Abnormal Connectivity Involving the Social Reciprocity Network in Autism and the Impact of Neurostimulation in Mitigating the Abnormalities

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age13-18
SponsorChristiana Care Health Services

About this trial

There is no consensus regarding the neurological substrate underpinning ASD. The investigators describe the novel concept of "social reciprocity network" and hypothesize that aberrant connectivity/oscillatory patterns affecting this network contribute to the core deficits in ASD.

The overarching goal of this trial is to explore abnormalities involving the neuronal connectivity and oscillatory patterns within the social reciprocity network and to elucidate the role of modulating this network via rTMS in improving the above measures and social cognition in ASD. Quantitative electroencephalography (QEEG) coherence and spectral power analysis are reliable measures of neuronal connectivity and dynamics. The investigators aim to study the QEEG coherence/spectral power analysis to explore the neuronal dynamics affecting the social reciprocity network in ASD.

Eligibility criteria

Qualifiers

None

Disqualifiers

Patients with ASD exhibiting significant anxiety or contact avoidance, precluding them from cooperating with the procedure

Patients with a known diagnosis of seizures

Presence of any metallic implants or devices in the head or neck area

Pregnant women

Trial design

Treatments tested in this trial

  • transcranial magnetic stimulation

Treatment groups

12 Participants
are divided into 2 treatment groups