A Novel Multi-Modal Approach to Promote Functional Outcomes in Cognitively Frail Older Adults
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age60-90
SponsorThe Hong Kong Polytechnic University
About this trial
The goal of this clinical trial is to explore the effects of intermittent theta burst stimulation (iTBS) primed with theta burst stimulation (cTBS), on top of aerobic exercise, on cognitive function, mobility, and brain activity in older adults with cognitive frailty. Understanding these effects will help us develop intervention models that benefit cognitively frail older adults. The main questions it aims to answer are:
1. Does the combination of iTBS primed with cTBS and aerobic exercise lead to greater improvements in cognition and mobility in older adults with cognitive frailty compared to non-priming iTBS and sham stimulation? 2. What are the neural mechanisms responsible for the improvements in cognition and mobility associated with the combination of iTBS primed with cTBS and aerobic exercise in older adults with cognitive frailty?
Eligibility criteria
Qualifiers
be between 60 and 90 years old;
scored < 9/12 on the SPPB;
scored >18/30 on the MoCA;
scored >9/42 on the PFFS;
Disqualifiers
have magnetic resonance imaging (MRI) contraindications;
have aerobic exercise contraindications;
have transcranial magnetic stimulation contraindications;
be diagnosed with neurodegenerative conditions (i.e., dementia, Parkinson's, Alzheimer's disease, Amyotrophic lateral sclerosis, and stroke);
Trial design
Treatments tested in this trial
- Theta burst stimulation
- Aerobic exercise
Treatment groups
45 Participants
are divided into 3 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov