[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"young-onset-dementia\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:young-onset-dementia":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,44,78],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100594383","addressing-emotional-distress-in-dyads-of-persons-with-a-young-onset-dementia-yod-and-their-care-partners-100594383",false,"NCT07018726","Addressing Emotional Distress in Dyads of Persons With a Young Onset Dementia (YOD) and Their Care-partners","Inclusion Criteria:\n\n* Between the ages of 18-65 at the time of enrollment \\[both patient and care-partner\\]\n* Diagnosis of young-onset dementia (FTD, PPA, AD, PCA, etc.) with symptom onset prior to age 65 \\[patient\\]\n* A designated care-partner willing and interested to participate \\[both patient and care-partner\\]\n* Received YOD diagnosis in the past 6 month \\[patient\\]\n* English fluency and literacy \\[both patient and care-partner\\]\n* Cognitive ability to understand study and research protocol in order to consent to study participation per referring neurologist \\[both patient and care-partner\\]\n* Patient and\u002For caregiver exhibit emotional distress on screening (using HADS D and\u002For HADS A scores \\> 7)\n\nExclusion Criteria:\n\n* An additional, terminal diagnosis such as cancer\n* Lack of access to internet and\u002For a device with a camera\n* Current untreated or unstable severe mental health conditions like bipolar disorder, schizophrenia, or active substance use","ALL","18 Years","65 Years",{"count":19,"type":20},388,"ESTIMATED","INTERVENTIONAL",[23],"NA","The purpose of the present investigation is to test the efficacy of a virtual, brief (6 sessions) dyadic (patient and care-partner together) intervention to prevent chronic emotional distress in dyads where one person is diagnosed with Young Onset Dementia (YOD). Through this study, we seek to address the unmet need of preventing chronic emotional distress in YOD dyads through a feasible, acceptable and credible program, and ideally enhance resiliency and improve wellbeing and quality of life in both members of the dyad.",[26],"Young Onset Dementia",[28,29,26,30],"Emotional Distress","Dyadic Intervention","Caregiving","RECRUITING","2026-04-10",{"date":34,"type":35},"2026-04-15","ACTUAL",{"date":37,"type":35},"2026-01-28",{"date":39,"type":20},"2031-01-01",{"name":41,"class":42},"Massachusetts General Hospital","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":48,"acronym":49,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":51,"targetDuration":4,"studyType":53,"phases":4,"briefSummary":54,"conditions":55,"keywords":62,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":43},"100611017","omics-sciences-for-the-identification-of-pathogenetic-mechanisms-and-biomarkers-in-neurodegenerative-diseases-100611017","NCT07235111","Omics Sciences for the Identification of Pathogenetic Mechanisms and Biomarkers in Neurodegenerative Diseases","NeurOmics","Inclusion Criteria\n\n• Patients suffering from neurodegenerative diseases\n\nExclusion Criteria\n\n• Patients not suffering from neurodegenerative diseases",{"count":52,"type":20},1200,"OBSERVATIONAL","The study aims to use 'omics' sciences, employing the most advanced technologies currently available, in order to identify pathogenic genomic variants, proteins and\u002For altered molecular pathways in neurodegenerative diseases and to obtain a new and more complete characterisation of subjects affected by the neurodegenerative diseases under study. Thanks to the integration of genomic, gene expression (transcriptomic and epigenomic), protein and metabolic data and clinical data, the study also aims to identify new markers for the diagnosis, prognosis, also in terms of response to therapy, and monitoring of neurodegenerative diseases.\n\nThe study involves the enrolment of at least 1.200 individuals with neurodegenerative disease.",[56,57,58,59,60,61],"Alzheimer Disease","FTD","Young-onset Dementia","MCI","Parkinson Disease","ALS (Amyotrophic Lateral Sclerosis)",[63,64,65,66,67,68],"LEWY BODIES DISEASE","young-onset dementia","alzheimer","parkinson","als","mci","2025-11-20",{"date":71,"type":35},"2025-11-25",{"date":73,"type":35},"2025-02-28",{"date":75,"type":20},"2039-09-17",{"name":77,"class":42},"Ospedale Policlinico San Martino",{"id":79,"slug":80,"hasResults":11,"nctId":81,"briefTitle":82,"officialTitle":83,"acronym":84,"eligibilityCriteria":85,"healthyVolunteers":86,"sex":15,"minAge":16,"maxAge":87,"enrollmentInfo":88,"targetDuration":4,"studyType":53,"phases":4,"briefSummary":90,"conditions":91,"keywords":4,"overallStatus":92,"whyStopped":4,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":4},"100538089","yod-risoco-social-cognition-and-risk-taking-behaviour-in-patients-with-young-onset-dementia-100538089","NCT06286293","YOD-RiSoCo: Social Cognition and Risk-taking Behaviour in Patients with Young-onset Dementia","YOD-RiSoCo: the Role of Social Cognition and Better Identification of Risk-taking Behaviour in Patients with Young-onset Dementia","YOD-RiSoCo","Inclusion Criteria:\n\nAll subjects\n\n* Sufficient command of the Dutch language\n* In possession of a driver's license with any driving experience throughout life\n* Age 18 to 65\n\nbvYOD subjects\n\n* Probable diagnosis of young-onset dementia (before 65 years old), confirmed after interdisciplinary consensus meeting in which interviews, neuropsychological examination, neurological and psychiatric assessments, neuro-imaging, blood samples, and in some cases FDG\u002FPIB-PETscans, CSF biomarkers or genetic counseling were discussed.\n* Nosological diagnosis of bvFTD or bvAD\n\nNon-bvYOD subjects\n\n* Probable diagnosis of young-onset dementia (before 65 years old), confirmed after interdisciplinary consensus meeting in which interviews, neuropsychological examination, neurological and psychiatric assessments, neuro-imaging, blood samples, and in some cases FDG\u002FPIB-PETscans, CSF biomarkers or genetic counseling were discussed.\n* YOD subtypes other dan bvFTD or bvAD, such as amnestic variant AD.\n\nFrontal brain injury subjects\n\n\\- Neurological patients with frontal brain injury (e.g. traumatic brain injury, stroke or brain tumor patients).\n\nExclusion Criteria:\n\nAll subjects\n\n* Suffering from severe motion sickness; motion sickness is a risk factor for simulator sickness\n\nYOD subjects:\n\n\\- Presence of premorbid severe neurological or psychiatric pathology, non-related to dementia.\n\nFrontal brain injury subjects:\n\n\\- Presence of serious psychiatric disorders or other neurological comorbidities.\n\nHealthy control subjects:\n\n* Presence of serious psychiatric disorders\n* History of neurological disorders, which may interfere with cognitive functioning (e.g. recent concussion, previous subarachnoid or intracerebral haemorrhage, intracranial tumours, epilepsy, ischemic stroke).",true,"70 Years",{"count":89,"type":20},140,"The goal of this observational study is to learn about social cognition and risky behaviour in patients with young-onset dementia (YOD). The investigators want to\n\n* Examine differences in performance on social cognition test and measures of risky behaviour between behavioural variant YOD patients, patients with frontal brain injury, non-behavioural YOD patients and healthy controls.\n* Examine if there is a relation between social cognition tests and measures of risky behaviour.\n\nParticipants will be administered a neuropsychological assessment including social cognition measures and patients will complete a driving simulator task in which risky behaviour will be elicited.",[58],"NOT_YET_RECRUITING","2025-01-08",{"date":95,"type":35},"2025-01-10",{"date":97,"type":20},"2025-02-04",{"date":99,"type":20},"2027-03-31",{"name":101,"class":42},"University Medical Center Groningen"]