The goal of this observational study is to learn if spleen stiffness and other non-invasive markers can help predict recompensation in people with decompensated cirrhosis who are receiving effective treatment for the cause of their liver disease. The main questions it aims to answer are:
* Can spleen stiffness and blood test results predict who will get better and stay better after cirrhosis becomes worse? * What are the features of people who recover after decompensation?
Participants will:
* Be people with decompensated cirrhosis who are already getting effective treatment (such as antiviral therapy or alcohol abstinence) * Be followed over time to check if they remain stable or have more liver problems * Have non-invasive tests done, including spleen stiffness measurement and blood tests
Researchers will track how many participants recover and stay recovered over time, and use that information to build a tool to help predict outcomes in others with cirrhosis.
Male or female, aged 18 to 75 years (inclusive)
Clinically diagnosed decompensated cirrhosis
First decompensated event occurred within 12 months of screening, or no decompensated events in the past 12 months despite a history of decompensation
For HBV: Sustained antiviral suppression
Missing data on first decompensated event
Prior orthotopic liver transplantation or TIPS
Prior splenectomy, splenic embolization, or other shunt surgery
History or current diagnosis of hepatocellular carcinoma