A Natural History Study of Metabolic Sizing in Health and Disease
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age2-99
SponsorNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
About this trial
Background:
Scientists have long used simple measures (such as height and weight) to estimate how much a person s body uses food (calories) as energy, as commonly called the metabolic rate. But metabolism varies among people with similar body sizes. Scientists now believe the old formulas for estimating metabolic rates may not work well for all people. Researchers want to find more accurate ways to measure a person s metabolism.
Objective:
This natural history study will examine the relationships between metabolism, body composition, and body surface area in a wide range of people.
Eligibility:
Healthy children and adults aged 2 years or older. Also, people aged 2 years or older with conditions that may alter metabolism. These may include diabetes, obesity, renal disease, or cancer.
Design:
Participants will spend 2 days and 1 night in the hospital. They will provide a medical history and answer questions about their activity levels, the foods they eat, and their lifestyle. They will also eat a special diet.
Participants will undergo many tests:
They will lie in a bed with a clear hood covering their head for 30 to 45 minutes to measure the gases in their breath.
They will lie on a padded table for about 15 minutes while their body is scanned.
They will stand on a platform while a 3D scanner measures their body.
They will have a test to measure how fast an electric signal moves through their body.
They will grip an instrument to measure the strength of their hands.
They will drink salty water and provide blood and urine samples.
Participants may be invited to return for these 2-day visits up to 8 times per year. Return visits must be at least 2 weeks apart.
Eligibility criteria
Qualifiers
Male or female, aged >=2 years
In good general health as evidenced by medical history
Male or female, aged >=2 years
Diagnosed with diseases thought to alter metabolism or body composition (such as weight loss or gain, diabetes, renal disease, obesity, cancer, etc.) or taking medications thought to alter metabolism or body composition.
Disqualifiers
Participants over 200 kg due to the weight limit of the equipment.
Presence of any implanted device that would interfere with measurements.
Any moderate to severe limitations in mobility that would impede participation
Hemoglobin less than 10 g/dL (in participants who would have blood drawn for research purposes).
Trial design
Treatments tested in this trial
- Not listed
Trial groups
2,000 Participants
are grouped into 2 trial groupsSponsors and collaborators
Source ClinicalTrials.gov