Caloric restriction may alter the response to chemotherapy induced stress response and enhance its antitumor effect. This study intends to use an intermitted caloric restriction protocol with alternate days before the chemotherapy administration to enhance the cytotoxic effect generated by standard treatment of cancer.
• Histologically documented, cancer patients who are eligible to receive cytotoxic chemotherapy.
Life expectancy of at least 6 months
Adults ≥ 18 years of age
White blood cell (WBC) ≥ 2,500 cells/μL
• Eastern Cooperative Oncology Group (ECOG) performance status 2 or higher
Systemic corticosteroids; however, use of inhaled, intranasal, and topical steroids is acceptable.
High dose calcitriol [1,25(OH)2VitD] (i.e., > 7.0 μg/week)
Any infection requiring parenteral antibiotic therapy or causing fever (temperature > 100.5°F or 38.1°C) within 1 week prior to registration