[18F]F-FAPI PET-CT to Identify Carcinoma of Unknown Primary Origin
ConditionCancer of Unknown Primary
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-99
SponsorErasmus Medical Center
About this trial
The investigators will determine the proportion of CUP patients in whom the primary tumor can be identified by \[18F\]F-FAPI PET-CT.
Eligibility criteria
Qualifiers
Age ≥ 18 years old
Histologically-confirmed metastatic disease without identification of a primary tumor after standard diagnostic work-up, according to the national care pathway for CUP (in Dutch: Regionaal Zorgpad Primaire Tumor Onbekend), which includes at least an [18F]FDG PET-CT.
Disqualifiers
Patients with metastasis from a known primary tumor.
Sarcomas, melanomas, germ cell tumors, neuroendocrine tumors and haematological malignancies whose exact site of origin is not established.
History of malignancy within 5 years prior to [18F]F-FAPI PET-CT scan, with the exception of the cancer under investigation in this study and malignancies with a negligible risk of metastasis or death (e.g., 5-year OS rate > 90%), such as adequately treated carcinoma in-situ of the cervix, nonmelanoma skin carcinoma, localized prostate cancer, ductal carcinoma in-situ, or Stage I uterine cancer.
Prior systemic therapy for the treatment of CUP.
Trial design
Treatments tested in this trial
- [18F]F-FAPI PET-CT
Treatment groups
50 Participants
are divided into 1 treatment groupSponsors and collaborators
Erasmus Medical Center
Lead sponsor
Dutch Cancer Society
Collaborator
Academisch Ziekenhuis Maastricht
Collaborator
Missie Tumor Onbekend
Collaborator
Noordwest Ziekenhuisgroep
Collaborator
Cyclotron Noordwest BV
Collaborator
Source ClinicalTrials.gov