Breast radiation treatment is burdened by acute and chronic toxicities, in most cases mild. However, considering the excellent life expectancy of patients with breast cancer, maintaining a low toxicity profile is of primary importance in order to guarantee a satisfactory quality of life. The definition of the molecular and genetic variables related to radiotoxicity and their integration into predictive molecular signatures may allow the risk of toxicity to be individualized. This would provide the clinician with a useful tool in order to personalize the radiation treatment, thus being able to choose the best technique or schedule for each patient.
Age ≥18 years;
Ability to express appropriate informed consent to treatment;
Distant nonmetastatic breast cancer;
Histology: infiltrating NST(no special type)/lobular carcinoma or ductal carcinoma in situ;
Refusal of radiotherapy treatment (i.e., absence of signed informed consent);
Previous radiation therapy at the same site;
Concomitant chemotherapy with anthracyclines or taxanes;
Inability to maintain treatment position;