A Randomized Clinical Trial Comparing Embryo Euploidy Rates Following Ultrashort Versus Standard Abstinence
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-42
SponsorUConn Health
About this trial
This research is being done to determine if producing sperm after an ultrashort period of abstinence (1 hour of abstinence) will be effective in improving the rates of embryos with normal chromosomes (structures that carry genetic information) during in vitro fertilization (IVF) treatment. The investigators hypothesize that a shorter period of abstinence is effective at improving rates of normal chromosomes among embryos.
Eligibility criteria
Qualifiers
Subjects are nonpregnant females ≥ 18 years and ≤ 42 years of age.
Subjects obtain greater than or equal to 6 mature oocytes at the time of oocyte retrieval for ICSI or greater than or equal to 8 oocytes at the time of oocyte retrieval for standard insemination.
Subjects are utilizing standard insemination or ICSI for fertilization.
Subjects are undergoing PGT-A (PGT for aneuploidy) or PGT-M (PGT for monogenic disorders).
Disqualifiers
Subjects are utilizing donor oocytes, donor sperm, or gestational carrier.
Subjects have a diagnosis of cryptozoospermia (no spermatozoa identified in fresh semen sample).
Subjects are utilizing surgically removed sperm (e.g. via testicular sperm aspiration [TESA] or microsurgical epididymal sperm aspiration [MESA]).
Subjects are utilizing frozen/thawed sperm, including in cases in which a fresh sample was planned and the sample is insufficient for use.
Trial design
Treatments tested in this trial
- Ultrashort abstinence
- Standard abstinence
Treatment groups
187 Participants
are divided into 2 treatment groupsSponsors and collaborators
UConn Health
Lead sponsor
The Center for Advanced Reproductive Services, P.C.
Collaborator
Source ClinicalTrials.gov