A Correlation Study of Cognitive Function in Patients With Depression
ConditionDepression
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-60
SponsorCentral South University
About this trial
Many studies have shown that patients with depression had weak brain region connections and low levels of activation of the prefrontal lobe when brain activity was active and that patients with depression have a negative attentional bias, and the patient's abnormal attentional allocation may stem from a loss of attention avoidance of negative cues and a loss of attention preference for positive cues. Here use the near-infrared, eye movement to evaluate the cognitive function in patients with depression. The purpose of the study is to explore the correlation between depressed symptom and cognition function among the depression patients and the difference between first-onset of depressed patients and those is recurrent.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Meets the DSM-5 (Diagnostic and Statistical Manual of Mental Disorders, 5th Edition) diagnostic criteria for depressive disorders
Age 18-60 years, gender aside, at least 1 guardian to monitor the patient for 2 months
Obtain informed consent from patients and guardians, sign informed consent forms, and be able to comply with planned visits, laboratory tests, and other research procedures
It is expected that there will be no problems such as relocation of residence, inconvenience of transportation, and difficulty in obtaining medical treatment throughout the study process
Disqualifiers
Presence of any other medical disorder affecting reproductive endocrine function; Abusers of psychoactive substances or substances such as alcohol
People with severe physical disabilities who are unable to complete follow-up
Have been diagnosed or have had other severe psychiatric disorders that meet the diagnostic criteria for DSM-5, mental retardation, dementia, severe cognitive dysfunction, etc
Previously or currently suffering from any major physical disease, neurological disorder, brain trauma, etc. that affect the structure or function of the brain
Trial population
First-onset of depressed patients and patients with recurrent depression
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
No intervention
Other interventionNo intervention
Treatment groups
200 Participants
are divided into 2 treatment groupsGroup A: First-onset of depressed patients1 intervention
Group B: Patients with recurrent depression1 intervention
Trial outcomes
Primary outcomes
1
Change in Hamilton Depression Scale (HAMD-17)
Scores ranging from 0-54, with higher scores indicating more severe symptoms
Time frame
Baseline, the first month, the second month and the third month2
Change in Pittsburgh Sleep Quality Scale (PSQI)
Scores ranging from 0-21, with higher scores indicating more severe symptoms
Time frame
Baseline, the first month, the second month and the third month3
Changes in Beck Suicidal Scale Inventory (BSI)
Scores ranging from 0-100, with higher scores indicating more severe symptoms
Time frame
Baseline, the first month, the second month and the third month4
Changes in selective attention through eye-tracking task.
Eye-tracking task was performed using the free-viewing paradigm. By presenting images of irritable, threatening,positive, and neutral emotional scenes, the subject's selective attention was measured.
Time frame
Baseline, the first month, the second month and the third monthSecondary outcomes
1
Change in Hamilton Anxiety Scale (HAMA)
Scores ranging from 0-56, with higher scores indicating more severe symptoms
Time frame
Baseline, the first month, the second month and the third month2
Change in Young's Mania Scale (YMRS)
Scores ranging from 0-60, with higher scores indicating more severe symptoms
Time frame
Baseline, the first month, the second month and the third monthSponsors and contacts
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Source ClinicalTrials.gov
This trial is not recruiting at the moment. You can still explore other options: