A Danish ICD-study in Patients with Coronary Artery Disease Resuscitated from Ventricular Fibrillation

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorRigshospitalet, Denmark

About this trial

DanICD is a randomized, controlled study to with the aim to assess whether there is a benefit of ICD-implantation in patients with coronary artery disease (including acute myocardial infarction), who survive cardiac arrest due to ventricular fibrillation/sustained ventricular tachycardia and undergo revascularization and with an LVEF above 35%.

Eligibility criteria

Qualifiers

Patients with CAD and cardiac arrest due to VF/VT, where angiogram is performed with complete revascularization (PCI, CABG or hybrid coronary revascularization) before ICD implantation. Unfavorable artery for PCI (i.e., excessive vessel tortuosity or chronic total occlusion) or high-risk invasive treatment is not mandatory in order to achive complete revascularization.

Age ≥18 years

LVEF >35% at the time of discharge. The most recent LVEF assessment on which the current medical treatment will be based at the time of entry into the study will be used as baseline LVEF.

Disqualifiers

Non-ischemic cause of cardiac arrest (i.e. ion channel diseases, non-ischemic cardiomyopathy)

Previous CABG within the last 3 months before index hospitalization

Life expectancy less than 1 year or severe neurologic outcome

Unable or unwilling to give informed consent

Trial design

Treatments tested in this trial

  • Implantable cardioverter defibrillator

Treatment groups

1,200 Participants
are divided into 2 treatment groups

Sponsors and collaborators