About this trial
The goal of this observational study is to learn about the brain imaging changes associated with concussion using a very detailed (7T) MRI scanner.
To do this, the investigators will study 7T MRI brain imaging in patients aged 18-40 who present to the Emergency Department within 96 hours of a head injury. Patients will be eligible if they have had a normal CT brain as part of their usual care.
The investigators will compare brain imaging from patients who have completely recovered from an episode of concussion to patients who still have significant symptoms at approximately 28 days after a head injury.
The study attempts to answer the following questions:
1. Do patients with ongoing symptoms after concussion show greater 7T MRI brain imaging evidence of changes to the blood vessels at approximately 28 days after their injury in comparison to patients who have recovered fully? 2. Do patients with ongoing symptoms after concussion show greater 7T MRI brain imaging evidence of changes in brain signaling pathways at approximately 28 days after their injury, in comparison to patients who have recovered fully?
Eligibility criteria
Qualifiers
Isolated head trauma
Initial review within 96h of injury
No acute findings on CT head
Aged 18-40 years
Disqualifiers
Patient unable to give informed consent
Patient unable to speak and understand English
Patients where alternative diagnosis cannot be excluded
Polytrauma
Trial design
Treatments tested in this trial
- 7T MRI brain