The goal of this observational study is to expound the population and characteristics of pathogenic microorganisms with co-infection, draw the pedigree of pathogenic microorganisms, and evaluate its influence on disease outcome in patients with severe hepatitis (liver failure). The main questions it aims to answer are:
* Mapping of infectious agents in patients with severe hepatitis (liver failure) * Constructing early warning predictive models to explore how to give an individualized regimen of integrated immune function.
Patients agreed to participate in the study and signed an informed consent form;
Sex is not limited and age is 18-70 years old;
HBsAg positive for more than 6 months, or hepatitis E IgM positive, or hepatitis E RNA positive;
Progressive deepening of jaundice in a short period of time (serum total bilirubin greater than 10 times the upper limit of normal or rising ≥17.1 umol/L per day);
Patients with severe hepatitis caused by other non-hepatophilic viral infections;
Patients who were considered by the investigator to be unsuitable for participation in the study.
Zhejiang University
Lead sponsor
Beijing Ditan Hospital
Collaborator
Beijing YouAn Hospital
Collaborator
Huashan Hospital
Collaborator
Qilu Hospital of Shandong University
Collaborator