Radiation pneumonitis is the main dose-limiting toxicity of thoracic radiotherapy, which can affect life quality, survival, and the tumor-controlling effects of patients receiving thoracic radiotherapy.
The purpose of this study is to:
* Identify biomarkers including serum proteins, gene expression, genetic changes, and epigenetic modifications that determine radiation pneumonitis. * Investigate the relationship between radiation pneumonitis and other toxicities induced by radiotherapy. * Construct a predictive model for radiation pneumonitis. * Evaluate survival and treatment outcome of patients with radiation pneumonitis.
Clinical diagnosis of lung cancer by histology
Radiation dose at least 45 Gy
Karnofsky >60
Age>18
Previous thoracic irradiation
Severe cardiopulmonary diseases
Huazhong University of Science and Technology
Lead sponsor
Hubei Cancer Hospital
Collaborator
Jingjiang People' Hospital
Collaborator