[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"young-people\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:young-people":31},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,50],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":25,"conditions":26,"keywords":32,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":4},"100576855","paediatric-breakthrough-pain-assessment-100576855",false,"NCT06790719","Paediatric Breakthrough Pain Assessment","Development and Validation of a Paediatric Breakthrough Pain Assessment Tool","BEACON","Inclusion Criteria:\n\n* Children and young people aged 8-25 years who have experienced 1) background pain related to a life limiting or life threatening condition and 2) around-the-clock analgesia prescribed for the previous week, as confirmed by their healthcare team (Studies 1, 2, and 3).\n* Children and young people must be able to communicate and read in English at a level close to, or in line with their chronological age.\n* For study 1, non-verbal children and young people, or those with limited verbal ability, will be recruited if they are happy to participate using the Microsoft Teams chat function.\n* Parents and caregivers of children and young people aged 3-month-25-years who have experienced 1) background pain related to a life limiting or life threatening condition and 2) around-the-clock analgesia prescribed for the previous week, as confirmed by their healthcare team. (Studies 1, 2, and 3).\n* Caregivers can be caring for verbal, non-verbal, or pre-verbal children with or without cognitive or developmental difficulties of any level.\n* Parents and caregivers must have self-reported full or partial responsibility for assessing the child or young person's pain.\n* Healthcare professionals in primary, secondary and tertiary care who are involved in the care of children and young people with life limiting or life threatening conditions (Studies 2 and 3).\n\nExclusion Criteria:\n\n* • Children, young people, parents and caregivers with limited ability to communicate and read in English.\n\n  * Children and young people judged by caregivers or healthcare professionals to lack capacity to take part, who are too unwell, or might find it too distressing.\n  * Parents and caregivers judged by healthcare professionals to lack capacity to consent, or to be 'struggling' too much. However, if they wish to take part, they can send an email or text message to the study email account or mobile phone.",true,"ALL","8 Years","99 Years",{"count":22,"type":23},210,"ESTIMATED","OBSERVATIONAL","Many children and young people with life-limiting and life-threatening illnesses get sudden bursts of pain called breakthrough pain. At the moment, there aren't any good ways to measure this pain in children and young people. The investigators are developing two questionnaires to help: one for patients to fill out themselves and another for parents or healthcare professionals to complete for younger children and young people who cannot explain their pain for themselves.\n\nThe investigators plan to work with 210 people across hospitals and hospices in England and Wales. This includes children and young people with life-limiting and life-threatening illnesses, their caregivers, and healthcare professionals. The investigators have already made a first version of the questionnaires.\n\nThe project has three main Studies:\n\nIn Study 1, the investigators will talk to 5-10 young patients and 5-10 caregivers about their experiences with breakthrough pain. The investigators will use their feedback to improve the questionnaires.\n\nIn Study 2, the investigators will ask 5-10 patients, 5-10 caregivers, and 5-10 healthcare professionals to fill out the questionnaires while speaking their thoughts out loud. This will help the investigators find any parts that are confusing or difficult to understand.\n\nIn Study 3, the investigators will test how well the questionnaires works. 80 patients, 40 caregivers, and 40 healthcare professionals will complete the questionnaires three different times to make sure they measure breakthrough pain as accurately as possible.\n\nThese questionnaire will be useful for hospitals and hospices across England and Wales to help them better manage pain, including breakthrough pain, in patients aged 3 months to 25 years who have life-limiting and life-threatening illnesses.",[27,28,29,30,31],"Breakthrough Pain","Palliative Medicine","Oncology Pain","Pediatric ALL","Young People",[33,34,35,36,37],"Breakthrough pain","paediatrics","paediatric pain","palliative care","pain assessment","NOT_YET_RECRUITING","2025-01-17",{"date":41,"type":42},"2025-01-24","ACTUAL",{"date":44,"type":23},"2025-01-20",{"date":46,"type":23},"2025-12",{"name":48,"class":49},"University of Southampton","OTHER",{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":4,"eligibilityCriteria":56,"healthyVolunteers":17,"sex":18,"minAge":57,"maxAge":58,"enrollmentInfo":59,"targetDuration":4,"studyType":61,"phases":62,"briefSummary":64,"conditions":65,"keywords":68,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":78,"locationsCount":81},"100538695","tdcs-interventions-for-subthreshold-depressive-symptoms-in-young-individuals-100538695","NCT06294184","TDCS Interventions for Subthreshold Depressive Symptoms in Young Individuals.","Transcranial Direct Current Stimulation Interventions for Subthreshold Depressive Symptoms in Young Individuals.","Inclusion Criteria:\n\n* 1\\) Be between the ages of 12-25;\n* 2\\) is right-handed on the Edinburgh Handedness Inventory;\n* 3\\) 2-4 of the 9 depressive symptoms defined by the American Diagnostic and Statistical Manual of Diseases, Fifth Edition (DSM-5), lasting more than 1 week; or more than 5 depressive symptoms lasting more than 1 week but less than 2 weeks (i.e., not meeting criteria for a major depressive episode) (by DSM-5 Clinical Semi-Definitive Interview (K-SADS-PL) (Gilbody et al., 2017, JAMA);\n* 4\\) Hamilton Depression Scale (HAMD-24) 24 points≥ 8 points, \\< 24 points;\n* 5\\) Gender is not limited;\n* 6\\) Subjects and their families voluntarily participate and sign the informed consent form.\n\nExclusion Criteria:\n\n* 1\\) Individuals with the following diagnoses according to DSM-5: psychiatric disorders due to organic diseases, substance-related and addictive disorders, neurodevelopmental disorders, schizophrenia spectrum and other psychotic disorders, bipolar disorder (assessed by K-SADS-PL);\n* 2\\) Have two or more DSM-V-defined manic symptoms for 4 days but do not meet the criteria for hypomania or meet the DSM-V defined criteria for hypomanic symptoms for only 2-3 days;\n* 3\\) Severe or unstable physical illness;\n* 4\\) have a moderate or higher risk of suicide (as assessed by the Columbia Suicide Severity Scale);\n* 5\\) Received transcranial direct current stimulation in the past three months (continuous intervention time: \\>2 weeks);\n* 6\\) Contraindications to transcranial direct current stimulation, such as brain implants, personal or family history of epilepsy;\n* 7\\) Magnetic resonance scanning is contraindicated, such as in vivo metal implants.","12 Years","25 Years",{"count":60,"type":23},150,"INTERVENTIONAL",[63],"NA","The purpose of this study is to assess the mechanisms of the effect of transcranial direct current stimulation (tDCS) in alleviating subthreshold depressive symptoms in young individuals, and individualized outcome prediction is carried out.",[66,31,67],"Subthreshold Depression","Transcranial Direct Current Stimulation",[69,70],"Resting-state brain functional network","Social emotion","RECRUITING","2024-12-07",{"date":74,"type":42},"2024-12-12",{"date":76,"type":42},"2023-11-01",{"date":46,"type":23},{"name":79,"class":80},"Guangzhou Psychiatric Hospital","OTHER_GOV",1]