The study conducted on cancer patients is designed to test safety and efficacy of limb hypothermia in cancer patients using the new Paxman Limb Cryocompression System (PLCS). Ultimately this will lead to the development of a therapy regime that will help to prevent chemotherapy-induced neuropathy in cancer patients.
Age 21- 80 years.
Signed informed consent from patient or legal representative
Scheduled to receive weekly paclitaxel chemotherapy
Patients may receive other chemotherapy drugs alongside taxane e.g. Platinum/Herceptin.
Open skin wound or ulcers of the limbs
History of Raynaud's phenomenon, peripheral vascular disease, or poorly controlled diabetes
Pregnant woman
A score of more than 5 in Total Neuropathy Score (TNS) at baseline for cancer patients
National University Hospital, Singapore
Lead sponsor
Paxman Coolers Ltd.
Collaborator
National University of Singapore
Collaborator
Curie Oncology, Mount Elizabeth Novena Specialist Centre
Collaborator
Ng Teng Fong General Hospital
Collaborator