Abutment Hydrophilicity on Soft Tissue Morphogenesis

Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorPaolo Pesce

About this trial

The goal of this clinical trial is to evaluate the effect of abutment surface bioactivation via argon plasma treatment on peri-implant soft tissue healing and integration in adult patients undergoing implant therapy.

The main questions it aims to answer are:

Does argon plasma treatment of healing abutments improve the quality and organization of peri-implant connective tissue compared to untreated abutments?

Does the treatment influence histological parameters such as epithelial regeneration, vascularization, inflammatory infiltrate, and keratin layer thickness?

Researchers will compare plasma-treated healing abutments to untreated machined-surface abutments to determine whether the bioactivated surface improves soft tissue morphogenesis.

Participants will:

Undergo implant placement with immediate connection of either a treated or untreated healing abutment.

Have plaque and bleeding indices recorded at 3 months.

Undergo a soft tissue biopsy at 3 months for histological analysis (including evaluation of inflammation, connective tissue, epithelial morphology, vascularization, and keratinization).

Eligibility criteria

Qualifiers

presence of at least 4 mm of keratinized mucosa around the implants

patients aged 18 years or older

medically healthy patients (ASA I), or patients with mild systemic disease (ASA II)

partially edentulous state

Disqualifiers

ASA physical status 3

severe smokers (> 10 cig/day)

patients undergoing bisphosphonate therapy

pregnant or lactating women

Trial design

Treatments tested in this trial

  • the test group were placed in an Argon plasma reactor

Treatment groups

40 Participants
are divided into 2 treatment groups

Locations

This trial has no locations

Sponsors and collaborators

Paolo Pesce

Lead sponsor

Universita degli Studi di Genova

Sponsor institution