A Combined Multidomain Intervention to Prevent Cognitive Decline Associated With Cardiovascular Risk Factors.

ConditionsAging Cardiovascular Risk Factor

Trial statusRecruiting

Trial phaseNot applicable

Trial typeInterventional

Biological sexAll

Age60+

SponsorLouis Bherer

About this trial

The ACTIONcardioRisk trial is designed to investigate the effect of aerobic and progressive resistance training exercises combined with cognitive training, on neurocognitive functioning of sedentary older adults with and without cardiovascular risk factors.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Adult aged 60 and older,

Normal or corrected vision and normal hearing for their age range,

No cognitive impairment (Mini-Mental State Examination - MMSE ≥ 25),

Inactive (< 150 min of physical activity per week).

Disqualifiers

MMSE ≤ 24 or diagnosis of dementia,

Uncontrolled psychological / psychiatric condition within the past 6 months,

Neurological disease,

Severe exercise intolerance,

Trial design

Design model

Parallel

Treatments tested in this trial

Cognitive Training
Other intervention
Participants will be encouraged to perform sessions of cognitive training 3 times per week (30 minutes/session). Two of these sessions will involve computer- or tablet-based attentional control training targeting dual-tasking, updating and working memory, as well as inhibition and switching. Difficulty of cognitive training will be tailored to participants' performances. The remaining session will consist of memory training. Participants will be instructed mnemotechnic, as well as be taught about memory in aging in general.
Aerobic and resistance exercises
Other intervention
Participants will follow a periodized exercise training program with thrice-weekly 60 minutes trainings. The sessions will start with a 5-10mins warm-up, followed by aerobic and resistance trainings, and ends with a 5-10mins cool-down and stretching period. Intensity of aerobic sessions will be monitored with heart rate chest strap and should match with the moderate to vigorous intensity zone as defined by the ACSM (65% of Heart Rate maximum or more and a Perceived Exertion higher than 12 on the 6 to 20 Borg scale). Exercise intensity and duration will be gradually increased during the program. After aerobic training, a 15-20mins resistance training will be performed with a gradual progression of higher intensities and/or numbers of sets. The one maximal repetition (1RM) will be assessed for each RT movements at baseline, during (each 3 months) and at the end of the program. RT intensities will go from 40 to 70% of 1RM, with 8 to 10 forms of exercise involving majors muscle groups.
Stretching and Toning
Other intervention
Participants in the active control condition will take part in three 60 minutes stretching and toning sessions per week. Each session will start with a five-minutes warm-up, followed by fifteen min of body stretching exercises mainly in a seated position and finish with a five-minutes cool down. Participants will engage in four muscle-toning exercises (light intensity) using dumbbells or resistance bands, two exercises designed to improve balance, one yoga sequence, and one exercise of their choice. Intensity of stretching and toning sessions will be monitored with heart rate chest strap and should not exceed the light intensity zone as defined by the ACSM (64% of Heart Rate maximum or less and a Perceived Exertion lower than 11 on the 6 to 20 Borg scale).

Treatment groups

159 Participants

are divided into 3 treatment groups

Group A: Multidomain interventionExperimental treatment 2 interventions

Group B: Physical exercise interventionExperimental treatment 1 intervention

Group C: Active control interventionActive comparator 1 intervention

Trial outcomes

Primary outcomes

Change in general cognitive functioning

Montreal Cognitive Assessment (0-30 score, with a higher score indicating a better cognitive functioning).

Time frame