were randomly divided into two groups: the NPWT group, which received NPWT, and the Standard group, which received standard wound dressings.",[125,126,30],"Transplant Complication","Renal Transplant",[128,129,130],"transplant complication","renal transplant","wound complication","2025-07-10",{"date":133,"type":36},"2025-07-15",{"date":135,"type":36},"2023-01-01",{"date":137,"type":21},"2026-06-30",{"name":139,"class":43},"Centro Hospitalar De São João, E.P.E.",{"id":141,"slug":142,"hasResults":11,"nctId":143,"briefTitle":144,"officialTitle":145,"acronym":146,"eligibilityCriteria":147,"healthyVolunteers":11,"sex":17,"minAge":148,"maxAge":4,"enrollmentInfo":149,"targetDuration":4,"studyType":22,"phases":151,"briefSummary":153,"conditions":154,"keywords":156,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":162,"lastUpdatePostDateStruct":163,"startDateStruct":165,"completionDateStruct":167,"leadSponsor":169,"locationsCount":82},"100596647","phase-2-sarcoma-surgery-wound-complications-comparing-usual-versus-negative-pressure-dressing-100596647","NCT07048184","Sarcoma Surgery Wound Complications Comparing Usual Versus Negative Pressure Dressing","Sarcoma Surgery Wound Complications Comparing Usual Versus Negative Pressure Dressing: a Randomised Phase II Trial","SUNDIAL","Inclusion Criteria:\n\n* Sarcoma of the upper\u002Flower limb or torso requiring wide local excision, planned marginal excision or amputation\n* Able to provide informed consent\n* Aged 16 years or over\n* Able, and willing, to adhere to scheduled trial procedures and visit schedule\n\nExclusion Criteria:\n\n* Previous surgery to planned surgical field\n* Contra-indication to surgical excision of the tumour\n* Disseminated malignancy on pre-op radiological imaging\n* Post-radiation sarcoma\n* Allergy to adhesive dressing\n* Subjects who, in the opinion of the PI, will be unable to comply with follow-up","16 Years",{"count":150,"type":21},94,[152],"PHASE2","To compare the differences in clinical outcomes and health economics between standard absorbent dressings versus Negative Pressure Wound Therapy dressings following the surgical resection of sarcoma tumours.",[98,155,30],"Negative Pressure Therapy",[98,157,30,158,159,160,161],"Surgery","Negative Pressure Wound Therapy","NPWT","Dressing","Tumour Resection","2025-07-04",{"date":164,"type":36},"2025-07-09",{"date":166,"type":21},"2025-12-01",{"date":168,"type":21},"2027-09-30",{"name":170,"class":43},"NHS Greater Glasgow and Clyde",{"id":172,"slug":173,"hasResults":11,"nctId":174,"briefTitle":175,"officialTitle":176,"acronym":177,"eligibilityCriteria":178,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":179,"targetDuration":4,"studyType":22,"phases":181,"briefSummary":182,"conditions":183,"keywords":184,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":188,"lastUpdatePostDateStruct":189,"startDateStruct":191,"completionDateStruct":193,"leadSponsor":195,"locationsCount":82},"100326238","comparing-wound-complications-after-elective-abdominal-surgery-using-two-closure-techniques-100326238","NCT03527433","Comparing Wound Complications After Elective Abdominal Surgery Using Two Closure Techniques","A Randomized, Controlled Trial Comparing Wound COmplications in Elective Midline Laparotomies After FAscia Closure Using Two Different Techniques of Running Sutures: COFACTOR-trial","COFACTOR","Inclusion Criteria:\n\n* Age 18 years or older\n* Signed Informed Consent\n* Undergoing an elective laparotomy through a midline incision\n* Undergoing a midline laparoscopic procedure (midline laparoscopic extraction site)\n\nExclusion Criteria:\n\n* Emergency surgery\n* Laparotomy through an incision other than midline\n* Previous midline laparotomy\n* Presence of incisional or ventral hernia at time of laparotomy\n* Incisional hernia repair\n* Laparotomy surgery during pregnancy",{"count":180,"type":21},274,[56],"Wound complications, increased hospital stays and post-operative morbidity are all common following abdominal surgery. Abdominal closure complications are strongly associated with the closure technique and material used. The traditional closure technique used by surgeons is placing the wide and large stitches. A randomized controlled trial done in Sweden described a new closure technique in surgeries by placing the stitches closer to each other by using narrow. The results showed lower incidence of wound infections, hernias, and wound rupture. However, the study provides low quality evidence on the benefits of this new technique since it has numerous limitations like lack of standardization of suture size, lack of proper randomization, and heterogeneity in patient eligibility which will increase result bias. There is still a need for quality evidence on the effectiveness of this new closing technique procedure at decreasing wound complications after the operation.\n\nIn this trial the investigators will compare two techniques in the closure of abdominal wounds in patients undergoing abdominal surgery. The first technique will be the traditional closure technique currently used in abdominal surgery. The second technique will be using the new closure technique. The closure of abdominal wounds with small and close sutures using the new technique is expected to lower the incidence of hernia and wound complications as well as improve the quality of life of the patient. Potential candidates for the study are those who will be undergoing elective midline laparotomy at AUBMC. The patients and assessor of outcomes will be blinded and patients will be randomized to receive either the traditional or new closure operation technique. There are no anticipated risks for those participating in the study. All data and information collected will be kept confidential.\n\nHypothesis:\n\nClosure of abdominal fascia in elective midline laparotomy incisions with small and close sutures compared to closure with conventional wide and distant sutures results in lower rates of wound rupture, incisional hernia, and wound infection, and improved quality of life.\n\nSignificance:\n\nThe results of this study will allow surgeons to assess the role of a new abdominal closure technique in decreasing short and long term postoperative complications, for a commonly performed procedure. This trial will generate evidence-based conclusions.",[30],[185,186,187],"Incisional hernia","Wound infection","Midline laparotomy","2025-01-28",{"date":190,"type":36},"2025-01-29",{"date":192,"type":36},"2019-10-01",{"date":194,"type":21},"2025-12",{"name":196,"class":43},"American University of Beirut Medical Center",{"id":198,"slug":199,"hasResults":11,"nctId":200,"briefTitle":201,"officialTitle":202,"acronym":203,"eligibilityCriteria":204,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":205,"targetDuration":4,"studyType":22,"phases":207,"briefSummary":208,"conditions":209,"keywords":214,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":220,"lastUpdatePostDateStruct":221,"startDateStruct":223,"completionDateStruct":225,"leadSponsor":226,"locationsCount":82},"100530774","cosmetic-outcome-of-electrocautery-scalpel-and-peak-plasmablade-for-surgical-breast-incisions-100530774","NCT06191159","Cosmetic Outcome of Electrocautery, Scalpel and PEAK PlasmaBlade for Surgical Breast Incisions","A Randomized Controlled Trial Comparing the Cosmetic Outcome of Electrocautery, Scalpel and PEAK PlasmaBlade for Surgical Breast Incisions","SCPPB","Inclusion Criteria:\n\n* Patients having a total mastectomy with or without axilla surgical staging\n\nExclusion Criteria:\n\n* Patients having immediate breast reconstruction\n* Patients with a diagnosis of inflammatory breast cancer\n* History of keloid scar formation\n* History of connective tissue disorder (scleroderma or rheumatoid arthritis with skin involvement)\n* Patients with prior incision at the planned mastectomy site.\n* Patients with known suture hypersensitivity\n* Patients with evidence of current infection",{"count":206,"type":21},186,[56],"This study will compare the cosmetic scar result from the use of scalpel, electrocautery, and pulsed electron avalanche knife (PEAK) PlasmaBlade (PPB) for the initial skin incision for total mastectomy procedures without immediate breast reconstruction.\n\nIt is hypothesized that there will be no significant difference in mastectomy scar cosmesis.\n\nThe purpose and objectives of this study are:\n\n1. To evaluate and compare the cosmetic scar result from the use of scalpel, standard electrocautery, or PEAK PlasmaBlade for initial incision for total mastectomy procedures without immediate breast reconstruction.\n2. To inform future equipment choices for breast surgery including potential elimination of scalpels and their attendant risks.",[30,210,211,212,213],"Surgical Wound Infection","Post-operative Pain","Postoperative Complications","Scar",[215,216,217,218,219],"Electrocautery","PEAK PlasmaBlade","Scalpel","Mastectomy","Incision","2024-12-10",{"date":222,"type":36},"2024-12-16",{"date":224,"type":36},"2024-12-09",{"date":194,"type":21},{"name":227,"class":43},"University of British Columbia",{"id":229,"slug":230,"hasResults":11,"nctId":231,"briefTitle":232,"officialTitle":233,"acronym":234,"eligibilityCriteria":235,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":236,"enrollmentInfo":237,"targetDuration":4,"studyType":22,"phases":239,"briefSummary":240,"conditions":241,"keywords":246,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":247,"lastUpdatePostDateStruct":248,"startDateStruct":250,"completionDateStruct":252,"leadSponsor":254,"locationsCount":82},"100554225","morbidity-of-conventional-and-no-touch-saphenectomy-in-coronary-artery-bypass-grafting-100554225","NCT06496321","Morbidity of Conventional and No-touch Saphenectomy in Coronary Artery Bypass Grafting.","Morbidity of Conventional and No-touch Saphenectomy in Coronary Artery Bypass Grafting, a Randomized Non-inferiority Clinical Trial","TNT","Inclusion Criteria:\n\n* Patients undergoing coordination coronary revascularization surgery, in which it is necessary to use the internal saphenous vein as a conduit.\n\nExclusion Criteria:\n\n* Emergency surgeries.\n* Poor metabolic control (HbA1c \\> 6.5%).\n* Chronic venous insufficiency or chronic obstructive arteriopathy of the lower limbs.\n* Type II obesity (BMI\\>35).","70 Years",{"count":238,"type":21},52,[56],"A clinical research project will be carried out that will consist of a non-inferiority study. The objective is to compare the morbidity of two different surgical techniques for the extraction of the internal saphenous vein, intended to be used as a conduit in coronary bypass.",[242,243,244,245,30],"Saphenectomy","No Touch","Coronary Artery Disease","Cardiovascular Diseases",[242,243,244],"2024-07-08",{"date":249,"type":36},"2024-07-11",{"date":251,"type":36},"2024-03-15",{"date":253,"type":21},"2025-12-31",{"name":255,"class":43},"Instituto Nacional de Cirugia Cardiaca, Uruguay"]