Acute Beetroot Juice Supplementation in Pre-eclampsia Pregnancies

Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexFemale
Age18-40
SponsorUniversity of Sao Paulo

About this trial

Pre-eclampsia is a serious condition that typically affects pregnant women after the 20th week of pregnancy, characterized by high blood pressure and damage to organs such as the kidneys and liver. Currently, treatment options are limited, which has prompted researchers to explore alternative approaches. One such promising alternative is dietary nitrate found in vegetables like beetroot, as nitrate can be converted into nitric oxide in the body, which helps lower blood pressure. This study aims to determine the acute effects of nitrate-rich beetroot juice on blood pressure, several blood and salivary markers in pregnant women with pre-eclampsia and healthy pregnant. Furthermore, the study will assess fetal blood flow using Doppler ultrasound. We want to understand the kinetics of nitrate and nitric oxide metabolites and assess the temporal dependency of the hypotensive response. Through this investigation, we seek evidence of nitrate-enriched beetroot juice as an adjunct therapy in managing pre-eclampsia.

Eligibility criteria

Qualifiers

Pre-eclampsia pregnat women

Pregnant women at or beyond the 20th week of gestation.

Hospitalized at Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto.

Diagnosed with early-onset pre-eclampsia confirmed by a medical professional.

Disqualifiers

Multiple pregnancies.

Uncontrolled arterial hypertension (Systolic Blood Pressure > 160 mmHg or Diastolic Blood Pressure > 100 mmHg).

Pregnant women with a body mass index > 40 kg/m²

Severe gestational complications.

Trial design

Treatments tested in this trial

  • Beetroot juice
  • Placebo juice

Treatment groups

60 Participants
are divided into 4 treatment groups

Sponsors and collaborators

University of Sao Paulo

Lead sponsor

Hospital das Clínicas de Ribeirão Preto

Collaborator

Universidade Estadual Paulista Júlio de Mesquita Filho

Collaborator