This observational study aims to establish a national cohort of patients with hydatidiform mole (molar pregnancy) to investigate its malignant transformation rate and malignant transformation mechanisms, with the goal of developing and promoting precision diagnosis and treatment models across China.
Clinically or pathologically diagnosed as hydatidiform mole.
Availability of complete medical records, including clinical and pathological data.
No evidence of myometrial invasion or metastasis.
Serum hCG levels normalized after uterine evacuation with at least 6 months of follow-up, OR diagnosed with postmolar gestational trophoblastic neoplasia (pGTN) during follow-up.
Missing clinical data.
Loss to follow-up: Do not return to participating hospital for follow-up visits after uterine evacuation, or could not be contacted for subsequent monitoring of hCG changes.
Concomitant malignancies or autoimmune deficiency disorders (e.g., systemic lupus erythematosus, myasthenia gravis, HIV infection, etc.).
As determined by the investigator, the presence of medical, psychological, social, occupational, or other conditions that would violate the study protocol or impair the subject's ability to provide informed consent.
Obstetrics & Gynecology Hospital of Fudan University
Lead sponsor
Peking Union Medical College Hospital
Collaborator
Shengjing Hospital
Collaborator
Hebei Medical University Third Hospital
Collaborator
Hainan women and children medical center
Collaborator
Shenzhen Maternity & Child Healthcare Hospital
Collaborator
Third Affiliated Hospital of Zhengzhou University
Collaborator
Shanghai First Maternity and Infant Hospital
Collaborator
International Peace Maternity and Child Health Hospital
Collaborator
Shandong University
Collaborator
First Affiliated Hospital of Zhejiang University
Collaborator
The Affiliated Hospital of Qingdao University
Collaborator
Gansu Provincial Maternity and Child-care Hospital/Gansu Provincial Central Hospital
Collaborator
Dalian women and children's medical group
Collaborator