The purpose of this study is to determine the efficacy and safety of a personalised surveillance and intervention protocol for patients with familial adenomatous polyposis (FAP) that have undergone (procto)colectomy.
Diagnosis of FAP, at least one of following: genetic diagnosis (proven APC germline mutation) and/or clinical diagnosis (>100 colorectal adenomas in combination with a positive family history of FAP)
Have undergone prophylactic (procto)colectomy with IRA/ISA or IPAA
Age 18 years or older
Not able to remove all polyps with an indication for removal during (multiple) clearing endoscopies
Cancer at baseline endoscopy
Need for surgery
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Lead sponsor
Leiden University Medical Center
Collaborator
The Netherlands Cancer Institute
Collaborator
St Mark's Hospital Foundation
Collaborator
Hospital Clinic of Barcelona
Collaborator
Maria Sklodowska-Curie National Research Institute of Oncology
Collaborator
Hospital General Universitario de Alicante
Collaborator
IRCCS Azienda Ospedaliero-Universitaria di Bologna
Collaborator
Radboud University Medical Center
Collaborator
Hvidovre University Hospital
Collaborator
M.D. Anderson Cancer Center
Collaborator
University Hospital, Bonn
Collaborator