1-hour Premedication for Allergy Goal in Emergency: PAGE-1 is a prospective, parallel, two-arm, non-inferiority, randomized controlled trial evaluating the safety of a 1-hour (intervention) versus a 4-hour (standard regimen) intravenous (IV) premedication protocol in adult patients in the Emergency Department (ED) with a documented iodinated contrast allergy and requiring computed tomography (CT) imaging for a high-risk indication.
Adult (≥ 21 years old)
Documented iodinated contrast allergy in the electronic health record
CT with iodinated contrast ordered for a high-risk indication, † defined as post-arrest, concern for aortic dissection, ischemia, occlusion, obstruction, or other life-threatening conditions requiring timely diagnosis
Willing and able to give consent
Previous enrollment in this study
Pregnancy
Seafood or iodine allergy, alone
Gadolinium allergy
Paul Peng, MD PhD MSCR
Lead sponsor
Rutgers, The State University of New Jersey
Sponsor institution