This study aims to demonstrate the impact of Endocrine-Disrupting Chemicals (EDCs) on the risk of hypospadias incidence. It is a multicenter comparative case-control study, involving two groups. The first group consists of biological mothers who have given birth to children with hypospadias (Case Group), while the second group consists of biological mothers who have given birth to children without any malformations (Control Group). Through an integrative approach that combines a direct toxicological study of numerous pollutants present during pregnancy, and a comprehensive exposome assessment using validated tools, this study can significantly enhance our understanding and prevention of this malformation.
Parents of legal age having signed a free and informed consent for the participation of their child
Biological mother of a boy aged between 1 and 6 months
Biological mother with a minimum hair length of 18 cm
Biological mother who has signed a free and informed consent for her participation
Child with another congenital anomaly or malformative syndrome
Child with an endocrine pathology
Biological mother or child under legal protection, guardianship, or curatorship
Biological mother or child in the exclusion period of a previous study