A Study on Efficacy and Safety of iNK Cells for CAEBV /EBV-HLH After Allo-HSCT

Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
AgeUp to 65
SponsorBeijing Friendship Hospital

About this trial

To evaluate the efficacy and safety of iNK cells infusion in patients with chronic active Epstein-Barr virus infection (CAEBV) and EBV-associated hemophagocytic lymphohistiocytosis (EBV-HLH) after allogeneic hematopoietic stem cell transplantation (allo-HSCT)

Eligibility criteria

Qualifiers

≤65 years,ECOG :0-2;

Cardiac EF≥40%, creatinine clearance ≥50%; aminotransferase(ALT/AST)<200U/L。;

In patients with HLH, HLH efficacy ≥Partial Response after prior treatment is required;

Estimated survival time is longer than three months;

Disqualifiers

Patients with evidence of grade II or more serious heart disease according to the New York Heart Association (NYHA) score (including Grade II) ; Clear diagnosis of cirrhosis;

Active infections other than EBV that have not yet been controlled;

Positive for hepatitis B virus or hepatitis C virus;

Active massive hemorrhage of internal organs (including gastrointestinal hemorrhage, alveolar hemorrhage, intracranial hemorrhage, etc.);

Trial design

Treatments tested in this trial

  • NCR300(Allogenic Ipsc-derived Natural Killer cells )

Treatment groups

15 Participants
are divided into 1 treatment group

Sponsors and collaborators