The purpose of this prospective randomized clinical trial is to compare the clinical outcomes between aspirin with ticagrelor versus aspirin with clopidogrel in high ischemic risk patients beyond 12 months after percutaneous coronary intervention with drug-eluting stent implantation
Age ≥50 years old
History of drug-eluting stent implantation due to acute myocardial infarction 12 to 24 months ago
High-risk for ischemic events (at least one of the following) 1) Age >65 years old 2) Medical treatments for diabetes mellitus 3) Multi-vessel coronary artery disease 4) More than 2 episodes of myocardial infarction 5) Chronic kidney disease (stage III or IV)
Age ≥85 years old
Pregnant women or women with potential childbearing
Life expectancy < 1 year
Inability to understand or read the informed consent