About this trial
To evaluate the efficacy and safety of iNK cells infusion in patients with chronic active Epstein-Barr virus infection (CAEBV) and EBV-associated hemophagocytic lymphohistiocytosis (EBV-HLH) after allogeneic hematopoietic stem cell transplantation (allo-HSCT)
Eligibility criteria
Qualifiers
≤65 years,ECOG :0-2;
Cardiac EF≥40%, creatinine clearance ≥50%; aminotransferase(ALT/AST)<200U/L。;
In patients with HLH, HLH efficacy ≥Partial Response after prior treatment is required;
Estimated survival time is longer than three months;
Disqualifiers
Patients with evidence of grade II or more serious heart disease according to the New York Heart Association (NYHA) score (including Grade II) ; Clear diagnosis of cirrhosis;
Active infections other than EBV that have not yet been controlled;
Positive for hepatitis B virus or hepatitis C virus;
Active massive hemorrhage of internal organs (including gastrointestinal hemorrhage, alveolar hemorrhage, intracranial hemorrhage, etc.);
Trial design
Treatments tested in this trial
- NCR300(Allogenic Ipsc-derived Natural Killer cells )