The aim of this study was to evaluate the effect of flash stimulation therapy on the function of the cerebral glymphatic system and efficacy of improving symptoms in PD patients.
PD patients who meet the diagnostic criteria of the International Movement Disorders Association (MDS), between the ages of 50 and 70 years, the course of disease ≤5 years, and the Hoehn & Yahr stage ≤3;
Anti-PD drugs were taken regularly for at least one month before screening, and symptoms were stable;
The fixed bedtime in the past month is between 9:00 p.m. and 1:00 a.m., and the total sleep time is ≥6 hours;
Have the ability to understand and voluntarily sign informed consent;
Secondary insomnia: including sleep disorders (restless leg syndrome, periodic limb movement disorder, sleep-related breathing disorders, etc.), physical diseases, mental disorders, psychoactive substance abuse;
suffering from photosensitive dermatitis, epilepsy and other diseases that are not suitable for flash stimulation;
Alcohol, coffee, or drug abusers in the past 6 months;
Mental illness: such as anxiety, depression, schizophrenia and post-traumatic stress disorder caused by insomnia;