A study conducted in Finland discovered that a multidomain intervention, consisting of physical activity, nutritional guidance, cognitive training, social activities, and management of vascular risk factors, effectively decelerated cognitive decline in healthy older adults who were at an increased risk of cognitive decline. The HERITAGE study is a 2-year clustered randomized controlled trial (clustered-RCT) that explores the efficacy of a multidomain intervention among 1200 elderly residents with a higher risk of cognitive decline and dementia in Zhejiang Province, China
At risk of cognitive decline: cognitive performance at the mean level or slightly lower than expected for age with no dementia (AD8>=3 and/or 5-min MoCA >, < 11)
Free of physical disabilities that preclude participation in the study
Willing to complete all study-related activities for 24 months
Willing to be randomized to either lifestyle intervention group
Diagnosed dementia patients
Diagnosed major depression or other neuropsychological diseases
Malignant diseases
Symptomatic cardiovascular disease