A Digital Cognitive Intervention for Intrusive Memories After Trauma

Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-50
SponsorZhu Zijian

About this trial

Intrusive traumatic memories frequently trigger severe distress and psychological disorders like PTSD. Traditional therapies require explicit trauma recall, which often causes severe patient distress and leads to treatment avoidance. To address this, our study introduces a novel, less aversive intervention combining unconscious visual processing with bilateral eye movement to mitigate these intrusive memories.

Utilizing a randomized, three-arm design (comparing standardized trauma-related images, patient-provided images, and neutral images, all paired with bilateral eye movements), we plan to recruit participants who have experienced severe trauma and report ≥ 5 intrusive memories weekly, targeting a final sample of 40 patients per arm. The primary outcome is the frequency of intrusive memories. Secondary and additional outcomes include PTSD severity (CAPS-5, PCL-5, IES), depression, anxiety, borderline symptoms, functional improvements, subjective intervention distress, and dropout rates.

Eligibility criteria

Qualifiers

Meet DSM-5 Criterion A for PTSD, which stipulates exposure to an event involving serious injury or a threat to one's own or another's physical well-being, either through direct experience or witnessing.

Participants needed to exhibit symptoms from at least three of the five core PTSD symptom domains outlined in DSM-5: intrusive memories (Criterion B), persistent avoidance of trauma-related stimuli (Criterion C), negative alterations in cognitions and mood (Criterion D), alterations in arousal and reactivity (Criterion E), and symptoms lasting for at least one month (Criterion F).

The total score of CAPS-5 ≥ 33.

Have internet access and have access to a personal computer.

Disqualifiers

Fewer than 5 intrusive memories during the baseline week (Week 0).

IQ score lower than 80.

A current diagnosis of schizophrenia, obsessive-compulsive disorder (OCD), a severe personality disorder judged to interfere with treatment adherence, or acute suicidal behavior.

Have severe substance dependence.

Trial design

Treatments tested in this trial

  • Pre-selected Trauma-related Cue Images with Eye Movement
  • Patient-provided Trauma-related Cue Images with Eye Movement
  • Neutral Images with Eye Movement

Treatment groups

123 Participants
are divided into 3 treatment groups

Locations

This trial has no locations

Sponsors and collaborators

Zhu Zijian

Lead sponsor

Shaanxi Normal University

Sponsor institution