[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"wound-healing-complication\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:wound-healing-complication":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,51,77,109],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":31,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":4},"100642717","prophylactic-use-of-cinpwt-in-gynecologic-laparotomy-100642717",false,"NCT07645547","Prophylactic Use of ciNPWT in Gynecologic Laparotomy","Implementation of Prophylactic Negative Pressure Wound Therapy (ciNPWT) in High-Risk Patients in Gynecologic Oncology: A Prospective Feasibility Study and Nested Qualitative Analysis","Inclusion Criteria:\n\n* Adult female patients scheduled for planned abdominal surgery for gynecologic or gynecologic-oncologic indications.\n\nIdentification as \"high-risk\" for wound healing complications based on a clinical risk screening at admission.\n\nSigned informed consent.\n\nExclusion Criteria:\n\n* Failure to provide informed consent.","FEMALE","18 Years",{"count":19,"type":20},30,"ESTIMATED","INTERVENTIONAL",[23],"NA","This is a prospective, open-label, non-randomized interventional feasibility study with a nested qualitative analysis. The study exploratively verifies the feasibility of targeted prophylactic closed incision negative pressure wound therapy (ciNPWT) in clinical practice for patients with a high predicted risk of wound healing complications and compares the 30-day incidence of postoperative complications with standard dressing.\n\nParticipants will:\n\n* Get ciNPWT or standard dressing after planned laparotomy\n* Answer the questionairs about qualite of life\n* Will visit the clinic 30 days after surgery to see the final result",[26,27,28,29,30],"Surgical Site Infection (SSI)","Wound Healing Complication","Seroma","Hematoma","Dehiscence",[32,33,34,35,36,37,38],"ciNPWT","laparotomy","surgical site infection","SSI","feasibility","PROMs","ASEPSIS","NOT_YET_RECRUITING","2026-06-11",{"date":42,"type":43},"2026-06-12","ACTUAL",{"date":45,"type":20},"2026-07",{"date":47,"type":20},"2028-12",{"name":49,"class":50},"University Hospital Hradec Kralove","OTHER",{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":57,"eligibilityCriteria":58,"healthyVolunteers":59,"sex":60,"minAge":17,"maxAge":4,"enrollmentInfo":61,"targetDuration":4,"studyType":21,"phases":63,"briefSummary":64,"conditions":65,"keywords":4,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":76},"100637697","subcutaneous-suture-versus-no-subcutaneous-suture-for-abdominal-wound-closure-100637697","NCT07615517","Subcutaneous Suture Versus no Subcutaneous Suture for Abdominal Wound Closure","Subcutaneous Suture Versus no Subcutaneous Suture for Abdominal Wound Closure in Abdominal Surgery","SUTURE","Inclusion Criteria:\n\n* Adult patients (≥18 years)\n* elective laparotomy (midline laparotomy, transverse laparotomy, subcostal incision, thoracoabdominal incision, or extended Pfannenstiel incision) or laparoscopically assisted abdominal surgery with a specimen extraction incision of at least 6 cm.\n\nExclusion Criteria:\n\n* Emergency laparotomy.\n* Anticipated or documented non-compliance with study procedures or follow-up.\n* Patients in whom primary wound closure cannot be achieved at the end of surgery.\n* Patients unable to provide informed consent.",true,"ALL",{"count":62,"type":20},655,[23],"Surgical site infections are among the most frequent complications after abdominal surgery and are associated with impaired wound healing, prolonged hospital stay, additional treatments, and increased healthcare costs. Closure of the subcutaneous tissue before skin closure is commonly performed in abdominal surgery, but the available evidence supporting this practice remains limited and heterogeneous, particularly outside caesarean section surgery.\n\nThe SUTURE trial is a prospective, randomized, patient- and assessor-blinded superiority trial evaluating whether subcutaneous tissue closure reduces the incidence of surgical site infections after abdominal surgery. Adult patients undergoing elective open or laparoscopically\u002Frobotically assisted abdominal surgery with an abdominal incision of at least 6 cm will be randomized intraoperatively after fascial closure to either subcutaneous tissue closure using interrupted Vicryl® 2-0 sutures or no subcutaneous tissue closure. The primary endpoint is the occurrence of surgical site infection according to CDC criteria grade I-II within 30 days after surgery.\n\nThe trial aims to provide high-quality evidence on whether routine subcutaneous tissue closure should be recommended as a standardized wound closure strategy in abdominal surgery.",[26,27],"RECRUITING","2026-05-22",{"date":69,"type":43},"2026-05-29",{"date":71,"type":43},"2026-03-23",{"date":73,"type":20},"2028-05-30",{"name":75,"class":50},"University Hospital Augsburg",1,{"id":78,"slug":79,"hasResults":11,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":83,"eligibilityCriteria":84,"healthyVolunteers":11,"sex":60,"minAge":17,"maxAge":4,"enrollmentInfo":85,"targetDuration":4,"studyType":21,"phases":87,"briefSummary":88,"conditions":89,"keywords":94,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":76},"100636878","intraoperative-application-of-cold-atmospheric-plasma-to-prevent-postoperative-wound-complications-in-the-inguinal-region-of-high-risk-patients-with-peripheral-arterial-occlusive-disease-100636878","NCT07571408","Intraoperative Application of Cold Atmospheric Plasma to Prevent Postoperative Wound Complications in the Inguinal Region of High-risk Patients With Peripheral Arterial Occlusive Disease","Prophylactic Application of Cold Atmospheric Plasma to Reduce Postoperative Wound Healing Disorders in the Inguinal Region in High-risk Patients With Peripheral Arterial Occlusive Disease- Intraoperative Application of Cold Atmospheric Plasma in the Inguinal Region","PICPAD","Inclusion Criteria:\n\n* Age \\> 18 years\n* Written informed consent\n* Surgical treatment of peripheral arterial occlusive disease (PAOD) with femoral (inguinal) access\n* High-risk patient for wound healing complications:\n\nWHD (wound healing disorder) score ≥ 4 points:\n\nDiabetes mellitus (2) Immunosuppression\u002Fsteroid therapy (2) End-stage renal disease (2) Reinterventions (2) Peripheral arterial occlusive disease (1) Nicotine abuse (1) Obesity (BMI \\> 30) (1) Age \\> 80 years (1) Duration of surgery \\> 4 h (1) Blood loss \\> 1.5 L (1) Local radiotherapy\u002Fchemotherapy (1)\n\nExclusion Criteria:\n\n* Pregnancy or breastfeeding\n* Femoral access for an indication other than PAOD\n* Preoperative local infection or infectious skin disease\n* Life expectancy \\\u003C 3 months\n* Active infection of the ipsilateral extremity requiring systemic antibiotic therapy at the time of surgery\n* Systemic antibiotic therapy at the time of surgery\n* Use of coated incisional drapes (e.g., iodine-impregnated)\n* Intraoperative use of anti-infective topical agents (e.g., Gentacoll, doxycycline, etc.)\n* Use of fibrin sealants\u002Fthrombogenic adhesive substances above the fascia Planned postoperative prophylactic negative pressure wound therapy (NPWT)",{"count":86,"type":20},214,[23],"The goal of this clinical trial is to learn if postoperative wound complications in the inguinal region of high-risk patients with peripheral arterial occlusive disease can be prevented by the intraoperative application of cold atmospheric plasma.\n\nThe main questions it aims to answer are:\n\nDoes the intraoperative application of cold atmospheric plasma reduce the need for surgical revision of inguinal wounds due to wound healing complications within 3 months postoperatively? Does the intraoperative application of cold atmospheric plasma reduce wound healing complications not requiring revision within 3 months postoperatively?\n\nResearchers will compare the application of cold atmospheric plasma to a placebo (a deactivated look-alike device).\n\nParticipants will:\n\nUndergo surgical treatment with femoral artery access due to their peripheral arterial occlusive disease, in accordance with the respective vascular surgery department standard of care.\n\nReceive a single application of cold atmospheric plasma or, respectively, placebo in the area of their inguinal access wound during surgery (after subcutaneous closure and prior to skin closure).\n\nBe regularly assessed for wound healing during the first postoperative 14 days as part of routine clinical care and undergo a final evaluation at 3 months. They will also be surveyed regarding their quality of life.",[90,91,27,92,93],"Peripheral Occlusive Disease","Wound Healing","Cold Atmospheric Plasma","Prevention",[95,96,97,98,99],"cold atmospheric plasma","prevention","wound healing disorder","vascular surgery","peripheral occlusive disease","2026-05-04",{"date":102,"type":43},"2026-05-06",{"date":104,"type":20},"2026-11-01",{"date":106,"type":20},"2029-06-01",{"name":108,"class":50},"Ursula Werra",{"id":110,"slug":111,"hasResults":11,"nctId":112,"briefTitle":113,"officialTitle":113,"acronym":4,"eligibilityCriteria":114,"healthyVolunteers":11,"sex":60,"minAge":17,"maxAge":4,"enrollmentInfo":115,"targetDuration":4,"studyType":21,"phases":117,"briefSummary":118,"conditions":119,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":123,"lastUpdatePostDateStruct":124,"startDateStruct":126,"completionDateStruct":128,"leadSponsor":130,"locationsCount":4},"100582534","comparison-of-three-types-of-sutures-in-oral-surgery-study-of-bacterial-colonization-tissue-reaction-and-clinical-characteristics-randomized-clinical-study-100582534","NCT06864559","Comparison of Three Types of Sutures in Oral Surgery. Study of Bacterial Colonization, Tissue Reaction and Clinical Characteristics: Randomized Clinical Study","Inclusion Criteria:\n\n* Patients with indication for extraction of a third lower molar retained in an unfavorable position that requires a bayonet incision in the surgical procedure.\n* Age: patients aged 18 years or older.\n* ASA I patients (Classification of the American Society of Anesthesiology, 1979): healthy patients who tolerate stress well, without systemic pathology, no anxiety and in whom a therapeutic modification is not necessary.\n\nExclusion Criteria:\n\n* Pregnant or breastfeeding women.\n* Smoking patients.",{"count":116,"type":20},24,[23],"Considering the wide variety of surgical sutures currently marketed in the field of Dentistry, it was decided to conduct a study comparing the microbial adhesion and antibacterial activity of three different types of sutures used in Oral Surgery (Silk, non-absorbable polyamide monofilament and non-absorbable expanded polytetrafluoroethylene).",[27,120,121,122],"Oral Surgery","Third Molar Extraction","Oral Infection","2025-03-03",{"date":125,"type":43},"2025-03-07",{"date":127,"type":20},"2025-03-01",{"date":129,"type":20},"2025-12-01",{"name":131,"class":50},"Universidad de Granada"]