[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"zinc-status\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:zinc-status":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,49,87],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100563160","zn-supplementation-in-hiv-immunological-non-responders-100563160",false,"NCT06612554","Zn Supplementation in HIV Immunological Non Responders","Role of Zinc Supplementation in Immunological Non-responders HIV Individuals: Exploring Pathways for Persistent Inflammation","VIHZn","Inclusion Criteria:\n\n* confirmed HIV infection;\n* 18 years or older\n* Serum zinc levels less than 150ug\u002Fdl (normal range considered 75-150 ug\u002Fdl)\n* HIV-1 infection on stable ART for at least 3 months with cumulative ART duration of at least 6 months\n* Undetectable (less than 50copies\u002Fml) persistently (isolated transient increases in viremia of less than 1000 copies\u002Fml will be accepted)\n* Persistent less than 500CD4+ T-cells\u002Fmm3 at enrolment or an increase of less than 80 cells\u002Fmm3 after one year of viral undetectability\n\nExclusion Criteria:\n\n* Pregnancy\n* Lactation\n* Active infectious or inflammatory condition\n* Uncontrolled diabetes\n* Serum Zinc levels more than 150ug\u002Fdl","ALL","18 Years",{"count":20,"type":21},120,"ESTIMATED","INTERVENTIONAL",[24],"NA","Zinc is an essential micronutrient crucial for the normal functioning of the human immune system. Zinc deficiency impairs immune function and increases infection risk, especially in vulnerable populations like people living with HIV. This project aims to study the role of zinc supplementation in improving immune response in HIV-infected individuals who are Immunological Non-Responders (INRs)-people who have not restored Cluster of differentiation 4 (CD4) T-cell counts despite receiving antiretroviral therapy (ART). INRs face a higher risk of opportunistic infections, non-HIV comorbidities due to high inflammation, and generally have a poorer prognosis. Zinc supports immune function by aiding in immune cell development, cytokine production, and maintaining mucosal barrier integrity.\n\nSeveral studies have investigated zinc supplementation in HIV-infected individuals, showing significant increases in CD4 counts and a reduction in opportunistic infections. However, the doses used vary, and the results are sometimes contradictory. Our objective is to study whether zinc supplementation in INRs improves immune function, specifically by increasing CD4 counts, decreasing inflammation, and affecting other immune parameters.\n\nThis project involves a clinical trial where INRs will be randomly assigned to receive 75mg of elemental zinc daily (in the form of 3 zinc acetate tablets) along with their usual treatment or to continue their treatment without zinc supplements. We will assess whether zinc supplementation increases CD4 lymphocytes, reduces inflammation in INRs, and induces immune system changes. We will also investigate immune system functionality by measuring the presence of the Torque Teno Virus (TTV), a harmless virus, and see how zinc supplementation impacts its control by monitoring viral load changes.\n\nRecent research by our group has demonstrated that zinc has both antiviral and anti-inflammatory effects. Zinc supplementation is generally safe and well-tolerated, with few adverse effects. Zinc is available in various forms, including gluconate, acetate, and sulfate. Although the recommended daily dose is 40mg, studies have shown that doses exceeding 80mg have been safely administered for over 10 years without side effects.\n\nWe have selected a 75mg daily dose of elemental zinc for several reasons. Studies that showed no effect used lower doses (15-20mg\u002Fday), and our research found that 75mg\u002Fday improved outcomes in acute viral infections like Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV2). We believe previous failures to show zinc's efficacy were due to insufficient dosing. After extensive literature review, we concluded that 75mg daily is safe and likely to produce the desired effects.\n\nOur goal is to demonstrate the efficacy of zinc as an immunomodulatory agent. If successful, this could be a simple and cost-effective way to improve the quality of life for many people. We would recommend its widespread use under medical supervision, particularly at the doses being studied.",[27,28,29],"HIV","Zinc Status","HIV Infection",[31,32,33,34,35],"Zinc Supplementation","HIV Immunological Non-Responder","Immune response","immune activation","Inflammation","RECRUITING","2026-04-13",{"date":39,"type":40},"2026-04-16","ACTUAL",{"date":42,"type":40},"2025-01-02",{"date":44,"type":21},"2026-12",{"name":46,"class":47},"Parc de Salut Mar","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":55,"eligibilityCriteria":56,"healthyVolunteers":57,"sex":58,"minAge":59,"maxAge":60,"enrollmentInfo":61,"targetDuration":4,"studyType":63,"phases":4,"briefSummary":64,"conditions":65,"keywords":70,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":48},"100606081","dietary-patterns-inflammation-zinc-status-and-body-composition-in-multi-ethnic-women-of-reproductive-age-in-jakarta-100606081","NCT07170904","Dietary Patterns, Inflammation, Zinc Status, and Body Composition in Multi-Ethnic Women of Reproductive Age in Jakarta","The Relationship Between Dietary Patterns and Hair Zinc Levels With Body Composition, TNF-α, and Blood Pressure in Women of Reproductive Age (WRA) With Multi-Ethnicities in Jakarta: A Cross-Sectional Study","DIVERSE","Inclusion Criteria:\n\n* Women aged 19-49 years\n* Residing in Jakarta for at least 6 months\n* Currently menstruating (not menopausal)\n* From Minangkabau, Sundanese, Javanese, Betawi, or Chinese ethnicity\n* Not pregnant or breastfeeding at the time of study\n\nExclusion Criteria:\n\n* History of chronic diseases (e.g., diabetes, cardiovascular disease, cancer)\n* Currently on a medically prescribed diet or taking medication affecting nutrient status\n* Any condition interfering with accurate body composition measurement",true,"FEMALE","19 Years","49 Years",{"count":62,"type":21},188,"OBSERVATIONAL","This study aims to determine the relationship between dietary patterns and hair zinc levels with body composition, tumor necrosis factor alpha (TNF-α), and blood pressure in women of reproductive age from different ethnic backgrounds in Jakarta, Indonesia (specifically Minangkabau, Sundanese, Javanese, Betawi, and Chinese). Participants are assessed once through dietary assessment, anthropometric measurements, and biological sample collection.",[66,28,67,68,69],"Body Composition","Dietary Analysis","TNF Alpha","Blood Pressure",[71,72,73,74,75,76,77],"women of reproductive age","dietary assessment","hair zinc","TNF alpha","body composition","blood pressure","BOD POD","2025-11-26",{"date":80,"type":40},"2025-12-04",{"date":82,"type":40},"2025-02-03",{"date":84,"type":21},"2026-03-31",{"name":86,"class":47},"Indonesia University",{"id":88,"slug":89,"hasResults":11,"nctId":90,"briefTitle":91,"officialTitle":92,"acronym":4,"eligibilityCriteria":93,"healthyVolunteers":57,"sex":17,"minAge":94,"maxAge":95,"enrollmentInfo":96,"targetDuration":4,"studyType":22,"phases":98,"briefSummary":99,"conditions":100,"keywords":102,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":105,"lastUpdatePostDateStruct":106,"startDateStruct":108,"completionDateStruct":110,"leadSponsor":112,"locationsCount":48},"100607365","zinc-incorporated-bovine-derived--hydroxyappatite-xenograft-in-immediately-placed-implant-100607365","NCT07187609","Zinc Incorporated Bovine Derived- Hydroxyappatite Xenograft in Immediately Placed Implant","Clinical and Radiographic Evaluation of Zinc Incorporated Bovine Derived- Hydroxyappatite Xenograft in Immediately Placed Implant: A Randomized Clinical Study","Inclusion Criteria:\n\n* Adult(male or female) patients between the ages of 21 -50 years who requiring the replacement of one or more non-restorable teeth in the mandible which will be indicated for extraction.\n* Adequate bone dimensions at the implant site with ridge width of at least 6 mm, the availability of at least 3mm of sound subapical bone, the presence of an intact labial bone plate, and no evidance of periapical infection on cone beam computed tomography or clinically\n* The peri-implant gaps larger than 1.5 mm will be included.\n* All patients will be physically healthy with no medical history of any systemic disease.\n\nExclusion Criteria:\n\n* Smokers.\n* Patients with para functional habits such as bruxism and clenching\n* Poorly controlled systemic diseases which preclude local anesthesia or surgical procedures\n* Patients undergoing chemotherapy or radiotherapy and immuno-compromised patients.\n* Pregnant \u002Flactating women.\n* Patients that are allergic to zinc\n* Patients on antibiotic therapy in the pervious 6 months","21 Years","50 Years",{"count":97,"type":21},16,[24],"The aim of this study is to evaluate Clinical and radiographic effect of zinc incorporated bovine derived hydroxyapatite xenograft and bovine hydroxyapatite xenograft alone for immediately placed implant",[101,28],"Implant",[103,101,104],"bone grafts","zinc in corporated bovine drived hydroxyappatite","2025-09-18",{"date":107,"type":40},"2025-09-23",{"date":109,"type":40},"2025-08-13",{"date":111,"type":21},"2026-11-08",{"name":113,"class":47},"Suez Canal University"]