99Tc-MDP Treatment for Knee Osteoarthritis

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age40+
SponsorXinhua Hospital, Shanghai Jiao Tong University School of Medicine

About this trial

Osteoarthritis (OA) of knee is the most common form of arthritis in the world1e, and it has received growing attention in the society because of the increase of old age population, disabled people, and medical expenses from this disease. 99Tc-MDP is effective for rheumatoid arthritis. Therefore, the investigators try to investigate the effects of 99Tc-MDP treatment in patients with osteoarthritis of knee as compared with celecoxib.

Eligibility criteria

Qualifiers

Participants with painful osteoarthritis;

The standard uptake value (SUV) of OA related knee greater than 10 on 18F- sodium fluoride bone scan;

Participants voluntarily participate in the trial, and signed the informed consent.

Disqualifiers

Knee joint replacement;

Inflammatory arthritis or joint infection of knee;

Nervous joint disease;

Fracture of joint;

Trial design

Treatments tested in this trial

  • 99Tc-MDP
  • Celecoxib

Treatment groups

40 Participants
are divided into 2 treatment groups