A Prospective Study of REPeat Ablation In Patients With Recurrent PERSistent Atrial Fibrillation: Pulmonary Vein Isolation vs. Adjunct Posterior Wall Isolation (REPAIR PERS-AF Study)

Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-80
SponsorHaukeland University Hospital

About this trial

This study aims to investigate the best strategy for repeat ablation of recurrent persistent atrial fibrillation (AF) after previous persistent AF ablation involving pulmonary vein isolation (PVI) along. Patients with low voltage areas on the posterer wall will be randomized to PVI alone or the posterer wall isoaltion (PWI) in addition to PVI.

Eligibility criteria

Qualifiers

Symptomatic patients with persistent AF and indication for repeat ablation

procedure.

Patients with recurrent persistent AF (with a duration <3 year, at least one episode longer than 7 days during the last 6 months and have been electrically cardioverted at least once during the last 12 months) after previous catheter ablation.

Patients with up to two previous catheter ablations for AF are included if the procedures only involved PVI. Previous PVI procedure(s) with both cryoablation and radiofrequency ablation are accepted.

Disqualifiers

Patients with >2 ablation procedures in the LA for AF or atrial flutter

Previous ablation procedures for AF involving ablation strategies beyond PVI

Duration of persistent AF >3 years

Presence of atrial flutter or atrial tachycardia

Trial design

Treatments tested in this trial

  • Radio frequency ablation

Treatment groups

150 Participants
are divided into 3 treatment groups

Locations

This trial has no locations

Sponsors and collaborators

Haukeland University Hospital

Lead sponsor

St. Olavs Hospital

Collaborator

University Hospital of North Norway

Collaborator