Affect-based Impulsivity in Borderline Personality Disorder
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-45
SponsorUniversity of North Carolina, Chapel Hill
About this trial
The purpose of this research study is to investigate how personality traits and neuroendocrine systems relate to decision-making patterns in individuals 18-45 years old. The main question it aims to answer is how neuroendocrine activity impacts decision-making.
Participants will complete online behavioral tasks, a stress induction procedure, self-report surveys, and a cognitive assessment. During the session, psychophysiological measures will be collected, including electrocardiogram (ECG) and cardiac impedance (ICG) to monitor heart rate and blood flow, as well as electrodermal activity (EDA), blood drop samples, and saliva collection to assess nervous system activity.
Eligibility criteria
Qualifiers
Score of 38 or higher on Personality Assessment Inventory-Borderline Scale (PAI-BOR)
Participants in the BPD group will be primarily recruited from the two
3+ BPD symptoms, one of which must be affective instability, per clinical interview
Participants must score at least 80 on the Reynolds Intellectual Screening Test (RIST).
Disqualifiers
Use of as needed antihypertensive agents within 12 hours prior to lab visit
Inability to refrain from using as needed psychotropic medications for 12 hours prior to lab visit
History of psychotic disorder, Bipolar I disorder, autism spectrum disorder, reactive attachment disorder, pervasive developmental disorder, motor disorder, head injury, mental retardation, neurological disorder, or current substance dependence
Family history of Bipolar I disorder in a first degree relative.
Trial design
Treatments tested in this trial
- Stress Induction
Treatment groups
106 Participants
are divided into 1 treatment groupSponsors and collaborators
University of North Carolina, Chapel Hill
Lead sponsor
North Carolina Translational and Clinical Sciences Institute
Collaborator
Source ClinicalTrials.gov