A RCT on the Preventive Effect of HFNC on Postoperative Pulmonary Complications in Patients With Gynecologic Neoplasms

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexFemale
Age18-90
SponsorSichuan Cancer Hospital and Research Institute

About this trial

Patients at high risk of post-operative pulmonary complications (PPC) will be screened out from gynecological tumor patients undergoing surgical treatment, and randomly assigned into the HFNC group and control group, which uses conventional nasal cannula oxygen therapy. The primary outcome is the incidence of PPC, including postoperative hypoxemia, atelectasis, pneumonia, etc. Secondary outcomes are the improvement of postoperative oxygenation, antibiotic use, length of hospital stay, adverse events related to oxygen therapy, etc.

Eligibility criteria

Qualifiers

Assess respiratory risk in surgical patients in Catalonia (ARRSPC) ≥45 points;

BMI≥30;

Moderate to severe asthma;

Moderate to severe chronic obstructive pulmonary disease (COPD);

Disqualifiers

Patients with lung metastasis of malignant tumor or primary lung malignant tumor;

previous lung surgery or radiotherapy;

the surgery involved segmental bowel resection.

Trial design

Treatments tested in this trial

  • heated humidified high flow nasal cannula oxygen therapy, HFNC
  • Nasal cannula oxygen

Treatment groups

200 Participants
are divided into 2 treatment groups