[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"zoonoses\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:zoonoses":31},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,49],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":32,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100637454","biomedical-signal-extraction-from-symptom-descriptions-an-observational-registry-using-the-opengenome-platform-100637454",false,"NCT07578610","Biomedical Signal Extraction From Symptom Descriptions: An Observational Registry Using the OpenGenome Platform","Accuracy and Calibration of Evidence-Grounded Biomedical Signal Extraction From Free-Text Symptom Descriptions: A Prospective Observational Registry Using the OpenGenome Automated Research Instrument","OGNOME-REG","* Automated or programmatically generated submissions detected by rate limiting\n* Submissions containing no discernible symptom or health-related content",true,"ALL","18 Years",{"count":21,"type":22},1000,"ESTIMATED","OBSERVATIONAL","This registry prospectively collects anonymized free-text symptom descriptions submitted voluntarily by adults through the OpenGenome platform at opengenome.bio. For each submission, the system retrieves real biomedical literature from PubMed and ClinicalTrials.gov in parallel, applies a constrained reasoning model operating under a strict output schema, and returns a structured biological signal report. The study evaluates the internal consistency of extracted signals, the calibration of confidence scores relative to dataset size and symptom specificity, and the distribution of biological signal categories across a large anonymous population. No intervention is assigned. No participant contact occurs. All data is anonymized at the point of collection.",[26,27,28,29,30,31],"Signs and Symptoms","Fever","Myalgia","Skin Diseases","Hemorrhagic Fever With Renal Syndrome","Zoonoses",[33,34,35],"biomedical signal extraction","symptom analysis","PubMed","RECRUITING","2026-05-16",{"date":39,"type":40},"2026-05-19","ACTUAL",{"date":42,"type":40},"2026-05-05",{"date":44,"type":22},"2028-05-30",{"name":46,"class":47},"OpenGenome","NETWORK",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":4,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":56,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":58,"conditions":59,"keywords":64,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":87},"100624599","establishment-of-a-biobank-for-the-evaluation-of-rapid-diagnostic-solutions-100624599","NCT07411729","Establishment of a Biobank for the Evaluation of Rapid Diagnostic Solutions","Establishment of a Biobank for the Evaluation of Rapid Diagnostic Solutions for Emerging Infectious Diseases and CBRN Threats - DiagRaMIE Biobanque","Inclusion Criteria:\n\n* Adults (≥ 18 years old) hospitalized in one of the participating centers at Bicêtre or Paul Brousse hospitals, for whom residual biological samples are available as part of routine care in one or more participating hospital departments.\n* Covered by, or entitled to, the French social security system (excluding State Medical Aid - AME).\n* Patient or legal representative\u002Ftrusted person informed about the registry and having provided written consent to participate.\n\nExclusion Criteria:\n\n* Patients under judicial protection (guardianship or curatorship).\n* Patients deprived of liberty by judicial or administrative decision.\n* Patients not speaking French and not accompanied by a translator.",{"count":57,"type":22},800,"This multicenter prospective registry aims to establish a biobank of residual biological samples and associated clinical data from hospitalized patients. The registry will collect a wide range of specimens (serum, plasma, respiratory samples, urine, cerebrospinal fluid, biopsies) obtained during routine care, without any additional procedures. Data are pseudonymized and stored securely for up to 20 years. The biobank will be used to develop and evaluate rapid diagnostic tests (RDTs) for emerging infectious diseases and CBRN threats to improve epidemic preparedness and patient management.",[60,61,62,31,63],"Emerging Infectious Diseases","Communicable Diseases","Biological Warfare Agents","Disease Outbreaks",[65,66,67,68,69,70,71,72,73,74,75,76],"Blood and blood derivatives: whole blood, serum, plasma, cord blood","Microbiological specimens: positive blood cultures","Urine samples","Respiratory samples","expectorations","bronchoalveolar lavage (BAL)","protected distal samples","bronchial aspirations","Cerebrospinal fluid","Stool or rectal swabs","Skin or mucosal swabs","Biopsies and puncture material: lymph node, hepatic, gastric, or other tissue samples when available","2026-02-09",{"date":79,"type":40},"2026-02-17",{"date":81,"type":40},"2024-06-03",{"date":83,"type":22},"2026-06-01",{"name":85,"class":86},"Assistance Publique - Hôpitaux de Paris","OTHER",10]