A Study of Neurodegeneration and Neuronal Fluctuations in Lewy Body Disease and Alzheimer's Disease
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age50-95
SponsorMayo Clinic
About this trial
The purpose of this research study is to investigate how the brain, memory, thinking, and motor behavior change both in individuals with movement and/or cognitive disorders, as well as healthy individuals. Researchers will look at measurements of memory, thinking, brain wave and muscle activity, daily functioning, and brain scans to learn more about brain disorders such as Alzheimer disease and Lewy body disease.
Eligibility criteria
Qualifiers
Use English as their primary language.
Be willing to undergo health and cognitive assessments, as well as brain MRI and EEG study.
Will be encouraged to have an available study partner (also called a "co-participant") who is familiar with the participant's daily functioning.
This study will be limited to healthy individuals, and patients who have a clinical diagnosis made by a board-certified neurologist of Lewy body disease or Alzheimer disease.
Disqualifiers
All participants will receive copies of the signed ICFs (including signatures of those obtaining consent).
All participants have the right to withdraw from the study at any time.
Individuals will be excluded if they have significant sensory (visual and hearing) deficits or major medical or psychiatric illnesses which would limit participation.
Participants will also be excluded if they have history of other major neurologic disorders including stroke, epilepsy, meningitis/encephalitis, metabolic or toxic encephalopathy, penetrating or severe closed head injury, brain tumor/other structural lesion, other primary movement disorders (such as essential tremor, dystonia, chorea, multiple system atrophy, progressive supranuclear palsy, corticobasal syndrome).
Trial design
Treatments tested in this trial
- Magnetic Resonance Imaging
- Electroencephalography
- Electromyography
Treatment groups
90 Participants
are divided into 3 treatment groupsSponsors and collaborators
Mayo Clinic
Lead sponsor
National Institute on Aging (NIA)
Collaborator
Source ClinicalTrials.gov