This interventional, randomized, sham-controlled study will examine whether Acute Intermittent Hypoxia (AIH) delivered immediately before Myoelectric Interface Neurorehabilitation Training (MINT)-based locomotor training improves gait in people with Multiple Sclerosis. The primary objectives are to evaluate changes in gait speed and endurance, with secondary objectives assessing spatiotemporal gait parameters, fatigue, and safety. Participants will receive AIH or sham priming followed by standardized treadmill and/or overground gait training, with outcome measures collected before and after the intervention across multiple sessions.
Diagnosis of clinically definite multiple sclerosis
Patient-Determined Disease Steps (PDDS) score between 3 and 6
Relapse-free for at least 6 months prior to enrollment
Age ≥ 18 years and ≤ 75 years
Uncontrolled hypertension or hypotension outside the required ranges
History of epilepsy or seizures
Uncontrolled pulmonary, cardiovascular, or orthopedic disease
Premorbid or ongoing major psychiatric illness (e.g., major depression, psychosis)