The aim of this study is to investigate the clinical efficacy and safety of ablative carbon ion radiotherapy for locally advanced unresectable pancreatic cancer with pencil beam scanning and simultaneous integrated boost (SIB) technology.
Have the ability to sign the written informed consent;
Ductal adenocarcinoma of the pancreas confirmed by histopathology or cytopathology;
Distant metastasis was excluded by imaging assessment (PET-CT, cranial MRI), and was defined as locally advanced unresectable according to NCCN Guidelines Version 2022.1, that is, T4N0-2M0, Stage III (AJCC/UICC Version 8);
The maximum diameter of pancreatic primary lesion and positive lymph node ≤7cm;
Multiple primary pancreatic lesions (>1);
Tumor invaded the adjacent digestive tract;
Radiation therapy history;
Other local treatments history for pancreatic cancer, such as HIFU and irreversible electroporation;