About this trial
The goal of this observational study is to learn about the treatment effectiveness of physician's choice of chemotherapy and the immune checkpoint inhibitor (ICI)-based therapy in patients with relapsed/refractory ovarian clear cell carcinoma (OCCC), and compare the treatment response with the phase II, single-arm clinical trial INOVA to investigate the efficacy of combinational therapy of sintilimab plus bevacizumab. The main questions it aims to answer are:
* What is the efficacy of physician's choice of chemotherapy in relapsed/refractory OCCC patients in the real world? * Is ICI-based therapy more effective than physician's choice of chemotherapy in real-world for relapsed/refractory OCCC patients? * Dose the combinational regimens of sintilimab plus bevacizumab in Sintilimab Plus Bevacizumab in Recurrent/Persistent Ovarian Clear Cell Carcinoma (INOVA) trial more effective than physician's choice of chemotherapy?
Participants will be respectively retrieved and extracted de-identified, longitudinal electronic health records (EHR)-derived data.
Eligibility criteria
Qualifiers
Female patients with age ≥ 18 years old and ≤ 75 years old.
There must be a histological diagnosis of ovarian clear cell carcinoma.
Patients with recurrent or persistent ovarian clear cell carcinoma must have at least one-line pretreated platinum-containing chemotherapy.
Eastern Cooperative Oncology Group (ECOG) performance status score ≤ 2.
Disqualifiers
None
Trial design
Treatments tested in this trial
- physician's choice of chemotherapy
- immune checkpoint inhibitor based therapy
Treatment groups
Sponsors and collaborators
Tongji Hospital
Lead sponsor
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Collaborator
Henan Cancer Hospital
Collaborator
Qilu Hospital of Shandong University
Collaborator
Hubei Cancer Hospital
Collaborator
Anhui Provincial Cancer Hospital
Collaborator
Peking University Cancer Hospital & Institute
Collaborator
Hunan Province Tumor Hospital
Collaborator
First Affiliated Hospital of Suzhou Medical College
Collaborator
Shandong Tumor Hospital
Collaborator
Chongqing University Cancer Hospital
Collaborator
First Affiliated Hospital of Zhongshan Medical University
Collaborator
Peking University Shenzhen Hospital
Collaborator