Aberrant Synaptic Plasticity in Cocaine Use Disorder: A 11C-UCB-J PET Study
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age21-60
SponsorYale University
About this trial
The purpose of this research study is to measure synaptic density in the brain comparing individuals with cocaine use disorder to healthy controls.
Eligibility criteria
Qualifiers
Age 21-60 years
Physically healthy by medical history, physical, neurological, ECG and laboratory examinations
For females, a negative serum pregnancy test
For CUD: DSM-5 criteria for Cocaine Use Disorder and positive urine toxicology showing recent use
Disqualifiers
DSM-5 criteria for other substance use disorders (e.g., alcohol, opiates, sedative hypnotics), except for nicotine
A primary DSM-5 Axis I major psychiatric disorder (e.g., schizophrenia, bipolar disorder, major depression, etc.) as determined by the Structured Clinical Interview for DSM-5 (SCID-5)
A history of significant and/or uncontrolled medical or neurological illness
Current use of psychotropic and/or potentially psychoactive prescription medications
Trial design
Treatments tested in this trial
- 11C-UCB-J
Treatment groups
80 Participants
are divided into 2 treatment groupsSponsors and collaborators
Yale University
Lead sponsor
National Institute on Drug Abuse (NIDA)
Collaborator
Source ClinicalTrials.gov