The study aims to address the following questions:
1. Do subgroups defined by early medication choices, relapse, and medication taken over 20 years differ in clinical, cognitive, and functional outcomes? 2. What are the long-term cognitive functioning trajectories, what factors predict these trajectories, and how do they relate to outcomes? 3. What might be the mechanisms behind medication discontinuation and poor long-term outcome, including the roles of multiple relapses and treatment resistance after first-episode psychosis?
Eligible patients will be invited to a one-time face-to-face interview. A trained research assistant will guide the participants through questions about their background, clinical symptoms, daily functioning, cognitive abilities, and psychological well-being.
None
A diagnosis of schizophrenia or non-affective psychosis (schizophreniform disorder, schizoaffective disorder, brief psychotic disorder, or psychosis not otherwise specified) (DSM-IV)
Aged 18 to 65 years at the time of original enrolment
Had been treated with antipsychotic drugs for at least 12 months
No history of relapse or exacerbation or had to be asymptomatic (free of positive symptoms of psychosis) at study entry.
The University of Hong Kong
Lead sponsor
Research Grants Council, Hong Kong
Collaborator