A1-Free vs. Conventional Milk Metabolic Response Study

Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-65
SponsorPurdue University

About this trial

This study will examine how different types of milk affect blood sugar and insulin responses after eating. Specifically, the study compares milk that contains only A2 beta-casein protein (A1-free milk) to conventional milk, which contains both A1 and A2 proteins.

Participants will complete four study visits in which they will consume different milk-based beverages. These include lactose-containing milk and lactose-free milk followed by a lactose drink given later. Blood samples will be collected over several hours to measure glucose and insulin responses. Breath tests and questionnaires will also be used to assess digestion and gastrointestinal symptoms.

The goal of this study is to determine whether milk protein type influences metabolic responses and whether consuming lactose-free milk affects how the body processes lactose when it is consumed later.

Eligibility criteria

Qualifiers

Ability/desire to provide informed consent

Are between 18 and 65 years of age

Are generally healthy, with no known metabolic or gastrointestinal conditions that would affect digestion or metabolism

Are willing to consume milk-based beverages and lactose-containing drinks as part of the study

Disqualifiers

You have a known allergy to milk or dairy products

You are currently pregnant, planning to become pregnant, or breastfeeding

You currently smoke or have used tobacco or nicotine-containing products within the past 3 months

You have a history of excessive alcohol use within the past 30 days

Trial design

Treatments tested in this trial

  • Lactose-Containing A1-Free Milk
  • Lactose-Containing Conventional Milk
  • Lactose-Free A1-Free Milk With Delayed Lactose Drink
  • Lactose-Free Conventional Milk With Delayed Lactose Drink

Treatment groups

35 Participants
are divided into 4 treatment groups

Locations

This trial has no locations

Sponsors and collaborators