This is a prospective, multicenter, observational real-world study to explore the therapy patterns and clinical outcomes of Avapritinib in patients with metastatic or unresectable gastrointestinal stromal tumors.
Patients who are aged ≥ 18 years.
Gastrointestinal stromal tumors confirmed by histopathological examination, and CD- and/or DOG-1-positive by immunohistochemistry.
Presence of mRECIST v1.1-compliant lesions with at least one measurable lesion (non-lymphadenopathy ≥1.0 cm or ≥2-fold scan slice thickness).
Treatment with Avapritinib.
KIT or PDGFRA wild type.
Failure to complete continuous atorvastatin for at least 15 days due to intolerability or disease progression.
Other serious acute or chronic physical or mental problems, or laboratory abnormalities, may increase the risk associated with participation in the study or use of drugs, or interfere with the judgment of the study results and, in the judgment of the investigator, are not considered appropriate for participation in the investigator.
Xinhua Zhang, MD
Lead sponsor
First Affiliated Hospital, Sun Yat-Sen University
Sponsor institution
Peking University Cancer Hospital & Institute
Collaborator
Fudan University
Collaborator
Peking University People's Hospital
Collaborator
Chinese PLA General Hospital
Collaborator
Xiangya Hospital of Central South University
Collaborator
Peking University Shenzhen Hospital
Collaborator
Nanfang Hospital, Southern Medical University
Collaborator
West China Hospital
Collaborator
Jiangsu Cancer Institute & Hospital
Collaborator
Shanghai Zhongshan Hospital
Collaborator
Sun Yat-Sen University Cancer Center
Collaborator
Xijing Hospital
Collaborator
Shengjing Hospital
Collaborator
Shanghai Jiao Tong University School of Medicine
Collaborator
Liaoning Cancer Hospital & Institute
Collaborator
Sixth Affiliated Hospital, Sun Yat-sen University
Collaborator
Fujian Medical University Union Hospital
Collaborator
Cancer Hospital of Guangxi Medical University
Collaborator
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Collaborator
First Affiliated Hospital of Chongqing Medical University
Collaborator
Chongqing University Cancer Hospital
Collaborator