A Study of Cardiac Magnetic Resonance Imaging (CMR) for Evaluating Catheter-Associated Right Atrial Clot in People With Cancer

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorMemorial Sloan Kettering Cancer Center

About this trial

The researchers are doing this study to see how well cardiac magnetic resonance imaging (CMR) scans can be used to examine the properties of central venous catheter-associated right atrial clot (RA clot). This could help doctors decide on the best treatment options.

Eligibility criteria

Qualifiers

Documentation of Disease

Definition of Disease [or Measurable Disease]

Cardiac mass (CMASS) will be initially localized on cine-CMR, on which it is defined via established criteria as a discrete tissue prominence independent from normal anatomic structures, quantified based on size (area, cross-sectional linear dimensions)

CMASS will be further categorized by type (CNEO or CTHR) based on CMR tissue characterization: CNEO and CTHR can be differentiated based on presence of contrast enhancement via the reference standard of LGE-CMR using established criteria previously validated by our group and others.

Disqualifiers

Known pre-existing CV disease which can affect hemodynamics within cardiac chambers as determined by the investigator, including

Arrhythmia - chronic persistent atrial arrhythmias

Cardiomyopathies including Ischemic or non-ischemic cardiomyopathy with LVEF <53%

Restrictive cardiomyopathy - cardiac amyloidosis, myocardial fibrosis

Trial design

Treatments tested in this trial

  • Cardiac MRI

Treatment groups

150 Participants
are divided into 1 treatment group

Sponsors and collaborators

Memorial Sloan Kettering Cancer Center

Lead sponsor

American Heart Association

Collaborator