Prospective, longitudinal, interventional, exploratory, non-randomized, single-center study including patients with pathological myopia .
Age ≥ 18 years and ≤ 55 years;
Patient consenting to be included in the study;
Examination and follow-up in at least one of the participating centers;
Severe pathological myopia with an axial length ≥ 26.5 mm in both eyes;
Identified genetic syndromic myopia, including Stickler syndromes type 1 and 2 (collagen 2A1 and 11A1), Marfan syndrome (fibrillin), Ehler-Danlos syndrome type 4 (lysyl-protocollagen hydroxylase), and Knobloch syndrome (collagen 18A).
Patient unwilling to participate or be followed up at one of the participating centers.
Binocular visual acuity ≥ 1 logMar (<0.1 on the decimal scale).
Media opacities preventing quality imaging, including cataracts.