[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"wound-infection\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:wound-infection":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,16,0,[8,48,77,106,128,159,189,224,252,277,310,334,363,388,423,450],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100630984","early-phase-1-topical-methylene-blue-photodynamic-therapy-mb-pdt-for-burn-wound-infection-100630984",false,"NCT07494773","Topical Methylene Blue-Photodynamic Therapy (MB-PDT) for Burn Wound Infection","Topical Methylene Blue-Photodynamic Therapy (MB-PDT) for Burn Wound Infection: A Prospective Randomized Pilot Study","Inclusion\n\n* Age ≥18\n* Partial- or full-thickness burn with partial-thickness component\n* Expected ≥7 days dressing changes\n* Able to consent\n\nExclusion\n\n* Pregnancy or lactation\n\n  o Pregnancy status will be determined by review of the medical record and, when clinically indicated per institutional policy, standard-of-care pregnancy testing. No additional pregnancy testing will be performed solely for research purposes.\n* Current use of SSRIs, SNRIs, MAO inhibitors, and other serotonergic agents\n* Inability to tolerate wound exposure\n* Inability to consent\n* Known glucose-6-phosphate dehydrogenase (G6PD) deficiency","ALL","18 Years",{"count":19,"type":20},50,"ESTIMATED","INTERVENTIONAL",[23],"EARLY_PHASE1","Burn wound infections remain a major source of morbidity in patients with thermal injuries and contribute to delayed healing, graft loss, and prolonged hospitalization. The emergence of antimicrobial-resistant organisms further complicates management and highlights the need for non-antibiotic antimicrobial strategies. Photodynamic therapy (PDT) is an antimicrobial approach that combines a photosensitizing agent with visible light to generate reactive oxygen species capable of killing bacteria.\n\nThis randomized clinical trial will evaluate the safety and preliminary efficacy of methylene blue-mediated photodynamic therapy for the treatment of burn wound bacterial contamination. Participants receiving standard burn care will be randomized to receive either methylene blue-photodynamic therapy with blue light illumination or light therapy alone during routine dressing changes. Treatments will occur during two consecutive dressing changes. The primary objective is to determine whether methylene blue photodynamic therapy reduces bacterial burden in burn wounds compared with light therapy alone. Secondary outcomes include safety, tolerability, and effects on wound healing.",[26,27],"Burns","Wound Infection",[29,30,31,32,33,34],"Photodynamic Therapy","Methylene Blue","Burn Wound Infection","Antimicrobial Photodynamic Therapy","Reactive Oxygen Species","Burn Wound Bacterial Burden","NOT_YET_RECRUITING","2026-05-14",{"date":38,"type":39},"2026-05-19","ACTUAL",{"date":41,"type":20},"2026-06",{"date":43,"type":20},"2028-05-31",{"name":45,"class":46},"University of Oklahoma","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":54,"targetDuration":4,"studyType":21,"phases":56,"briefSummary":58,"conditions":59,"keywords":64,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":47},"100631531","investigating-the-impact-of-cold-atmospheric-plasma-treatment-on-wound-healing-at-cannulation-sites-in-patients-following-extracorporeal-life-support-100631531","NCT07501897","Investigating the Impact of Cold Atmospheric Plasma Treatment on Wound Healing at Cannulation Sites in Patients Following Extracorporeal Life Support","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Receiving extracorporeal life support (ECLS)\n* Presence of cannulation site wound requiring wound care\n\nExclusion Criteria:\n\n* Pre-existing severe dermatological conditions at the cannulation site\n* Severe coagulopathy precluding local intervention\n* Concurrent receipt of other experimental wound treatments\n* Life expectancy \\\u003C 48 hours",{"count":55,"type":20},65,[57],"NA","This study aims to evaluate a new wound treatment called cold atmospheric plasma (CAP) for patients receiving extracorporeal life support (ECLS). Patients on extracorporeal life support (ECLS) often develop wounds at the sites where tubes are inserted, and these wounds can be difficult to heal and prone to infection.\n\ncold atmospheric plasma (CAP) is a gentle, non-heat treatment that can kill bacteria, reduce inflammation, and promote wound healing. In this study, patients will be randomly assigned to receive either standard wound care alone or standard care plus cold atmospheric plasma (CAP) treatment.\n\nResearchers will compare both groups to see whether cold atmospheric plasma (CAP) can reduce infection, improve healing speed, and decrease the need for additional procedures. The study will also monitor safety to ensure the treatment is well tolerated.\n\nThe goal is to find a more effective and safe way to improve wound healing in critically ill patients.",[60,27,61,62,63],"ExtraCorporeal Life Support (ECLS)","Surgical Site Infection","Delayed Wound Healing","Biofilm-Associated Infection",[65,66],"Extracorporeal Life Support","cold atmospheric plasma","RECRUITING","2026-03-25",{"date":70,"type":39},"2026-03-30",{"date":72,"type":39},"2026-03-12",{"date":74,"type":20},"2026-12-31",{"name":76,"class":46},"National Taiwan University Hospital",{"id":78,"slug":79,"hasResults":11,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":83,"eligibilityCriteria":84,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":85,"enrollmentInfo":86,"targetDuration":4,"studyType":21,"phases":88,"briefSummary":89,"conditions":90,"keywords":95,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":47},"100618245","healing-electroceutical-dressing-for-the-recovery-of-open-wounds-hero-100618245","NCT07329114","Healing Electroceutical Dressing for the Recovery of Open Wounds (HERO)","Prospective, Unblinded, Randomized, Controlled Investigation to Evaluate the Clinical Efficacy of PowerHeal™ Bioelectric Bandage in Managing Infected Traumatic Wounds","HERO","Inclusion Criteria:\n\n1. Female and male participants 18-105 years of age\n2. Hospital admission (or boarding in an emergency department or other area awaiting hospital admission) at participating clinical sites in Ukraine\n3. At least one infected traumatic wound(s) between 20-40 cm2 in size. Probable or confirmed wound infection(s) will be determined by on-site physicians' clinical judgment and the presence of two or more of the following clinical indicators of wound infection:\n\n   1. Presence of worsening pain (from the moment of injury)\n   2. Erythema (redness)\n   3. Warmth (heat)\n   4. Edema (swelling)\n   5. Purulent exudate (drainage)\n   6. Delayed healing\n   7. Discoloration\n   8. Friable granulation\n   9. Foul odor\n   10. Wound margin breakdown or necrosis with or without fever\n   11. Pustules, vesicles, boils\n4. Participant or legal representative provides written informed consent prior to investigation procedures\n5. Participant understands and agrees to adhere to planned investigation procedures\n\nExclusion Criteria:\n\n1. Allergy to silver or zinc\n2. Women who are pregnant or nursing\n3. Women of childbearing potential without a documented negative pregnancy test during the current hospitalization or women of childbearing potential who refused pregnancy testing during screening\n4. Sponsor or contract research organization (CRO) staff directly involved in the conduct of the investigation, and site staff supervised by the investigator, and their respective family members\n5. \\> 60 days from the initial traumatic injury\n6. Known prisoner\n7. The patient is expected to be discharged from the hospital within the next 24 hours\n8. Medical condition other than the acute traumatic wound (and its manifestations) that is likely to result in death within 14 days of randomization\n9. Moribund condition, defined as life expectancy less than 48 hours from randomization\n10. Patients undergoing comfort care measures only such that treatment focuses on end-of-life symptom management over prolongation of life\n11. Expected inability or unwillingness to participate in study procedures\n12. In the opinion of the investigator, participation in the investigation is not in the best interest of the patient\n\nNote: Allergies to parabens and acrylates will also be considered. While they are not direct exclusions, participants with these allergies should avoid being enrolled.","105 Years",{"count":87,"type":20},150,[57],"The goal of this clinical trial is to determine whether the wireless electroceutical dressing (WED) called PowerHeal™ Bioelectric Bandage, improves care of infected wounds by clearing the infection and helping the wound heal better.\n\nThe main hypotheses it aims to answer are:\n\n1. WED promotes wound closure, as determined by wound area measurement\n2. WED manages wound infection in civilian and military wounds in Ukraine, as determined by clinical assessment of wound infection by measuring the numbers and types of relevant microbes.\n\nResearchers will compare to see if PowerHeal™ Bioelectric Bandage the dressing used in the SOC group\n\nParticipants will get their dressings changed per the protocol, wound image and swab will be taken.",[91,27,92,93,94],"Wound Heal","Wound Healing Delayed","Wound of Skin","Infections",[96],"bandage","2026-03-04",{"date":99,"type":39},"2026-03-06",{"date":101,"type":39},"2026-02-11",{"date":103,"type":20},"2027-08",{"name":105,"class":46},"Chandan Sen",{"id":107,"slug":108,"hasResults":11,"nctId":109,"briefTitle":110,"officialTitle":110,"acronym":4,"eligibilityCriteria":111,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":112,"enrollmentInfo":113,"targetDuration":4,"studyType":21,"phases":115,"briefSummary":116,"conditions":117,"keywords":4,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":119,"lastUpdatePostDateStruct":120,"startDateStruct":122,"completionDateStruct":124,"leadSponsor":126,"locationsCount":47},"100580740","randomized-controlled-trial-on-the-efficacy-and-safety-of-xiang-lei-ointment-in-diabetic-related-ulcer-management-100580740","NCT06841237","Randomized Controlled Trial on the Efficacy and Safety of Xiang Lei Ointment in Diabetic-related Ulcer Management","Inclusion Criteria:\n\n* a confirmed diagnosis of type 1 or type 2 diabetes mellitus that meets the standard World Health Organization definition, with blood glucose controlled prior to enrolment and a glycated haemoglobin HbA1c level of less than 10%;\n* the type of wound is an ulcer;\n* the wound etiology is diabetic, mainly abnormalities in blood glucose, resulting in poor or prolonged healing and requiring standard wound therapy;\n* the staging of the wound is in the granulation phase;\n* voluntary participation in the study and signing of an informed consent form.\n\nExclusion Criteria:\n\n* acute heart attack, heart failure, hepatitis, shock, expiratory failure and other serious diseases that have not been corrected;\n* uncontrolled blood glucose, fasting blood glucose \\> 15 mmol\u002FL and glycated haemoglobin \\> 12%;\n* active bleeding in the wound, which does not allow the implementation of the conventional basic treatment plan;\n* serum albumin \\< 20 g\u002FL; haemoglobin \\< 60 g\u002FL; platelets \\< 50 x 109\u002FL;\n* a state of disseminated infection that is being or will be treated with antibiotics\n* patients with advanced malignant tumours;\n* active autoimmune disease;\n* previous allergy to topical human granulocyte macrophage stimulating factor gel (Jinfuning);\n* inability of the patient to co-operate or mental disorder;\n* in the judgement of the investigator, the subject has a clearly irremovable cause of wound healing, is unsuitable for the study or is unable to comply with the requirements of the study.","80 Years",{"count":114,"type":20},56,[57],"Diabetes is one of the major chronic diseases. Diabetic ulcers are important adverse outcomes of diabetes. Approximately 80% of lower - limb amputations are caused by diabetic foot ulcers, which are the main causes of disability and death among patients. Moreover, it places a huge burden on the medical insurance system. Currently, there are western medicine treatment guidelines for diabetic foot, yet the clinical efficacy is less than satisfactory. The amputation rate caused by diabetic foot ulcers continues to rise every year. There is an urgent clinical need for novel and effective intervention measures to address this disease.\n\nMacrophages are important cells involved in the inflammatory and proliferative phases of wounds, playing a crucial role in wound repair and reconstruction. Diabetes can cause wounds to remain in the pro - inflammatory stage continuously, leading to the aggregation of M1 macrophages and preventing their timely transformation into the pro - proliferative and repair stage. As a result, wounds exhibit persistent chronic inflammation and delayed tissue proliferation or remodeling.\n\nXianglei Tangzu Ointment is a natural medicine approved for marketing by the National Medical Products Administration in November 2023. Its ingredients include Pogostemon cablin extract and asiaticoside. Research shows that the plant components in Xianglei Tangzu Ointment can promote the transformation of M1 macrophages into M2 macrophages, thereby reducing the inflammatory response and accelerating the proliferative repair of diabetic wounds. It has achieved certain curative effects in the clinical treatment of promoting wound healing. In order to use Xianglei Tangzu Ointment more precisely, accumulate clinical evidence - based medicine evidence, and explore the effectiveness and safety of Xianglei Tangzu Ointment in treating diabetic ulcers under the guidance of the chronic wound staging theory, clinical evidence - based medicine evidence needs to be obtained.",[118,27,91],"Diabetic Wound","2026-02-26",{"date":121,"type":39},"2026-03-02",{"date":123,"type":39},"2025-04-10",{"date":125,"type":20},"2027-02-15",{"name":127,"class":46},"Peking University Third Hospital",{"id":129,"slug":130,"hasResults":11,"nctId":131,"briefTitle":132,"officialTitle":133,"acronym":134,"eligibilityCriteria":135,"healthyVolunteers":136,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":137,"targetDuration":4,"studyType":21,"phases":139,"briefSummary":140,"conditions":141,"keywords":144,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":149,"lastUpdatePostDateStruct":150,"startDateStruct":152,"completionDateStruct":154,"leadSponsor":156,"locationsCount":158},"100472378","absorbable-versus-non-absorbable-sutures-for-wound-closure-in-carpal-tunnel-release-100472378","NCT05431101","abSorbable vErsus Non-absorbable SuturEs for Wound Closure in Carpal Tunnel Release","Absorbable Versus Non-absorbable Sutures for Wound Closure in Carpal Tunnel Release: a Randomized Controlled Trial","SENSE","Inclusion Criteria:\n\n• indication for carpal tunnel release\n\nExclusion Criteria:\n\n* carpal tunnel syndrome which has yet been operated\n* injection with corticosteroids",true,{"count":138,"type":20},2604,[57],"Carpal Tunnel Syndrome is a prevalent condition, up to 9% in women and 0.6% in men. Surgical decompression in the most effective treatment. After surgery, approximately 1,8% of the patients develop a wound infection. Possibly, the type of sutures used can influence the prevalence of wound infection. In this RCT the incidence of infection is investigated between the use of absorbable versus non-absorbable sutures in carpal tunnel release.",[142,27,143],"Carpal Tunnel Syndrome","Suture, Complication",[145,146,147,148],"carpal tunnel syndrome","wound infection","absorbable sutures","non-absorbable sutures","2025-08-19",{"date":151,"type":39},"2025-08-26",{"date":153,"type":39},"2022-05-01",{"date":155,"type":20},"2028-04-01",{"name":157,"class":46},"Gelre Hospitals",2,{"id":160,"slug":161,"hasResults":11,"nctId":162,"briefTitle":163,"officialTitle":164,"acronym":4,"eligibilityCriteria":165,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":166,"enrollmentInfo":167,"targetDuration":4,"studyType":21,"phases":169,"briefSummary":172,"conditions":173,"keywords":4,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":180,"lastUpdatePostDateStruct":181,"startDateStruct":183,"completionDateStruct":185,"leadSponsor":187,"locationsCount":47},"100515275","phase-2-outcomes-of-high-volume-saline-irrigation-vs-povidone-iodine-solution-cleaning-of-iowi-in-preventing-ssis-in-emergency-laparotomies-100515275","NCT05989386","Outcomes of High-volume Saline Irrigation VS Povidone-Iodine Solution Cleaning of IOWI in Preventing SSIs in Emergency Laparotomies","Outcomes of High-volume Saline Irrigation VS Povidone-Iodine Solution Cleaning of Intraoperative Incision Wound in Preventing Surgical Site Infections in Emergency Laparotomies: A Randomized Controlled Trial","Inclusion Criteria:\n\n* • Patients undergoing emergency laparotomy under the care of surgical-6 unit of Dr. Ruth K. M. Pfau Civil Hospital Karachi\n\n  * The age of patients should be between 18-60 years old.\n\nExclusion Criteria:\n\n* Diabetic patients\n* Immune-suppressed patients\n* Patients taking steroids\n* Patients undergoing chemo-radiotherapy.\n* Pregnant females\n* Previous abdominal surgery within the last 30 days.\n* Presence of concurrent abdominal wall infections.\n* Trauma Laparotomies\n* Large Bowel perforations","60 Years",{"count":168,"type":20},200,[170,171],"PHASE2","PHASE3","The goal of this clinical trial is to compare the outcomes of High-volume saline irrigation vs Povidone-iodine solution cleaning of the intraoperative incision wound in preventing superficial surgical site infections in patients undergoing emergency laparotomies. The main question it aims to answer are:\n\n* Incidence of SSI after intervention\n* Length of hospital stay\n\nParticipants will be randomly assigned to two groups receiving either of the two groups:\n\nGroup A: 1000ml of IOWI with saline solution prior to incision closure Group B: The incisional wound will be closed conventionally without irrigation.\n\nResearchers will compare groups A( experimental group) and B (control group) to compare the incidence of superficial surgical site infections after intervention.",[61,174,175,176,177,178,27,179],"Surgical Wound","Surgical Incision","Emergency Laparotomies","Laparotomies","Post Operative Wound Infection","Seroma","2025-06-14",{"date":182,"type":39},"2025-06-18",{"date":184,"type":39},"2023-04-29",{"date":186,"type":20},"2025-12-29",{"name":188,"class":46},"Dow University of Health Sciences",{"id":190,"slug":191,"hasResults":11,"nctId":192,"briefTitle":193,"officialTitle":194,"acronym":195,"eligibilityCriteria":196,"healthyVolunteers":11,"sex":16,"minAge":197,"maxAge":198,"enrollmentInfo":199,"targetDuration":4,"studyType":21,"phases":201,"briefSummary":202,"conditions":203,"keywords":4,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":214,"lastUpdatePostDateStruct":215,"startDateStruct":217,"completionDateStruct":219,"leadSponsor":221,"locationsCount":223},"100382220","phase-3-perioperative-respiratory-care-and-outcomes-for-patients-undergoing-high-risk-abdominal-surgery-100382220","NCT04256798","Perioperative Respiratory Care and Outcomes for Patients Undergoing High Risk Abdominal Surgery","PErioperative Respiratory Care and Outcomes for patieNts Undergoing hIgh Risk abdomiNal Surgery: A 2x2 Factorial, International Pragmatic Randomised Controlled Trial Across Low and Middle-income Countries","PENGUIN","Inclusion Criteria:\n\n* Adults and children aged 10 years or over\n* Elective or emergency abdominal surgery via midline laparotomy with an anticipated abdominal incision of at least 5cm in length\n* Written informed consent of patient (signature or a fingerprint)\n\nExclusion Criteria:\n\n* Patients undergoing caesarean section\n* Patients with a documented or suspected allergy to chlorhexidine\n* Patient unable to complete postoperative follow-up (not contactable after discharge)\n* Previous enrolment in PENGUIN within the past 30 days\n* American Society of Anesthesiologists (ASA) grade V patients (expected to die with or without surgery)","10 Years","100 Years",{"count":200,"type":20},12942,[171],"PENGUIN is a pragmatic multi-center trial investigating the effects of pre-operative mouthwash and perioperative oxygen on the incidences of pneumonia and surgical site infection (SSI) following major abdominal surgery.\n\nPatients will be recruited from low and middle income countries and randomly assigned to a trial treatment arms: a) pre-operative chlorhexidine mouthwash and 80-100% FiO2; b) no pre-operative mouthwash and 80-100% fraction of inspired oxygen (FiO2); c) pre-operative chlorhexidine mouthwash and 21- 30% FiO2; or d) no pre-operative mouthwash and 21-30% FiO2.",[204,205,61,27,206,207,208,209,210,211,212,213],"Infection","Pneumonia","Surgical Wound Infection","Postoperative Complications","Anesthesia","Communicable Disease","Pathologic Processes","Perioperative Complication","Chlorhexidine","Laparotomy","2025-02-18",{"date":216,"type":39},"2025-02-19",{"date":218,"type":39},"2020-11-13",{"date":220,"type":20},"2026-06-01",{"name":222,"class":46},"University of Birmingham",37,{"id":225,"slug":226,"hasResults":11,"nctId":227,"briefTitle":228,"officialTitle":228,"acronym":229,"eligibilityCriteria":230,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":231,"enrollmentInfo":232,"targetDuration":4,"studyType":234,"phases":4,"briefSummary":235,"conditions":236,"keywords":241,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":243,"lastUpdatePostDateStruct":244,"startDateStruct":246,"completionDateStruct":248,"leadSponsor":250,"locationsCount":47},"100574372","hierarchy-of-effects-of-laboratory-markers-and-their-interaction-with-comorbidity-concerning-outcome-and-personalized-treatment-of-trauma-patients-in-emergency-care-and-rehabilitation-100574372","NCT06758427","Hierarchy of Effects of Laboratory Markers and Their Interaction With Comorbidity Concerning Outcome and Personalized Treatment of Trauma Patients in Emergency Care and Rehabilitation","HELICOPTER","Inclusion Criteria:\n\n* acute long bone fracture (humerus, ulna, radius, femur, tibia) with surgical treatment\n\nExclusion Criteria:\n\n* associated severe injury (ISS \\> 16)\n* associated traumatic brain injury\n* associated traumatic spine injury\n* dementia","67 Years",{"count":233,"type":20},2300,"OBSERVATIONAL","At least ten percent of trauma patients suffer from any sort of complication. The study aims to identify a risk factor profile to early identify trauma patients at risk.",[207,61,27,237,238,239,205,240],"Non-healing Wound","Pseudarthrosis","Bone Infection","Nosocomial Infection",[242],"long bone fracture, trauma","2024-12-27",{"date":245,"type":39},"2025-01-03",{"date":247,"type":20},"2025-02-01",{"date":249,"type":20},"2027-10-31",{"name":251,"class":46},"Department of Trauma and Reconstructive Surgery at Eberhard Karls University Tuebingen, BG Klinik Tu",{"id":253,"slug":254,"hasResults":11,"nctId":255,"briefTitle":256,"officialTitle":257,"acronym":4,"eligibilityCriteria":258,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":112,"enrollmentInfo":259,"targetDuration":4,"studyType":21,"phases":260,"briefSummary":261,"conditions":262,"keywords":265,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":268,"lastUpdatePostDateStruct":269,"startDateStruct":271,"completionDateStruct":273,"leadSponsor":275,"locationsCount":47},"100552675","validation-of-hematological-indices-100552675","NCT06476171","Validation of Hematological Indices","Validation of Hematological Indices as Prognostic Markers of Inflammatory Complications and Multiple Organ Dysfunction in Cardiac Surgery Patients.","Inclusion Criteria:\n\n* age from 18 to 80 years\n* cardiac surgery\n* operation in the conditions of cardiopulmonary bypass\n* availability of voluntary informed consent of the patient to participate in the study\n\nExclusion Criteria:\n\n* refusal of the patient from the study\n* transfer of the patient to another medical institution",{"count":168,"type":20},[57],"The hypothesis of the study is that hematological indices (neutrophil to lymphocyte ratio, platelet to lymphocyte ratio and systemic index of inflammation) may be predictors of infectious complications and multiple organ dysfunction in patients after cardiac surgery.",[263,264,205,27],"Multiple Organ Dysfunction","Sepsis",[263,264,266,267],"cardiac surgery","hematological indices","2024-11-20",{"date":270,"type":39},"2024-11-25",{"date":272,"type":39},"2023-06-19",{"date":274,"type":20},"2025-12-30",{"name":276,"class":46},"Petrovsky National Research Centre of Surgery",{"id":278,"slug":279,"hasResults":11,"nctId":280,"briefTitle":281,"officialTitle":282,"acronym":283,"eligibilityCriteria":284,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":285,"targetDuration":4,"studyType":21,"phases":287,"briefSummary":288,"conditions":289,"keywords":292,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":300,"lastUpdatePostDateStruct":301,"startDateStruct":303,"completionDateStruct":305,"leadSponsor":307,"locationsCount":309},"100514386","propel-2-prophylactic-negative-pressure-wound-therapy-in-laparotomy-wounds-100514386","NCT05977816","PROPEL-2: Prophylactic Negative Pressure Wound Therapy in Laparotomy Wounds","PROPEL-2 Prophylactic Negative Pressure Wound Therapy (NPWT) in Laparotomy Wounds: a Randomised Controlled Trial Comparing Negative Pressure Wound Therapy to Standard Wound Management in Patients Following Midline Laparotomy","PROPEL-2","Inclusion Criteria:\n\n* Aged 18 years or older\n* Patient requires visceral abdominal surgery via a midline laparotomy\n* Patients who can complete questionnaires\n\nExclusion Criteria:\n\n• Patients who are unable to adhere to protocol requirements",{"count":286,"type":20},2000,[57],"Post-operative wound issues in abdominal surgery have a significant impact on patient outcomes. This study is taking place to investigate if Negative Pressure Wound Therapy (NPWT) dressings reduces Surgical Site Infections, post surgical complications and improves scar appearance compared to standard dressings.",[290,27,291],"Wound Surgical","Cosmesis",[293,294,213,295,296,297,298,299],"Negative Pressure Wound Therapy","Surgical site Infection","Post-operative Complications","Abdominal Incision","health economics","POSAS","CoPaQ","2024-10-24",{"date":302,"type":39},"2024-10-26",{"date":304,"type":39},"2023-07-14",{"date":306,"type":20},"2026-07",{"name":308,"class":46},"Royal College of Surgeons, Ireland",11,{"id":311,"slug":312,"hasResults":11,"nctId":313,"briefTitle":314,"officialTitle":315,"acronym":316,"eligibilityCriteria":317,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":318,"targetDuration":4,"studyType":21,"phases":320,"briefSummary":288,"conditions":321,"keywords":322,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":325,"lastUpdatePostDateStruct":326,"startDateStruct":328,"completionDateStruct":330,"leadSponsor":332,"locationsCount":333},"100518031","pinta---prophylactic-incisional-negative-pressure-therapy-for-major-amputations-100518031","NCT06025253","PINTA - Prophylactic Incisional Negative Pressure Therapy for Major Amputations","Prophylactic Single-Use Negative Pressure Wound Therapy Devices for Closed Incision Major Amputations","PINTA","Inclusion Criteria:\n\n* Patients aged 18 years or older;\n* Patients undergoing major lower extremity amputation, including below-knee amputation, through-knee amputation and above-knee amputation, for any indication;\n* Patients with primary closure of the surgical incision using either interrupted or continuous sutures\n\nExclusion Criteria:\n\n* Patients \\\u003C18 years;\n* Women who are pregnant and\u002For breast-feeding;\n* Patients with amputations performed without primary skin closure, including guillotine amputations, amputations deliberately left open for drainage purposes and amputations with soft tissues defects at the stump;\n* Patients with amputations where skin glue is the only means of skin closure\n* Patients with a clinically absent femoral pulse",{"count":319,"type":20},728,[57],[290,27,291],[293,61,295,323,299,324],"Health Economics","WoundQol","2024-10-16",{"date":327,"type":39},"2024-10-18",{"date":329,"type":39},"2024-03-01",{"date":331,"type":20},"2026-12-20",{"name":308,"class":46},7,{"id":335,"slug":336,"hasResults":11,"nctId":337,"briefTitle":338,"officialTitle":339,"acronym":340,"eligibilityCriteria":341,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":342,"targetDuration":4,"studyType":21,"phases":344,"briefSummary":345,"conditions":346,"keywords":349,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":354,"lastUpdatePostDateStruct":355,"startDateStruct":357,"completionDateStruct":359,"leadSponsor":361,"locationsCount":47},"100532994","comparing-pp-and-pvdf-meshes-in-midline-laparotomy-closure-for-high-risk-colorectal-surgery-impact-on-incisional-hernia-and-surgical-wound-infection-100532994","NCT06220045","Comparing PP and PVDF Meshes in Midline Laparotomy Closure for High-risk Colorectal Surgery. Impact on Incisional Hernia and Surgical Wound Infection.","Comparison Between the Use of a Polypropylene (PP) Prophylactic Mesh and a Polyvinylidene Fluoride (PVDF) Mesh in the Closure of Midline Laparotomy in Emergency Colorectal Surgery for High-risk Patients of Incisional Hernia. Impact on Surgical Wound Infection.","PROFIMESH","Inclusion Criteria:\n\n* Patients diagnosed with colorectal pathology requiring urgent surgical treatment via midline laparotomy.\n* Patients undergoing urgent laparoscopic surgery but requiring conversion to midline laparotomy.\n* Need for urgent surgical treatment involving the colon and\u002For rectum, even in the presence of other abdominal pathologies.\n* Age over 18 years.\n* Signed informed consent (IC) from both the patient and the investigator\n* Severe chronic obstructive pulmonary disease (COPD) according to the GOLD classification or decompensated COPD.\n* BMI ≥ 35 kg\u002Fm2.\n* Re-laparotomies.\n\nExclusion Criteria:\n\n* Patients with psychiatric illnesses, addictions, or any disorder hindering the understanding of the Informed Consent.\n* Inability to read or comprehend any of the languages in the Informed Consent (Catalan, Spanish).",{"count":343,"type":20},60,[57],"In the latest guidelines for abdominal wall closure in emergency surgery published in the World Journal of Emergency Surgery (WJES) in 2023, no specific recommendations are made in this regard.\n\nCurrent literature does not provide any articles comparing these two types of mesh materials (PP vs PVDF) in emergency colorectal surgery. It is necessary to conduct a study comparing these two types of mesh materials, specifically in high-risk patients for incisional hernia and emergency colorectal surgery. This study aims to contribute to generating evidence regarding differences in wound infection incidence and potential subsequent complications, such as chronic pain.\n\nIt is essential to conduct a study comparing different methods of laparotomy closure, specifically in emergency colorectal surgery, to contribute valuable evidence regarding the incidence of incisional hernia and potential subsequent complications.",[347,27,348],"Colorectal Cancer","Hernia Incisional",[350,27,348,351,352,353],"Colorectal cancer","Mesh","Polypropylene","PVDF","2024-10-06",{"date":356,"type":39},"2024-10-08",{"date":358,"type":39},"2024-02-01",{"date":360,"type":20},"2025-01-15",{"name":362,"class":46},"Institut d'Investigació Biomèdica de Girona Dr. Josep Trueta",{"id":364,"slug":365,"hasResults":11,"nctId":366,"briefTitle":367,"officialTitle":368,"acronym":369,"eligibilityCriteria":370,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":371,"targetDuration":4,"studyType":21,"phases":373,"briefSummary":374,"conditions":375,"keywords":377,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":354,"lastUpdatePostDateStruct":381,"startDateStruct":382,"completionDateStruct":384,"leadSponsor":386,"locationsCount":47},"100532995","comparing-polypropylene-mesh-and-small-bites-technique-in-emergency-colorectal-surgerys-midline-laparotomy-closure-study-for-incisional-hernia-prevention-100532995","NCT06220058","Comparing Polypropylene Mesh and \"Small Bites\" Technique in Emergency Colorectal Surgery's Midline Laparotomy Closure. Study for Incisional Hernia Prevention.","Comparison Between the Use of a Prophylactic Polypropylene Mesh and the \"Small Bites\" Technique in Midline Laparotomy Closure for Emergency Colorectal Surgery for Incisional Hernia Prevention","BITEME","Inclusion Criteria:\n\n* Patients diagnosed with colorectal pathology requiring urgent surgical treatment via midline laparotomy.\n* Patients undergoing urgent laparoscopic surgery but necessitating conversion to midline laparotomy.\n* Urgent surgical intervention required at the level of the colon and\u002For rectum, even in the presence of other abdominal pathologies.\n* Age over 18 years.\n* Signed informed consent (IC) from the patient and the investigator.\n\nExclusion Criteria:\n\n* Severe chronic obstructive pulmonary disease (COPD) according to the GOLD classification or decompensated COPD.\n* BMI ≥ 35 kg\u002Fm2.\n* Re-laparotomies.\n* Patients with psychiatric illnesses, addictions, or any disorder hindering the understanding of the Informed Consent.\n* Inability to read or comprehend any of the languages in the Informed Consent (Catalan, Spanish).",{"count":372,"type":20},148,[57],"The 2023 World Journal of Emergency Surgery guidelines couldn't provide a recommendation for emergency abdominal wall closure due to insufficient consensus (\\>80% required). Available evidence, predominantly retrospective and heterogeneous, lacks differentiation between urgent and elective colorectal surgeries. Therefore, we advocate for a study comparing laparotomy closures in emergency colorectal surgery to contribute evidence on incisional hernia incidence and subsequent complications.",[347,376,27],"Incisional Hernia",[378,348,379,380],"colorectal cancer","Wound infection","small bites",{"date":356,"type":39},{"date":383,"type":39},"2024-02-05",{"date":385,"type":20},"2027-01-15",{"name":387,"class":46},"Fernandez Zamora",{"id":389,"slug":390,"hasResults":11,"nctId":391,"briefTitle":392,"officialTitle":393,"acronym":394,"eligibilityCriteria":395,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":396,"targetDuration":4,"studyType":21,"phases":398,"briefSummary":400,"conditions":401,"keywords":408,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":414,"lastUpdatePostDateStruct":415,"startDateStruct":417,"completionDateStruct":419,"leadSponsor":421,"locationsCount":47},"100554892","phase-4-powdered-intrawound-vancomycin-in-open-fractures-trial-100554892","NCT06504992","Powdered Intrawound Vancomycin in Open Fractures Trial","Powdered Intrawound Vancomycin in Open Fractures: a Randomized Controlled Trial","PIVOT","Inclusion Criteria:\n\n* 18 years or older at time of surgery\n* Patients with an open fracture classified as Gustilo Type I to IIIc in the clavicle, humerus, radius, ulna, metacarpals, upper extremity phalanges (fingers), femur, tibia, fibula and metatarsals and lower extremity phalanges (toes).\n* Open fracture treated operatively with plate(s) and screw(s) hardware fixation and intramedullary fixation (IM nail).\n* Able to attend standard of care follow up for six months post-operatively\n\nExclusion Criteria:\n\n* Patients with known vancomycin allergy, drug administration reaction, or other sensitivities to vancomycin.\n* Patients who have already had definitive fracture fixation before enrollment in the study\n* Patients with open fracture already infected at time of enrollment\n* Patients with current positive blood cultures (bacteremia) at time of enrollment (current, meaning they have not received treatment and now have negative most-recent blood cultures).\n* Patients who have other forms of local antibiotics that are left in place at the end of the definitive fixation surgery (e.g., antibiotic loaded cement or polymethyl methacrylate (PMMA) beads)\n* Patients who do not speak English\n* Patients who are currently pregnant\n* Patients who are unable to provide consent and do not have a substitute decision maker able to provide consent\n* Patients who will have severe difficulty with follow up",{"count":397,"type":20},350,[399],"PHASE4","The purpose of this randomized control trial is to compare the rate of post-operative infection in patients with open fractures in upper or lower extremity long bones randomized to receive intra-operative intrawound topical vancomycin powder on their open fractures in addition to the current best practice of intravenous antibiotics with irrigation and debridement compared to intravenous antibiotics with irrigation and debridement alone during definitive operative fixation of the fracture.",[402,403,404,405,27,406,407],"Open Fracture","Trauma","Infection, Surgical Site","Fractures, Open","Fractures, Bone","Post-Operative Wound Infection",[409,410,411,412,413],"open fracture","vancomycin","infection","trauma","intrawound","2024-09-17",{"date":416,"type":39},"2024-09-19",{"date":418,"type":20},"2024-11-01",{"date":420,"type":20},"2029-09-01",{"name":422,"class":46},"University of Manitoba",{"id":424,"slug":425,"hasResults":11,"nctId":426,"briefTitle":427,"officialTitle":428,"acronym":4,"eligibilityCriteria":429,"healthyVolunteers":136,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":430,"targetDuration":4,"studyType":21,"phases":431,"briefSummary":432,"conditions":433,"keywords":436,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":441,"lastUpdatePostDateStruct":442,"startDateStruct":444,"completionDateStruct":446,"leadSponsor":448,"locationsCount":47},"100560362","phase-3-the-role-of-antibiotic-prophylaxis-in-lowering-wound-infection-rates-post-open-repair-of-primary-elective-groin-hernias-in-high-risk-patients-100560362","NCT06576154","The Role of Antibiotic Prophylaxis in Lowering Wound Infection Rates Post-Open Repair of Primary Elective Groin Hernias in High-Risk Patients","The Role of Antibiotic Prophylaxis in Lowering Wound Infection Rates Post-Open Repair of Primary Elective Groin Hernias in High-Risk Patients: A Randomized Control Trial.","Inclusion Criteria:\n\n* Volunteer to participate in the study.\n* Elderly patients aged over 60 years.\n* Patients with Diabetes.\n* Or obese patients with a BMI greater than 35.\n* Or immunocompromised patients.\n* Or American Society of Anesthesiologists (ASA) physical status classification 2 or more, with a history of more than 10 years.\n\nExclusion Criteria:\n\n* Non-cooperative patients for regular follow-up.\n* Therapeutic Indication for.",{"count":168,"type":20},[171],"This study aims to investigate the impact of antibiotic prophylaxis on reducing wound infection rates following open repair of primary elective groin hernias in high-risk patients.",[434,27,435],"Antibiotic Prophylaxis","Groin Hernia",[437,438,379,439,440],"Groin hernia","Postoperative complications","Surgical site infection","High-risk patients","2024-08-27",{"date":443,"type":39},"2024-08-28",{"date":445,"type":39},"2024-08-01",{"date":447,"type":20},"2025-09-01",{"name":449,"class":46},"University of Aleppo",{"id":451,"slug":452,"hasResults":11,"nctId":453,"briefTitle":454,"officialTitle":455,"acronym":4,"eligibilityCriteria":456,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":457,"targetDuration":4,"studyType":21,"phases":458,"briefSummary":459,"conditions":460,"keywords":462,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":466,"lastUpdatePostDateStruct":467,"startDateStruct":469,"completionDateStruct":471,"leadSponsor":473,"locationsCount":47},"100559039","incisional-negative-pressure-therapy-to-prevent-animal-induced-wound-infection-100559039","NCT06558942","Incisional Negative Pressure Therapy to Prevent Animal Induced Wound Infection","A Study on the Application of Incisional Negative Pressure Therapy in Reducing the Risk of Infection in Animal Induced Injury Patients With Primary Wound Closure","Inclusion Criteria:\n\n* Limds injuries caused by animals, first or second animal injury to Grade III exposed patients, with deep wounds reaching the fat layer, tendons, and even penetrating injuries.\n* Patients with wounds\\>2cm and severe injuries that even require surgical treatment.\n\nExclusion Criteria:\n\n* Missing or incomplete follow-up data within 30 days.\n* Patients who have been infected with wounds or have been injured for more than 8 hours before seeking medical attention.\n* Acupuncture like wound (\\\u003C2mm).\n* Patients with whole skin detachment.",{"count":343,"type":20},[57],"Animal injuries are a significant public health issue, with the most common being bites or scratches from cats and dogs. Every year, over 40 million people in China are bitten or scratched by cats and dogs, which can lead to wound infections and even systemic complications, with infection rates ranging from 10% to 80%. However, there is still no better way to reduce wound infection rates in current clinical studies and guidelines.\n\nIncisional negative pressure wound therapy (iNPWT) is a new wound treatment technology developed in recent years. It creates a negative pressure environment on sutured or closed wounds, helps to fix the edges of the incision together, reduce lateral tension on the wound, stimulate blood perfusion at the edge of the wound, remove fluid from the wound, and act as an external pollution barrier. INPWT has been widely used for postoperative wound healing in surgery, but there is currently a lack of effective clinical trials on its ability to prevent wound infections caused by animal injuries and promote wound healing.\n\nThis study aims to apply iNPWT technology to the wounds of patients with rabies grade III exposure who underwent primary suturing, and compare it with wounds covered with ordinary gauze after previous primary suturing to determine whether it can help reduce postoperative incision infection rates and promote wound healing. This will provide high-quality clinical evidence for the widespread use of wound management in rabies grade III exposure patients in the future.",[461,27],"Injury Caused by Animal Bites",[463,464,465],"Animal bite injury","Incision negative pressure treatment technology","Wound infection rate","2024-08-15",{"date":468,"type":39},"2024-08-19",{"date":470,"type":20},"2024-08-20",{"date":472,"type":20},"2026-04-30",{"name":474,"class":46},"Peking University First Hospital"]